Complex of helical chain polysaccharide derivative co-loaded single-walled carbon nanotube and nucleic acid as well as preparation method and application of complex
A technology of single-walled carbon nanotubes and polysaccharide derivatives, which is used in pharmaceutical combinations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problem that the water dispersion stability of single-walled carbon nanotubes needs to be improved. , Destruction of the chemical structure of SWCNTs, the dispersion stability needs to be improved, etc., to achieve obvious photothermal conversion effect, improve biocompatibility, and easy to implement.
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Embodiment 1
[0038] (1) Weigh 1g of potato amylose and dissolve it in 50mL of dimethyl sulfoxide, under the protection of nitrogen, add 1g of CDI, stir and react at 30°C for 2h, then add dropwise 10 times the molar amount of CDI to the system ethylenediamine, continue to stir and react for 22h, then transfer to a dialysis bag with a molecular weight cut-off of 14000 for dialysis with water for 2 days, and obtain the amylose derivative (EA-Amy-I) containing the primary amino group after freeze-drying;
[0039] (2) EA-Amy-I was dissolved in water to prepare a solution of 2 mg / mL, adding 0.5 times the single-walled carbon nanotubes (length 1-3 μm, diameter 1-2nm) of EA-Amy-I quality, and then Use 65kHz ultrasonic waves in the ice-water bath for treatment, and the specific cycle is 30 minutes every 5 minutes, and a total of 3 cycles of treatment are performed. The obtained mixed system is centrifuged at 1000 rpm for 3 minutes, and the obtained dispersion is filtered with a 220 nm microporous memb...
Embodiment 2
[0050] (1) Weigh 1g of potato amylose and dissolve it in 50mL of dimethyl sulfoxide. Under the protection of nitrogen, add 3g of CDI, stir and react at 30°C for 2h, and then dropwise add 10 times the molar amount of CDI to the system ethylenediamine, continue to stir and react for 22h, and transfer to a dialysis bag with a molecular weight cut-off of 14000 for dialysis with water for 2 days, and obtain an amylose derivative (EA-Amy-II) containing primary amino groups after freeze-drying;
[0051] (2) EA-Amy-II was dissolved in water to prepare a solution of 2mg / mL, adding 0.5 times the quality of EA-Amy-II single-walled carbon nanotubes (length 1-3μm, diameter 1-2nm), and then Use 65kHz ultrasonic waves in the ice-water bath for treatment, and the specific cycle is 30 minutes every 5 minutes, and a total of 3 cycles of treatment are performed. The obtained mixed system is centrifuged at 1000 rpm for 3 minutes, and the obtained dispersion is filtered with a 220 nm microporous me...
Embodiment 3
[0062] (1) Weigh 1g of corn amylose and dissolve it in 40mL of dimethyl sulfoxide. Under the protection of nitrogen, add 0.1g of CDI, stir and react at 25°C for 1h, and then dropwise add 2 times the molar amount of CDI to the system. amount of ethylenediamine, after continuing to stir and react for 23h, transfer it to a dialysis bag with a molecular weight cut-off of 1000 for dialysis with water for 7 days, and obtain amylose derivatives containing primary amino groups after freeze-drying;
[0063] (2) the amylose derivative of step (1) is dissolved in water and is formulated into a solution of 5 mg / mL, and single-walled carbon nanotubes (length 0.5-2 μm, diameter 3- 5nm), and then use 40kHz ultrasonic waves in an ice-water bath to process, the specific cycle is ultrasonic 20min every 1min, a total of 4 cycles of processing, the resulting mixed system is centrifuged at 3000rpm for 1min, and the resulting dispersion is separated by a 220nm micro filter through a pore filter, re...
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