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Preparation method and application of rare earth up-conversion drug-delivery nano-carrier

A rare earth up-conversion and nano-carrier technology is applied in the field of medicine to achieve the effects of high yield, simple operation and short preparation period

Inactive Publication Date: 2015-07-15
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, pharmaceutical preparations that can simultaneously achieve "timed, quantitative, and localized release of drugs, and reduce toxic and side effects" have not yet been found in related articles and patent reports.

Method used

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  • Preparation method and application of rare earth up-conversion drug-delivery nano-carrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] 1. Synthesis of Rare Earth Upconversion Nanoparticles (UCN):

[0058] (1) Weigh 200 mg of ytterbium chloride, 700 mg of ytterbium chloride and 10 mg of erbium chloride, add the above three substances to 4 ml of water, and heat to boiling under magnetic stirring conditions until the rare earth salt solution becomes a white solid.

[0059] (2) After the water is evaporated to dryness, cool it slightly (below 50°C) and add 10 mL of oleic acid ligand solution and 5 mL of octadecene ligand solution with a pipette to completely dissolve the white solid;

[0060] (3) Then add 60mg NaOH and 30mg ammonium fluoride, dissolve it with 5ml methanol; adjust the temperature to 150°C, use oil pump to vacuum for 15min, and argon; quickly raise the temperature to 250°C and maintain the reaction for 2 hours; add acetone after the end Centrifugal purification, the final product is vacuum dried and stored. The prepared rare earth up-conversion nanoparticles have a diameter of 20 nm. image 3 : Ra...

Embodiment 2

[0071] 1. Synthesis of Rare Earth Upconversion Nanoparticles (UCN):

[0072] a) The above-mentioned up-conversion nanoparticles are prepared by solvothermal method:

[0073] (1) Weigh 250 mg of ytterbium chloride, 100 mg of ytterbium chloride and 5 mg of erbium chloride, add the above three substances to 4 ml of water, and heat to boiling under magnetic stirring conditions until the rare earth salt solution becomes a white solid.

[0074] (2) After the water evaporates to dryness, cool it slightly (below 80°C) and use a pipette to add 60 mL of oleic acid ligand solution and 10 mL of octadecene ligand solution to completely dissolve the white solid;

[0075] (3) Then add 15mg NaOH, 15mg ammonium fluoride, dissolve with 5ml methanol; adjust the temperature to 100℃, use oil pump to vacuum for 10min, ventilate with argon; quickly raise the temperature to 270℃, maintain the reaction for 1 hour; add acetone after completion Centrifugal purification, the final product is vacuum dried and sto...

Embodiment 3

[0086] 1. Synthesis of Rare Earth Upconversion Nanoparticles (UCN):

[0087] (1) The above-mentioned up-conversion nanoparticles were prepared by solvothermal method: Weigh 30 mg of ytterbium chloride, 50 mg of yttrium chloride and 1 mg of erbium chloride, add the above three substances to 4 ml of water, and heat to Boil until the rare earth salt solution becomes a white solid.

[0088] (2) After the water evaporates to dryness, cool it slightly (below 60°C) and use a pipette to add 20 mL of oleic acid ligand solution and 5 mL of octadecene ligand solution to completely dissolve the white solid;

[0089] (3) Then add 1mg NaOH, 3mg ammonium fluoride, dissolve it with 5ml methanol; adjust the temperature to 120℃, use oil pump to vacuum for 40min, ventilate with argon; quickly raise the temperature to 300℃, maintain the reaction for 3 hours; add acetone after completion Centrifugal purification, the final product is vacuum dried and stored. The prepared rare earth up-conversion nanopa...

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Abstract

The invention relates to a preparation method and application of a rare earth up-conversion light-operated drug-delivery nano-carrier. The preparation method comprises the following steps: with a variety of rare earth salts as raw materials, preparing a rare earth up-conversion nanoparticle through a solvothermal process; synthesizing meso-porous silicon via a template process and carrying out coating; connecting a silane reagent to the surface of a meso-porous silicon shell layer; and finally, embedding a drug into meso pores. The nano-carrier prepared in the invention has a targeted aggregation effect and can realize precise positioning at a tumor site. The nano-carrier has a light-operated release effect; the drug is stored in the nano-carrier under the condition of no external near infrared laser (with wavelength of 980 nm) irradiation; the chemotherapy drug can only be released when a near infrared excitation source irradiates tumor tissue; thus, precise, timed and quantitative release of the nano-carrier at a tumor site can be realized. The nano-carrier has a fluorescence imaging function, can realize visualization of chemotherapy process and has the advantages of simple operation, good applicability, low cost and good dispersibility in water.

Description

Technical field [0001] The invention relates to a preparation method and application of a rare earth up-conversion light-controlled drug release nano-carrier, and belongs to the technical field of medicine. Background technique [0002] Chemotherapy is one of the important methods for the treatment of malignant tumors. Become the three major treatment methods alongside surgery and radiotherapy. Tumor chemotherapy specifically refers to the application of chemical drugs (including endocrine drugs) to treat malignant tumors. Anti-cancer drugs are quickly distributed throughout the body after entering the body, and can kill local tumors as well as distant metastatic tumors. Therefore, chemotherapy is a systemic treatment. [0003] However, due to the defects of "uncertain time, uncertain total amount and uncertain position" of drug release in the traditional chemotherapy process, clinical medication can only achieve the therapeutic effect through "high frequency, high dose and syste...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/04A61K47/22A61K31/704A61P35/00
Inventor 王汉杰侯贝贝常津宫晓群董春红刘俊庆
Owner TIANJIN UNIV
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