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Preparation method of calcium alginate nanometer microspheres

A technology of nano-microspheres and calcium alginate, which is applied to medical preparations and pharmaceutical formulations with non-active ingredients, can solve the problems of organic solvent residues, toxicity hazards and other problems that are difficult to avoid in the treatment process, and achieves little difference between batches and no Organic solvent, effect of uniform particle size distribution

Inactive Publication Date: 2015-06-17
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0003] The preparation methods of the existing alginic acid drug carrier include solvent emulsification steam method, ultrasonic emulsification method and high pressure emulsion method, etc., the organic solvent or relatively large amount of surfactant added in the preparation process of the above method requires subsequent treatment process, which is difficult to avoid Residues of organic solvents, potentially toxic hazards

Method used

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  • Preparation method of calcium alginate nanometer microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Weigh 0.3g of sodium alginate and place it in 25g of water to swell for 8 hours, stir and dissolve fully to obtain the aqueous phase mixed solution a; dissolve 15g of soybean lecithin and 15g of absolute ethanol in 45g of isopropyl myristate and mix evenly to obtain the oil phase Mix solution b; mix a and b two phases at room temperature, stir at 10000r / min at high speed for 10 minutes, use a high-pressure homogenizer to homogenize at 50Mpa for 10 minutes to obtain a transparent / translucent W / O submicroemulsion solution, and measure it with a laser particle size analyzer Submicron emulsion particle size distribution (attached figure 1 ), the average particle size is 64.29nm, and the polydispersity index PDI is 0.099. Weigh 0.15gCaCl 2 Dissolve in 10mL water to prepare solidified solution; take 10mL submicron emulsion solution, add solidified solution drop by drop into submicron emulsion solution under 1000r / min magnetic stirring state, solidify for 20min and leave to s...

Embodiment 2

[0029] Weigh 0.05g of sodium alginate and place it in 10g of water to swell for 6 hours, stir and dissolve fully to obtain the aqueous phase mixed solution a; dissolve 18g of polyethylene glycol caprylic glycerin and 18g of PEG-400 in 54g of ethyl oleate Mix evenly to obtain oil phase mixed solution b; mix a and b at room temperature, stir at 10000r / min at high speed for 10min, and homogenize with a high-pressure homogenizer at 50Mpa for 20min to obtain a transparent / translucent W / O submicroemulsion solution, laser particle size The particle size distribution of submicron emulsion was determined by instrument. Weigh 0.1gCaCl 2 Dissolve in 10mL of water to prepare the solidified solution; take 10mL of the submicron emulsion solution, add the solidified solution dropwise to the submicron emulsion solution under 1000r / min magnetic stirring state, solidify for 10min and let it stand for stratification, then discard the upper oil phase to obtain seaweed Calcium Oxide Nanospheres. ...

Embodiment 3

[0031] Weigh 0.32g of sodium alginate and place it in 16g of water to swell for 6 hours, stir to dissolve fully to obtain the aqueous phase mixed solution a; Oil phase mixed solution b; mix the two phases a and b at room temperature, stir at 10000r / min at high speed for 10 minutes, and use a high-pressure homogenizer at 60Mpa to homogenize for 15 minutes to obtain a transparent / translucent W / O submicroemulsion solution. Microemulsion particle size distribution and average particle size. Weigh 0.3gCaCl 2 Dissolve in 10mL water to prepare solidified solution; take 10mL submicron emulsion solution, add solidified solution drop by drop into submicron emulsion solution under 1000r / min magnetic stirring state, solidify for 20min and leave to separate layers, then discard the upper oil phase to obtain seaweed Calcium Oxide Nanospheres.

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Abstract

The invention relates to calcium alginate nanometer microspheres and a preparation method thereof. The preparation method of the nanometer microspheres comprises the following specific preparation steps: using a natural polysaccharide material sodium alginate as a raw material, adopting high-pressure homogenization method to be combined with an external gelation method, and preparing the calcium alginate nanometer gel microspheres. The particle size of the nanometer gel microspheres prepared by applying the method is in a range of 50-1000 nm, and the particle size distribution is uniform. Compared with a traditional emulsification-external gelation method, the nanometer microspheres prepared by the high-pressure homogenization method has uniform particle size distribution and high yield; during the preparation process, no organic solvent is required to be added, the amount of an emulsifier is greatly reduced, and the preparation method is green, environmentally friendly, safe and nontoxic; and the calcium alginate nanometer microspheres are simple and convenient to prepare and can be prepared on large scale.

Description

technical field [0001] The invention relates to a preparation method of calcium alginate nano microspheres. Specifically, it is a method for preparing calcium alginate nano-microspheres by using high-pressure homogeneity combined with an external gelation method. technical background [0002] Due to their good biocompatibility and bioactivity, natural polysaccharide materials have been widely concerned and applied in the fields of biology and medicine in recent years. Alginate is a natural polysaccharide compound derived from brown algae. It has a wide range of sources, is safe and non-toxic, and is often used as a stabilizer and thickener in the food and pharmaceutical industries because it can solidify with divalent and trivalent ions to form a gel. , gel matrix, film material, blocker, etc. With the development of pharmaceutical preparation research, alginate has been more and more used in slow and controlled release of drugs, especially micro / nano slow and controlled re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/12C08J3/03C08L5/04A61K47/36
Inventor 马小军赵姗谢红国吕国军吕岩于炜婷
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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