Magnetic nanohydrogel and preparation method thereof

A nano-hydrogel, magnetic nano-technology is applied in the field of nano-hydrogel to achieve the effects of improving magnetic signal, simple process and improving clarity

Inactive Publication Date: 2015-05-13
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, there is no report on the use of...

Method used

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  • Magnetic nanohydrogel and preparation method thereof
  • Magnetic nanohydrogel and preparation method thereof
  • Magnetic nanohydrogel and preparation method thereof

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Embodiment 1

[0031] (1) Dissolve 0.9710g N,N-diethylacrylamide DEA, 0.0292g acrylic acid AA, 0.0603g N,N'-methylenebisacrylamide and 0.0502g sodium lauryl sulfate in 95g deionized water , and bubbling N at room temperature 2 Deoxygenation, magnetic stirring for 120 minutes;

[0032] (2) The reaction temperature rises to 70°C, under N 2 Insulate the above solution under protection for 30 minutes;

[0033] (3) then prepare the ammonium persulfate solution that mass concentration is 0.4%, get 4.9987g and add in the above-mentioned solution, keep N 2 atmosphere, continue to react for 4 hours;

[0034](4) Then soak the obtained reactant in deionized water for dialysis for 4 days, change the water twice a day, remove the residual reaction raw materials and the electrolyte in the reaction system, the molecular weight cut-off of the dialysis bag used is 8000~14000, and the AA content is 5mol%. Copolymerized hydrogels were sampled for DLS testing.

Embodiment 2

[0036] (1) Dissolve 0.9409g DEA, 0.0587g AA, 0.0605g N,N'-methylene bisacrylamide and 0.0497g sodium lauryl sulfate in 95g deionized water, and blow N at room temperature 2 Deoxygenation, magnetic stirring for 120 minutes;

[0037] (2) The reaction temperature rises to 70°C, under N 2 Insulate the above solution under protection for 30 minutes;

[0038] (3) then prepare the ammonium persulfate solution that mass concentration is 0.4%, get 5.0004g and add in the above-mentioned solution, keep N 2 atmosphere, continue to react for 4 hours;

[0039] (4) Then soak the obtained reactant in deionized water for dialysis for 4 days, change the water twice a day, remove the residual reaction raw materials and the electrolyte in the reaction system, the molecular weight cut-off of the dialysis bag used is 8000~14000, and the AA content is 10mol%. Copolymerized hydrogels were sampled for DLS testing.

Embodiment 3

[0041] (1) Dissolve 0.1243g DEA, 0.8758g AA, 0.0601g N,N'-methylene bisacrylamide and 0.0502g sodium lauryl sulfate in 95g deionized water, and blow N at room temperature 2 Deoxygenation, magnetic stirring for 120 minutes;

[0042] (2) The reaction temperature rises to 70°C, under N 2 Insulate the above solution under protection for 30 minutes;

[0043] (3) then preparation mass concentration is the ammonium persulfate solution of 0.4%, gets 5.0006g and adds in the above-mentioned solution, keeps N 2 atmosphere, continue to react for 4 hours;

[0044] (4) Soak the obtained reactant in deionized water and dialyze for 4 days, change the water twice a day, remove the residual reaction raw materials and the electrolyte in the reaction system, the molecular weight cut-off of the dialysis bag used is 8000~14000, and the AA content is 20mol% Copolymerized hydrogels were sampled for DLS testing.

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Abstract

The invention relates to magnetic nanohydrogel and a preparation method thereof. The magnetic nanohydrogel is prepared by coating Fe3O4 particles with poly(N,N-diethylacrylamide-co-acrylic acid) P(DEA-co-AA). The preparation method comprises the following steps: (1) dissolving a monomer A, a monomer B, a cross-linking agent and an emulsifier in de-ionized water, stirring at 20-25 DEG C in a nitrogen atmosphere, heating to 65-80 DEG C, keeping the temperature, adding an initiator, continuously reacting for 0.5-8 hours, and dialyzing to obtain copolymerized nanohydrogel; (2) adjusting the pH (potential of hydrogen) value of the copolymerized nanohydrogel, adding FeSO4.7H2O, stirring for 8-24 hours, dialyzing, adding NaNO2 and NH3.H2O, and performing centrifugal dialysis treatment to obtain the magnetic nanohydrogel. Compared with a conventional Fe3O4 particle-coated compound, the magnetic nanohydrogel is relatively good in size controllability and monodispersity and relatively excellent in magnetic property; the preparation method is simple in process, green and environment-friendly.

Description

technical field [0001] The invention belongs to the field of nano hydrogels, in particular to a magnetic nano hydrogel and a preparation method thereof. Background technique [0002] Magnetic hydrogels have the dual advantages of inorganic magnetic particles and hydrogel polymers, so they are widely used in microwave absorption, electromagnetic shielding, electrochemical displays, molecular devices, nonlinear optical materials, biomedicine, environmental protection, bioengineering, material science, etc. widely used. In particular, magnetic particles have been studied in magnetic resonance imaging, drug delivery, magnetic hyperthermia, etc. in biomedicine, but the particle size of magnetic particles is too small, easy to aggregate, and Fe 3 o 4 The particle surface is hydrophobic, so it can be coated with hydrophilic substances for application in the body. The most typical one is poly N-isopropylacrylamide (PNIPA) hydrogel, whose volume phase transition temperature (VPTT)...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L33/24C08L33/02C08K3/22C08F220/54C08F220/06C08F222/38C08F2/26C01G49/08
Inventor 鲁希华马天泽李雪婷安冬石小迪
Owner DONGHUA UNIV
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