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Sodium alginate/starch-based enteric-coated hollow capsule and its one-time molding preparation method

A technology of sodium alginate and hollow capsule, applied in the direction of capsule transportation, can solve the problems of complex production process, etc., and achieve the effects of high transparency, good film-forming property and good film-forming property

Inactive Publication Date: 2018-01-30
ZHEJIANG WANLI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such as CN103877587A discloses a kind of medicinal enteric-coated hard-shell capsule of plant polysaccharide and preparation method thereof, is raw material with sodium alginate, CMC, polyethylene glycol, prepares enteric-coated hollow capsule by secondary calcification molding, and production process is relatively complex

Method used

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  • Sodium alginate/starch-based enteric-coated hollow capsule and its one-time molding preparation method
  • Sodium alginate/starch-based enteric-coated hollow capsule and its one-time molding preparation method
  • Sodium alginate/starch-based enteric-coated hollow capsule and its one-time molding preparation method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The one-time molding preparation method of the sodium alginate / starch-based enteric-coated hollow capsule of embodiment 1 comprises the following steps:

[0028] 1) Ingredients, sol: According to 63.8% of starch, 3.8% of high viscosity sodium alginate with a viscosity of 450mPa·s, 15.9% of low viscosity sodium alginate with a viscosity of 5mPa·s, 3.8% of low acyl gellan gum, glycerin (ie Glycerol) 12.7% weight percentage carries out the batching of each raw material, and all raw materials are mixed with 100g deionized water, and sol in the constant temperature water bath of 80 ℃, proper stirring makes raw material absorb water and swell and dissolve in the sol process 1.5 hours;

[0029] 2) Degassing of gelatinization: After the sol is completed, put the gelatinization in a constant temperature water bath at 55°C for 3 hours for degassing, and set aside;

[0030] 3) Embryo dipping in glue: Select a suitable type of capsule mold, first apply an appropriate amount of sal...

Embodiment 2

[0032] The one-time molding preparation method of the sodium alginate / starch-based enteric-coated hollow capsule of embodiment 2 comprises the following steps:

[0033] 1) Ingredients and sol: 65% starch, 3.5% high-viscosity sodium alginate with a viscosity of 450mPa·s, 16% low-viscosity sodium alginate with a viscosity of 5mPa·s, 3.8% low-acyl gellan gum, and 11.7% glycerin The weight percentage of each raw material was mixed, and all raw materials were mixed with 100g deionized water, and sol was carried out in a constant temperature water bath at 85°C. During the sol process, the raw materials were properly stirred to absorb water and swell and dissolve for 2 hours;

[0034] 2) Degassing of gelatinization: After the sol is completed, put the gelatinization in a constant temperature water bath at 60°C to degas for 2.5 hours, and set aside;

[0035] 3) Embryo dipping in glue: Select a suitable type of capsule mold, first smear an appropriate amount of corn oil on the surface of...

Embodiment 3

[0037] The one-time molding preparation method of the sodium alginate / starch-based enteric-coated hollow capsule of embodiment three comprises the following steps:

[0038] 1) Ingredients and sol: 70% starch, 2.2% high-viscosity sodium alginate with a viscosity of 450mPa·s, 14.5% low-viscosity sodium alginate with a viscosity of 5mPa·s, 5% gellan gum, and 11.7% glycerol The weight percentage of each raw material was mixed, and all raw materials were mixed with 100g deionized water, and sol was carried out in a constant temperature water bath at 75°C. During the sol process, the raw materials were properly stirred to absorb water and swell and dissolve for 2 hours;

[0039] 2) Degassing of gelatinization: After the sol is completed, put the gelatinization in a constant temperature water bath at 58°C to degas for 2.5 hours, and set aside;

[0040] 3) Embryo dipping in glue: select a suitable type of capsule mold, first apply an appropriate amount of corn oil on the surface of th...

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Abstract

The sodium alginate / starch-based enteric hollow capsule disclosed in the present invention includes a capsule body, and the weight percentage of the capsule body comprises: 15-30% of sodium alginate, 60-75% of starch, and 3-10% of gelling agent , Plasticizer 6~15%, Moisture 9.95~11.5%. The hollow capsules of the invention can completely get rid of the dependence of the hollow capsules on animal-derived raw materials, and belong to the plant-type enteric hollow capsules in the true sense. The preparation method for enteric-coated hollow capsules of the present invention does not require secondary enteric coating or calcification of the capsule embryos in the preparation process, and only needs to be dipped in glue to prepare enteric-coated capsule embryos, which can simplify the enteric-coated hollow capsules The latest production process can meet the existing hollow capsule production line, and it is not necessary to configure a special production line, which can greatly reduce the production cost of the product. The enteric-coated hollow capsules prepared by the method of the present invention have low cost of raw materials, no cracks and no disintegration in the stomach with a pH value of 0.9-1.5 for 2 hours, and 30 minutes in the intestinal tract with a pH value of 6.8-8.2 It can be completely disintegrated within the characteristics.

Description

technical field [0001] The invention relates to an enteric-coated hollow capsule and its preparation, in particular to a novel compound plant source type sodium alginate / starch-based enteric-coated hollow capsule and a preparation method thereof. Background technique [0002] Due to the problems of expensive raw materials and limited application of gelatin hollow capsules, plant-derived hollow capsules have gradually become the development direction of the capsule industry. Capsules have been successfully developed and some are marketed. As for the enteric-coated empty capsules, currently, the existing enteric-coated empty capsules on the market include gelatin enteric-coated empty capsules and hypromellose enteric-coated empty capsules. Dissolving coating (mainly enteric-coated acrylic resin, cellulose acetate titanate and other raw materials) or gelatin cross-linking reaction with formaldehyde is prepared. These two types of enteric-coated hollow capsules require seconda...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/36
Inventor 刘利萍钱国英路春玲
Owner ZHEJIANG WANLI UNIV
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