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Rapidly-dissolved loratadine tablets and preparation process thereof

A technology for loratadine and tablets, which is applied in the field of tablets containing loratadine and its preparation process, can solve the problems of difficult production, complex preparation process, and inability to improve bioavailability, and achieve easy operation, Simple preparation process and rapid dissolution effect

Active Publication Date: 2015-04-22
JIANGSU LIANHUAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is well known that for poorly soluble drugs, dissolution rate is a key factor affecting bioavailability, and simply improving disintegration cannot improve bioavailability
CN 102451169 A relates to loratadine freeze-dried tablets and the prescription and process for preparing loratadine freeze-dried tablets by freeze-drying method, which has problems such as complicated preparation process and difficulty in large-scale industrial production

Method used

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  • Rapidly-dissolved loratadine tablets and preparation process thereof
  • Rapidly-dissolved loratadine tablets and preparation process thereof
  • Rapidly-dissolved loratadine tablets and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) Blank die

[0027] Microcrystalline Cellulose PH102 90g

[0028] Crospovidone 5g

[0029] Magnesium Stearate 1g

[0030] (2) Drug-containing coating layer

[0031]

[0032] Preparation Process:

[0033] ①Weigh the microcrystalline cellulose, crospovidone, and magnesium stearate of the prescribed amount, mix them evenly, and punch them into Φ6.5mm tablets to obtain blank cores;

[0034] ②Dissolve loratadine and copovidone in ethanol, and dissolve polyethylene glycol in water at the same time, and then mix the two solutions to obtain a drug-containing coating solution;

[0035] ③Put the blank tablet core prepared in step ① into the coating pan of the high-efficiency coating machine, preheat the tablet bed to about 40°C, spray the drug-containing coating liquid prepared in step ② for coating, and dry for 30 minutes after coating is completed Left and right, that is.

Embodiment 2

[0037] (1) Blank die

[0038]

[0039] (2) Drug-containing coating layer

[0040]

[0041] Preparation Process:

[0042] ① Weigh the prescribed amount of lactose, pregelatinized starch, croscarmellose sodium, and zinc stearate, mix them evenly, and punch them into Φ7.0mm tablets to obtain blank cores;

[0043] ②Dissolve loratadine and copovidone in ethanol, and dissolve polyethylene glycol in water at the same time, and then mix the two solutions to obtain a drug-containing coating solution;

[0044] ③Put the blank tablet core prepared in step ① into the coating pan of the high-efficiency coating machine, preheat the tablet bed to about 40°C, spray the drug-containing coating liquid prepared in step ② for coating, and dry for 30 minutes after coating is completed Left and right, that is.

Embodiment 3

[0046] (1) Blank die

[0047]

[0048]

[0049] (2) Drug-containing coating layer

[0050]

[0051] Preparation Process:

[0052] ①Weigh the prescribed amount of sorbitol, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, polacrilin potassium, and magnesium aluminum silicate, mix them evenly, and punch them into Φ8.0mm tablets to obtain blank cores;

[0053] ②Dissolve loratadine and copovidone in ethanol, and dissolve polyethylene glycol in water at the same time, and then mix the two solutions to obtain a drug-containing coating solution;

[0054] ③Put the blank tablet core prepared in step ① into the coating pan of the high-efficiency coating machine, preheat the tablet bed to about 40°C, spray the drug-containing coating liquid prepared in step ② for coating, and dry for 30 minutes after coating is completed Left and right, that is.

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Abstract

The invention discloses rapidly-dissolved loratadine tablets and a preparation process thereof. The tablets comprise blank tablet cores and medicine-containing coating layers, wherein each medicine-containing coating layer consists of loratadine, copovidone and polyethylene glycol; and the rapidly-dissolved loratadine tablets are prepared by coating the blank tablet cores by virtue of an efficient coating machine. The loratadine tablets disclosed by the invention are rapid in dissolution, and ensure that the dissolution rate can reach more than 95% in 5 minutes; and meanwhile, the loratadine tablets have the advantages of simple preparation process and easiness in operation.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a pharmaceutical preparation, in particular to a tablet containing loratadine and a preparation process thereof. Background technique [0002] Loratadine is white or off-white powder, insoluble in water, but easily soluble in ethanol, acetone, and chloroform. The chemical name is 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-enyl)-1-piperidinecarboxy ethyl acetate, molecular formula C 22 h 23 ClN 2 o 2 , the molecular weight is 382.89, and the structural formula is as follows: [0003] [0004] Loratadine belongs to the second generation of histamine H1-receptor antagonist. It is a potent and long-acting tricyclic antihistamine. It has a selective effect on peripheral receptors. It is clinically used for allergic dermatitis and Treatment of urticaria. It has high curative effect, rapid onset, strong effect, no toleran...

Claims

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Application Information

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IPC IPC(8): A61K9/32A61K31/4545A61K47/32A61K47/34A61P17/00A61P37/08
Inventor 严白双
Owner JIANGSU LIANHUAN PHARMA
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