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Nanometer/micrometer fiber three-dimensional porous structure support material and preparation and application of support material

A microfiber, three-dimensional porous technology, applied in medical science, prosthesis, etc., to achieve the effect of easy-to-obtain raw materials, simple preparation methods, and excellent biocompatibility

Inactive Publication Date: 2015-09-09
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the three-dimensional composite scaffold has a certain strength and thickness, and finally a three-dimensional bone regeneration scaffold with practical value is prepared; at present, there is no literature report that after the nanofibrous membrane and the micron fiber mesh are stacked layer by layer, they are reinforced by acupuncture technology to prepare biomedical Tissue Engineering Scaffolds

Method used

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  • Nanometer/micrometer fiber three-dimensional porous structure support material and preparation and application of support material
  • Nanometer/micrometer fiber three-dimensional porous structure support material and preparation and application of support material
  • Nanometer/micrometer fiber three-dimensional porous structure support material and preparation and application of support material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] To prepare a polycaprolactone electrospinning solution, 1.2 g of polycaprolactone (PCL) particles and 0.8 g of collagen (collagen) powder were added to 10 mL of trifluoroethanol. Magnetic stirring was carried out at room temperature for 24 hours to obtain a PCL spinning solution containing 40% HAp. During electrospinning, a 5mL syringe was used, a 21G stainless steel needle was used, the applied voltage was 15kV, the receiving distance was 15cm, and the spinning time was 1.5h to obtain 4 nanocomposite membranes containing PCL / collagen.

[0032] Get 15g of natural degummed silk and go through the carding machine for twice carding to get 3 pieces with a surface density of 5g / m 2 micron fiber web. The 7-layer composite material is obtained by superimposing the nanofiber membrane and the micron fiber net layer by layer. First, it undergoes pre-acupuncture with a frequency of 500 needles / min and a needle depth of 6mm; then it undergoes main acupuncture with a frequency of 5...

Embodiment 2

[0035] Preparation of 40% hydroxyapatite biomimetic natural bone structure nano-hydroxyapatite / micron fiber three-dimensional porous bone tissue engineering scaffold:

[0036] When preparing the polycaprolactone electrospinning solution, 1.2g of polycaprolactone (PCL) particles and 0.8g of nano-hydroxyapatite (HAp) powder were added to 10mL of trifluoroethanol. Magnetic stirring was carried out at room temperature for 24 hours to obtain a PCL spinning solution containing 40% HAp. During electrospinning, a 5mL syringe, a 21G stainless steel needle, an applied voltage of 15kV, a receiving distance of 15cm, and a spinning time of 1.5h were used to obtain 15 PCL nanomembranes containing 40% HAp. Another 140 collagen or silk fiber is taken, and the surface density is 14 pieces of 10g / m by carding twice. 2micron fiber web. The 29-layer composite material is obtained by superimposing the nanofiber membrane and the micron fiber net layer by layer. First, it undergoes pre-acupuncture...

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Abstract

The invention relates to a nanometer / micrometer fiber three-dimensional porous structure support material, and preparation and application of the support material. The support material is obtained by overlaying nanometer fiber membranes and micrometer fiber webs layer by layer and by needle-punched reinforcement. The preparation of the support material comprises: flatly laying a nanometer fiber membrane on a nethermost layer; covering the fiber membrane with a micrometer fiber web; overlaying the nanometer fiber membranes and the micrometer fiber webs layer by layer to obtain a nanometer / micrometer composite material; and performing needle-punched reinforcement to obtain the nanometer / micrometer fiber three-dimensional porous structure support material. An artificial support obtained in the invention is excellent in biocompatibility; the problem of cell permeation through the nanometer fiber membranes is solved; and excellent biomechanical properties of the support are maintained, so that the support material has bright application prospects in clinical.

Description

technical field [0001] The invention belongs to the field of scaffold materials and their preparation and application, in particular to a nano / micro fiber three-dimensional porous structure scaffold material and its preparation and application. Background technique [0002] Because humans cannot heal large bone injuries by themselves, they must be treated with the intervention of repair surgery. Currently, autologous bone grafting remains the gold standard for the treatment of bone injuries. However, autologous bone grafts have many drawbacks, such as pain, inflammation and bleeding at the donor site. In order to solve these problems, the natural repair of damaged bone induced by tissue engineering has become a hotspot of current research. Electrospinning technology is a method with simple equipment and convenient operation, which can easily prepare nano- or micron-sized fibers. It has shown great advantages in biomimetic human natural extracellular matrix (ECM), but ther...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/24A61L27/22A61L27/20A61L27/18A61L27/54
Inventor 柯勤飞李昊轩黄晨何南霏
Owner DONGHUA UNIV