Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Magnetic nanohydrogel and preparation method thereof

A nano-hydrogel, magnetic nano-technology is applied in the field of nano-hydrogel to achieve the effects of improving magnetic signal, simple process and improving clarity

Inactive Publication Date: 2015-05-13
DONGHUA UNIV
View PDF2 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report on the use of P(DEA-co-AA) as the coating material of magnetic hydrogel

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Magnetic nanohydrogel and preparation method thereof
  • Magnetic nanohydrogel and preparation method thereof
  • Magnetic nanohydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Dissolve 0.9710g N,N-diethylacrylamide DEA, 0.0292g acrylic acid AA, 0.0603g N,N'-methylenebisacrylamide and 0.0502g sodium lauryl sulfate in 95g deionized water , and bubbling N at room temperature 2 Deoxygenation, magnetic stirring for 120 minutes;

[0032] (2) The reaction temperature rises to 70°C, under N 2 Insulate the above solution under protection for 30 minutes;

[0033] (3) then prepare the ammonium persulfate solution that mass concentration is 0.4%, get 4.9987g and add in the above-mentioned solution, keep N 2 atmosphere, continue to react for 4 hours;

[0034](4) Then soak the obtained reactant in deionized water for dialysis for 4 days, change the water twice a day, remove the residual reaction raw materials and the electrolyte in the reaction system, the molecular weight cut-off of the dialysis bag used is 8000~14000, and the AA content is 5mol%. Copolymerized hydrogels were sampled for DLS testing.

Embodiment 2

[0036] (1) Dissolve 0.9409g DEA, 0.0587g AA, 0.0605g N,N'-methylene bisacrylamide and 0.0497g sodium lauryl sulfate in 95g deionized water, and blow N at room temperature 2 Deoxygenation, magnetic stirring for 120 minutes;

[0037] (2) The reaction temperature rises to 70°C, under N 2 Insulate the above solution under protection for 30 minutes;

[0038] (3) then prepare the ammonium persulfate solution that mass concentration is 0.4%, get 5.0004g and add in the above-mentioned solution, keep N 2 atmosphere, continue to react for 4 hours;

[0039] (4) Then soak the obtained reactant in deionized water for dialysis for 4 days, change the water twice a day, remove the residual reaction raw materials and the electrolyte in the reaction system, the molecular weight cut-off of the dialysis bag used is 8000~14000, and the AA content is 10mol%. Copolymerized hydrogels were sampled for DLS testing.

Embodiment 3

[0041] (1) Dissolve 0.1243g DEA, 0.8758g AA, 0.0601g N,N'-methylene bisacrylamide and 0.0502g sodium lauryl sulfate in 95g deionized water, and blow N at room temperature 2 Deoxygenation, magnetic stirring for 120 minutes;

[0042] (2) The reaction temperature rises to 70°C, under N 2 Insulate the above solution under protection for 30 minutes;

[0043] (3) then preparation mass concentration is the ammonium persulfate solution of 0.4%, gets 5.0006g and adds in the above-mentioned solution, keeps N 2 atmosphere, continue to react for 4 hours;

[0044] (4) Soak the obtained reactant in deionized water and dialyze for 4 days, change the water twice a day, remove the residual reaction raw materials and the electrolyte in the reaction system, the molecular weight cut-off of the dialysis bag used is 8000~14000, and the AA content is 20mol% Copolymerized hydrogels were sampled for DLS testing.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to magnetic nanohydrogel and a preparation method thereof. The magnetic nanohydrogel is prepared by coating Fe3O4 particles with poly(N,N-diethylacrylamide-co-acrylic acid) P(DEA-co-AA). The preparation method comprises the following steps: (1) dissolving a monomer A, a monomer B, a cross-linking agent and an emulsifier in de-ionized water, stirring at 20-25 DEG C in a nitrogen atmosphere, heating to 65-80 DEG C, keeping the temperature, adding an initiator, continuously reacting for 0.5-8 hours, and dialyzing to obtain copolymerized nanohydrogel; (2) adjusting the pH (potential of hydrogen) value of the copolymerized nanohydrogel, adding FeSO4.7H2O, stirring for 8-24 hours, dialyzing, adding NaNO2 and NH3.H2O, and performing centrifugal dialysis treatment to obtain the magnetic nanohydrogel. Compared with a conventional Fe3O4 particle-coated compound, the magnetic nanohydrogel is relatively good in size controllability and monodispersity and relatively excellent in magnetic property; the preparation method is simple in process, green and environment-friendly.

Description

technical field [0001] The invention belongs to the field of nano hydrogels, in particular to a magnetic nano hydrogel and a preparation method thereof. Background technique [0002] Magnetic hydrogels have the dual advantages of inorganic magnetic particles and hydrogel polymers, so they are widely used in microwave absorption, electromagnetic shielding, electrochemical displays, molecular devices, nonlinear optical materials, biomedicine, environmental protection, bioengineering, material science, etc. widely used. In particular, magnetic particles have been studied in magnetic resonance imaging, drug delivery, magnetic hyperthermia, etc. in biomedicine, but the particle size of magnetic particles is too small, easy to aggregate, and Fe 3 o 4 The particle surface is hydrophobic, so it can be coated with hydrophilic substances for application in the body. The most typical one is poly N-isopropylacrylamide (PNIPA) hydrogel, whose volume phase transition temperature (VPTT)...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C08J3/075C08L33/24C08L33/02C08K3/22C08F220/54C08F220/06C08F222/38C08F2/26C01G49/08
Inventor 鲁希华马天泽李雪婷安冬石小迪
Owner DONGHUA UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com