Novel strain Clostridium butyricum UCN-12 and composition and application thereof

Abstract

The invention discloses a novel strain Clostridium butyricum UCN-12 and a composition and application thereof. The preservation number of the novel strain in CGMCC (China General Microbiological Culture Collection Center) is CGMCC No.9652. As effective constituents fed to livestock, a fermentation culture of the strain, fermentation liquor or thalli obtained by centrifugating the fermentation culture and a dried product of the fermentation liquor or thalli have the effect of treating and/or preventing livestock clostridium welchii disease; no antibiotic is needed to be added in the whole process so that environment contamination caused by antibiotic residues is avoided; cholesterol and fat in eggs can be remarkably reduced, and eggy smell can be removed to improve the taste of eggs; the production performance of livestock is improved; and antenatal and puerperal constipation of sows can be treated and/or prevented to reduce smelly excrement of livestock and realize environment-friendly cultivation.

Description

technical field [0001] The invention belongs to the field of microbiology, and relates to a clostridium butyricum UCN-12 strain, a composition and application thereof. Background technique [0002] Clostridioides welchii, also known as Clostridium perfringens, is one of the most common diseases of foodborne gastroenteritis. According to foreign statistics, food poisoning caused by Clostridium welchii accounts for about 30% of bacterial food poisoning. The latest statistics show that the number of people with food poisoning caused by Clostridium perfringens in the United States is about 250,000 every year, and the economic loss caused by it reaches 120 million. Dollar. Epidemiological surveys found that an average of food poisoning outbreaks caused by Clostridium perfringens usually involve 50-100 people. Some severe food poisoning outbreaks have involved thousands of people. [0003] Clostridium welchii can generally be divided into six types: A, B, C, D, E, and F. Types ...

AI Technical Summary

Problems solved by technology

Due to the problem of drug resistance caused by long-term use of antibiotics, the use of antibiotics is getting higher and higher, but the treatment effect is getting worse and worse, and the environmental pollution is also increasing. In particular, the safety of drug residues is becoming more and more a concern of the whole society. The problem

Vaccine is a better way to prevent Clostridium welchii disease, but the protection period is short, and the cost is high, so it is unacceptable in production

[0006] Chinese patent application 201210390182.9 discloses a Chinese veterinary medicine for preventing and treating Clostridium welchii disease of piglets and a preparation method thereof. 5-15 parts, 10-20 parts of angelica, 10-20 parts of white peony, 1-5 parts of Panax notoginseng powder, 5-15 parts of ginseng stems and leaves, and 5-10 parts of licorice. This method is difficult to eliminate people's concerns about drug residues , and high cost

Patent application 201210552595.2 discloses a special feed containing Bacillus licheniformis, Bacillus subtilis, Enterococcus faecium, Streptococcus faecalis, and xylanase. Since Bacillus licheniformis and Bacillus subtilis interact with Enterococcus faecium and Streptococcus faecium, The compatibility of the composition is unreasonable, and the effect of this method is also poor

Patent applications 201310577204.7 and 201210261894.0 respectively disclose a strain of Bacillus subtilis and a strain of Bacillus licheniformis resistant to acid, heat, and bile salts to prevent and treat Clostridium welchii. The strains used are completely different from those of the present invention. Meanwhile, Bacillus subtilis and bacillus licheniformis belong to aerobic bacteria, need aeration culture, complicated process, and production cost is also higher than the present invention

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