Esomeprazole enteric coated pellet preparation and preparation method thereof
A technology for esomeprazole magnesium enteric-coated pellets and preparations, which can be applied to pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve the problem of wasting manpower, material resources, and coating time. It can prevent the problems of long and drug loading efficiency, and achieve the effect of preventing mutual sticking, reducing weight and volume, and improving coating efficiency.
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[0048] Example 1: Preparation of esomeprazole magnesium enteric pellets.
[0049] Esomeprazole magnesium enteric-coated pellets were prepared according to the following formula.
[0050]
[0051] The specific preparation process of the enteric-coated pellets is as follows.
[0052] 1. Drug-loaded layer coating:
[0053] A. Add povidone K30 (Beijing Fengli Jingqiu Commerce Co., Ltd.) into absolute ethanol (Sinopharm Chemical Reagent Co., Ltd.), stir slowly to make it fully dissolved, and then add esomeprazole magnesium three Hydrate (Jinan Hongfangde Pharmaceutical Technology Co., Ltd.), stir evenly to obtain a clear drug-loading layer coating solution, ready for use;
[0054] B. Turn on the fluidized bed coating machine (Shenzhen Xinyite Technology Co., Ltd.), and put the sucrose into the fluidized bed coating machine to coat the drug-loaded layer (coating parameters: material temperature is 30°C, enter The air temperature is 45°C, the atomization pressure is 0.08MPa, and the spray sp...
Example Embodiment
[0061] Example 2: Preparation of esomeprazole magnesium enteric pellets.
[0062] Esomeprazole magnesium enteric-coated pellets were prepared according to the following formula.
[0063]
[0064] The specific preparation process of the enteric-coated pellets is as follows.
[0065] 1. Drug-loaded layer coating:
[0066] A. Add povidone K30 (Beijing Fengli Jingqiu Commerce Co., Ltd.) into absolute ethanol (Sinopharm Chemical Reagent Co., Ltd.), stir slowly to make it fully dissolved, and then add magnesium oxide (Beijing Fengli Jing Qiu Trading Co., Ltd.) was slowly added to the povidone K30 solution, continuously stirred to form a suspension, and then esomeprazole magnesium trihydrate (Jinan Hongfangde Pharmaceutical Technology Co., Ltd.) was added, stirred evenly, and clarified The coating liquid for the drug-loaded layer is reserved;
[0067] B. Turn on the fluidized bed coating machine (Shenzhen Xinyite Technology Co., Ltd.), and put the sucrose into the fluidized bed coating machi...
Example Embodiment
[0074] Example 3: Preparation of esomeprazole magnesium enteric-coated pellets.
[0075] Esomeprazole magnesium enteric-coated pellets were prepared according to the following formula.
[0076]
[0077] The specific preparation process of the enteric-coated pellets is as follows.
[0078] 1. Drug-loaded layer coating:
[0079] A. Add povidone K30 (Beijing Fengli Jingqiu Commerce Co., Ltd.) into absolute ethanol (Sinopharm Chemical Reagent Co., Ltd.), stir slowly to make it fully dissolved, and then add esomeprazole magnesium three Hydrate (Jinan Hongfangde Pharmaceutical Technology Co., Ltd.), stir evenly to obtain a clear drug-loading layer coating solution, ready for use;
[0080] B. Turn on the fluidized bed coating machine (Shenzhen Xinyite Technology Co., Ltd.), and put the sucrose into the fluidized bed coating machine to coat the drug-loaded layer (coating parameters: material temperature is 30°C, enter The air temperature is 45°C, the atomization pressure is 0.08MPa, and the s...
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