Absorbable starch hemostatic powder and its preparation method and application

Abstract

The invention relates to an absorbable starch bleeding-stopping powder and preparation method thereof. The method comprises: taking plant native starch and carboxy methyl starch as raw materials, performing emulsion dispersing under the effects of span 80, tween 80 and plant oil at pH of 9-10 at a temperature of 45-70 DEG C, crosslinking with sodium trimetaphosphate, extracting with ethyl acetate and performing liquid separation, washing with anhydrous ethanol, drying in a baking oven, and sterilizing, so as to obtain the absorbable starch bleeding-stopping powder. The bleeding-stopping powder has good biocompatibility, is directly applicable to general bleeding, deep bleeding and bleeding at positions where operations are difficult to reach, and is simple and convenient to use. The bleeding-stopping power employs starch as the raw material, is nontoxic, free of stimulation, wide in source, low in cost and simple and feasible in technology, and has wide clinic application prospect.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to an absorbable starch hemostatic powder and a preparation method and application thereof. Background technique [0002] War wounds, trauma first aid and surgical operations will all cause bleeding. This problem needs to be solved urgently. The normal human body has the function of hemostasis. Slow and small amount of bleeding can stop bleeding by relying on its own function. The body cannot stop the bleeding by itself, nor can it only rely on ordinary hemostatic bandages to stop the bleeding. If the patient loses too much blood, it may cause shock and even endanger life and health. Currently, the commonly used effective hemostasis method is to use biocompatible absorbable materials to stop bleeding. It is particularly important to provide a safe, effective, easy-to-use, and low-cost hemostatic material in hemostasis such as surgery and first aid. [0003] At presen...

AI Technical Summary

Problems solved by technology

[0003] At present, the clinically used hemostatic materials mainly include fibrin glue, collagen, gelatin sponge and cellulose hemostatic materials. These materials have achieved good results in animal experiments and clinical applications, but there are also some shortcomings: The raw material is derived from animal tissue, which is a foreign protein, which is prone to rejection and has potential sensitization; gelatin absorbs slowly, generally more than 4 weeks, which will increase the risk of wound infection; cellulose, the human body lacks enzymes to degrade it , the degradation time is long, which may bring side effects such as infection to the patient

At present, the representative starch hemostatic material is Arista hemostatic powder produced in the United States. Although its hemostatic effect is good, it is cross-linked with epichlorohydrin, which is potentially toxic and expensive, which limits its application.

[0005] The absorbable hemostatic powder prepared by the present invention has a high-efficiency hemostatic effect, and there is no domestic report on the patent of the hemostatic material prepared from plant raw starch and carboxymethyl starch