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Molecularly imprinted porous magnetic cellulose microspheres on the surface of artesunate and its preparation method and application

A technology of surface molecular imprinting and porous cellulose, which is applied in the direction of microsphere preparation, microcapsule preparation, chemical instruments and methods, etc., can solve the problems of inability to complete integration, small adsorption amount, complicated steps, etc., and achieve magnetic response characteristics retention , increased adsorption capacity, uniform and stable magnetic response

Active Publication Date: 2017-06-16
EAST CHINA NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Aiming at the defects of the above-mentioned prior art, the present invention aims to solve the existing problems in the detection, separation and purification of artesunate, such as complex steps, long time-consuming, high cost, low adsorption capacity, and inability to complete integration, etc., and provides A rapid and simple detection, identification, separation and purification integration, reusable artesunate surface molecularly imprinted porous cellulose microspheres and its preparation method and application

Method used

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  • Molecularly imprinted porous magnetic cellulose microspheres on the surface of artesunate and its preparation method and application
  • Molecularly imprinted porous magnetic cellulose microspheres on the surface of artesunate and its preparation method and application
  • Molecularly imprinted porous magnetic cellulose microspheres on the surface of artesunate and its preparation method and application

Examples

Experimental program
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preparation example Construction

[0054] (1) Fe 3 o 4 Preparation of nanoparticles:

[0055] Iron Sulfate (Fe 2 (SO 4 ) 3 ) and ferrous sulfate (FeSO 4 ) was dissolved in deionized water except peroxygen, and 0.125mol / LFe 2 (SO 4 ) 3 solution and 0.1mol / L FeSO 4 The solutions were mixed at a volume ratio of 1.25:1, and sonicated for 0.5 h at 25° C. under nitrogen protection. Slowly add concentrated sodium hydroxide solution (0.5-1 mol / L) dropwise into the solution, adjust the pH of the mixed solution to 10-12, and continue to sonicate for 0.5 h. Raise the temperature to 60°C, and sonicate for 1 h under nitrogen protection. will generate Fe 3 o 4 Stand still, use magnet to separate and recover, wash 3 times alternately with acetone and water, get Fe 3 o 4 Nanoparticles.

[0056] (2) Preparation of magnetic cellulose solution:

[0057] Freeze the alkali / urea aqueous solution to -15-0°C, then add cellulose, stir vigorously to dissolve the cellulose, and remove impurities by centrifuging to obtain ...

Embodiment 1

[0063] Example 1 Preparation of Molecularly Imprinted Porous Cellulose Microspheres on the Surface of Artesunate

[0064] (1) Fe 3 o 4 Preparation of nanoparticles:

[0065] After 100ml of distilled water at room temperature is ultrasonicated at 40kHz for 5-10min, add 0.0125mol of Fe 2 (SO 4 ) 3 powder and 0.01mol FeSO 4Powder, prepare 0.125mol / L Fe 2 (SO 4 ) 3 solution and 0.1mol / L FeSO 4 solution, according to Fe 2 (SO 4 ) 3 : FeSO 4 Mixed at a molar ratio of 1.25:1. Continue to sonicate at 25°C under nitrogen protection to obtain a uniformly mixed solution. , slowly drop NaOH solution with a concentration of 1.0 mol / L to adjust the pH value of the solution to 12, and continue to sonicate for 0.5 h. Raise the temperature to 60°C, and sonicate for 1 h under nitrogen protection. Wherein, the ultrasonic power is 40kHz. will generate Fe 3 o 4 Stand still, use magnet to separate and recover, wash 3 times alternately with acetone and water, get Fe 3 o 4 Nanopa...

Embodiment 2

[0074] Example 2 Determination of the Adsorption Performance of Molecularly Imprinted Porous Cellulose Microspheres on the Surface of Artesunate

[0075] Draw the standard curve of artesunate by ultraviolet-visible spectrophotometer: use DMSO solution as solvent, and the preparation concentration is 10 -4 -10 -5 mol / L(10 -5 , 2x10 -5 , 3x10 -5 , 4x10 -5 , 5x10 -5 , 6x10 -5 , 7x10 -5 , 8x10 -5 , 9x10 -5 , 10 -4 ) gradient concentration of artesunate solution, the UV maximum absorbance value corresponding to the peak value is 238nm, draw the artesunate concentration and the corresponding absorbance value at 238nm, and obtain a linear regression equation: Y=0.20209X R 2 =0.996, where X represents the concentration of artesunate, and Y represents the corresponding absorbance value at the maximum UV peak at 238nm. The linear relationship between artesunate absorbance intensity and concentration, such as Figure 7 shown.

[0076] The method for measuring the molecularly...

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Abstract

The invention relates to a molecularly imprinted porous magnetic cellulose microsphere on the surface of artesunate, which is prepared from artesunate, acrylamide, methacrylic acid, magnetic cellulose microspheres, an initiator and water. Dissolving cellulose by alkaline urine system to prepare Fe 3 o 4 Fluid, porous magnetic cellulose microspheres, thereby preparing porous cellulose microspheres with molecular imprinting on the surface of artesunate. Molecularly imprinted porous cellulose microspheres on the surface of artesunate in the present invention are used as an adsorbent for selectively identifying and adsorbing artesunate, can quantitatively detect artesunate, and can separate and purify the substance. The microspheres can Recycle and reuse.

Description

technical field [0001] The invention belongs to the technical field of preparation and application of polymer functional materials, and relates to a method for preparing surface molecularly imprinted porous magnetic cellulose. The prepared surface molecularly imprinted porous magnetic cellulose microspheres are used to detect, separate and purify plants, medicines and natural Artesunate in the environment. Background technique [0002] Cellulose is one of the abundant and renewable natural resources on the earth. It has the characteristics of cheapness, biodegradability, good biocompatibility, and non-toxicity. It has been widely studied at home and abroad. Porous cellulose microspheres have low density, large surface area, and controllable size due to the pores on the surface of the microspheres connected to the internal cavity. Using the cavity to fill magnetic substances, conductive materials, catalysts, and drugs makes it an important It is one of the functional materia...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F251/02C08F220/06C08F220/56C08F222/38C08F2/44C08K3/22C08J9/28C01G49/08B01J13/04B01J20/26B01J20/30G01N21/33
Inventor 徐敏黄海龙宋建会葛昊冯智莹王敏潘斐张艳艳张惠东胡牧云罗雪娇温夏夏
Owner EAST CHINA NORMAL UNIV
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