Preparation method of sulfonylurea and sulfonamide formate compounds

A compound and alkyl technology, applied in the preparation of sulfonic acid amides, chemical instruments and methods, compounds containing elements of Group 3/13 of the periodic table, etc., can solve the problems of unfriendly environment, poor safety and high cost
CN104649945AActive Publication Date: 2015-05-27CHINA AGRI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHINA AGRI UNIV
Publication Date
2015-05-27

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Abstract

The invention relates to a preparation method of a compound represented by a formula (I). The compound is prepared by reacting a compound represented by a formula (II) with a compound represented by a formula (III) in a solvent under the catalysis of a palladium catalyst in carbon monoxide atmosphere, wherein X is O or N; N is 0 or 1; when X is O, n is equal to 0; when X is N, n is equal to 1; R1 is selected from aryl, heteroaryl, alkyl, alkenyl or alkynyl; R2 is selected from aryl, heteroaryl, alkyl, alkenyl or alkynyl; R3 is selected from H, R2 forms a ring, or R2 and R2 are linked to form a ring; R4 is N3 or a halogen atom; when R4 is the halogen atom, a system further contains sodium azide. The preparation method has the beneficial effects that the reaction does not require strict anhydrous and anaerobic conditions and high-pressure carbon monoxide atmosphere, the operation is convenient and simple, and the reaction has very good tolerance and universality to functional groups; meanwhile, the use level of a catalyst is extremely low, the reaction cost is very low, and the method can be widely applied to the preparation of sulfonylurea compounds.
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Description

technical field

[0001] The invention belongs to the field of organic synthesis, and in particular relates to a preparation method of sulfonylureas and sulfonamido formate compounds. Background technique

[0002] Sulfonylureas and sulfonamidocarbamate compounds are a very important class of organic compounds, which are widely used in the fields of medicine, pesticides and polymer functional materials. For example, in the field of medicine, sulfonylurea compounds can be effectively used in the treatment of type II diabetes, they bind the K on the membrane of pancreatic cells ATP channel, inhibiting the outflow of potassium ions, thereby increasing the release of insulin. Another example is in the field of pesticides, sulfonylurea compounds are an important class of herbicides, which selectively inhibit acetolactate synthase (ALS) / acetate hydroxyacid synthase (AHAS), low toxicity, high efficiency and high selectivity.

[0003] For a long time, people have been looking for sim...

Claims

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