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Dual-mode sensor for detecting Cd<2+> based on magnetic nanoparticles and preparation method of dual-mode sensor

A technology of magnetic nanoparticles and gold nanoparticles, which is applied in the measurement of color/spectral properties and analysis by nuclear magnetic resonance. The effect of high control, high precision and strong anti-interference ability

Inactive Publication Date: 2015-04-22
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the traditional detection technology has poor anti-interference ability and low precision, and cannot quickly detect Cd in samples. 2+

Method used

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  • Dual-mode sensor for detecting Cd&lt;2+&gt; based on magnetic nanoparticles and preparation method of dual-mode sensor
  • Dual-mode sensor for detecting Cd&lt;2+&gt; based on magnetic nanoparticles and preparation method of dual-mode sensor
  • Dual-mode sensor for detecting Cd&lt;2+&gt; based on magnetic nanoparticles and preparation method of dual-mode sensor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] (1), preparation of specific receptor unit

[0040] 15 mL of DMSO (dimethyl sulfoxide) was added to 1.0 g of chloroacetyl catechol and 300 mg of sodium azide. React at room temperature for 8 h, add 50 mL of ice water, and extract three times with ether. The organic phase was washed with Na 2 CO 3 After drying, the organic phase was distilled under reduced pressure to obtain a powder sample. Weigh 380mg powder sample and dissolve in 15mLH 2 In O, mix well; add 50 μL of ethyl propiolate, heat and stir for 12 hours, after the reaction is completed, concentrate and filter, and recrystallize, that is, the specific receptor unit. figure 1 is the NMR spectrum of the prepared specific receptor unit.

[0041] (2) Hybrid Au-Fe 3 o 4 preparation of

[0042] Add 1 mL of oleylamine and 100 mg of chloroauric acid to 10 mL of tetralin, heat up to 70°C, react for 5 hours, cool, add ethanol and centrifuge, disperse in n-hexane to obtain gold nanoparticles.

[0043] Add 1 mL of ...

Embodiment 2

[0051] (1), preparation of specific receptor unit

[0052] 20 mL of DMSO (dimethyl sulfoxide) was added to 1.0 g of chloroacetyl catechol and 1.0 g of sodium azide. React at room temperature for 12 h, add 60 mL of ice water, and extract three times with ether. The organic phase was washed with Na 2 CO 3 After drying, the organic phase was distilled under reduced pressure to obtain a powder sample. Weigh 380mg powder sample and dissolve in 15mLH 2 O, mix well; add 100 μL of ethyl propiolate, stir at room temperature for 12 hours, after the reaction, concentrate and filter, and recrystallize, that is, the specific receptor unit.

[0053] (2) Hybrid Au-Fe 3 o 4 preparation of

[0054] Add 10 mL of oleylamine and 1 g of chloroauric acid to 100 mL of tetralin, heat up to 70° C., react for 5 h, cool, add ethanol for centrifugation, and disperse in n-hexane to obtain gold nanoparticles.

[0055] Add 1 mL of oleic acid in 20 mL of octadecene, then add 2.5 mL of gold nanopartic...

Embodiment 3

[0059] (1) The preparation of the specific receptor unit is the same as in Example 1.

[0060] (2) Hybrid Au-Fe 3 o 4 The preparation is with embodiment 1.

[0061] (3) Detection of Cd based on magnetic nanoparticles 2+ Preparation of the dual-mode sensor

[0062] Take 30mg of specific receptor unit, 40mg of mPEG-SH; 200mg of anhydrous sodium carbonate, dissolve in water, mix well to form an aqueous solution; take 4mL of hybrid Au-Fe 3 o 4 Dilute nanoparticles (10-18mg) to 5mL, add to the above aqueous solution, shake the shaker to react? hours; centrifuge and disperse in water.

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Abstract

The invention belongs to the technical field of rapid detection, and particularly relates to a dual-mode sensor for detecting Cd<2+> based on magnetic nanoparticles and a preparation method of the dual-mode sensor. The method comprises the following steps: firstly, preparing a specific receptor unit, preparing Au-Fe3O4 nanoparticles, and finally dissolving the specific receptor unit, mPEG-SH and anhydrous sodium carbonate into water; and adding the mixture to an Au-Fe3O4 nanoparticle solution, and carrying out shaking table oscillating reaction for 10-20 hours. According to the dual-mode sensor disclosed by the invention, the disperse state of the nanoparticles changes into an aggregation state from a dispersed state in the presence of Cd<2+> ions. The relaxation time of water protons around the nanoparticles is changed by the change of the state; and due to the presence of gold nanoparticles, ultraviolet absorption spectrums of the nanoparticles change, so that the Cd<2+> is detected by two methods, namely an ultraviolet absorption detection method and a nuclear magnetic resonance method; and the dual-mode sensor has the advantages of high accuracy, high anti-jamming capability and high selectivity.

Description

technical field [0001] The invention belongs to the technical field of rapid detection, in particular to a method for detecting Cd based on magnetic nanoparticles. 2+ dual-mode sensor and its preparation method. Background technique [0002] Environmental pollution and food safety directly endanger public health and have serious impacts on social and economic development. In recent years, environmental pollution incidents and food contamination incidents have occurred frequently, which have threatened people's safety. It is imperative to deal with each emergency incident in a timely and secure manner. Emergency monitoring is the premise and basis for dealing with similar incidents. The most critical thing is to monitor the concentration changes of pollutants in the early stage or even the embryonic stage of the event development. Therefore, the development of on-site rapid detection technology is very important. Heavy metal pollution is an important pollutant that needs p...

Claims

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Application Information

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IPC IPC(8): G01N24/08G01N21/33
Inventor 杨仕平张钖周治国沈金超杨艳
Owner SHANGHAI NORMAL UNIVERSITY
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