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A kind of composition for promoting protein synthesis and preparation method and use thereof

A technology of protein synthesis and composition, applied in the field of medicine and biology, can solve the problems of low content, single component, unsatisfactory medicinal effect, etc., achieve high extraction rate, high product quality, and improve the effect of drug utilization

Active Publication Date: 2018-02-23
杨克西
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are products containing β-cryptoxanthin on the market, their content is relatively low. For example, the content of β-cryptoxanthin sold by COTION is only 0.2%, and its ingredients are relatively single. The effect is not ideal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Preparation of concentrates containing β-cryptoxanthin according to the present invention

[0030] Take the original medicine of the calyx physalis, wash it, dry it away from light, crush it, mix it evenly, and pass it through a 20-200 mesh sieve to obtain the calyx physalis powder. Under an inert gas atmosphere, according to the mass ratio of the calyx physalis and water 1:30, the amount of the mixed enzyme of cellulase and pectinase accounted for 3% of the total weight of the calyx physalis powder, and the enzymatic hydrolysis solution was prepared , wherein the mass ratio of cellulase and pectinase is 1:7. Stir, use hydrochloric acid or sodium hydroxide solution to adjust the pH of the enzymolysis solution to 6, put it in a constant temperature shaker, the shaker speed is 100~120rpm, and carry out the enzymolysis at 45°C for 100min. Filtrate, dry, weigh the dried enzyme-treated Physalis calyx powder, and use supercritical CO2 extraction method, under the ...

Embodiment 2

[0031] Embodiment 2: the preparation of composition of the present invention

[0032] According to the quality of β-cryptoxanthin in the concentrate obtained in Example 1, sodium cholate, sodium glycocholate, sodium taurocholate, potassium glycodeoxycholate were added respectively according to a mass ratio of 1:1, and mixed , Stir evenly to obtain the composition of the present invention.

reference example 1

[0033] Reference example 1: Characterization of the ability to promote protein formation

[0034] Since the growth of fish is actually completed through protein synthesis, white muscle is the tissue with the highest protein synthesis and deposition in fish, and it is the most representative tissue representing the growth of fish. Therefore, commercially available carp fry were selected as the experimental subjects to evaluate the effect of the pharmaceutical composition of the present invention on protein synthesis.

[0035] According to the addition amount of 20mg / Kg, the concentrate obtained in Example 1 and the composition obtained in Example 2 were respectively added to commercially available fish feed, mixed evenly, crushed to 1.5mm, and dried for later use. Buy 100 carp fry with neat specifications on the market, place them in net cages for domestication, and gradually transition from commercially available feed to the above-mentioned compound feed. After all of the com...

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PUM

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Abstract

The application relates to the field of biotechnology, in particular to a composition, use and preparation method. Composition containing beta-cryptoxanthin concentrate and bile salts from calyx physalis, together with DL-ALPHA-tocopherol and / or sodium ascorbate, effective in promoting protein synthesis in human and animal tissues and preventing aging Or muscle loss during treatment. The composition of the invention has easy-to-obtain raw materials, simple preparation process, high-quality product, controllable comprehensive cost and is suitable for industrial production.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing β-cryptoxanthin for promoting and / or improving protein synthesis in organisms, and belongs to the field of medical biotechnology. Background technique [0002] β-cryptoxanthin is a carotenoid, its molecule is composed of a central conjugated polyene chain and a terminal six-membered ring, and there is a single hydroxyl group on one of the terminal six-membered rings, the molecule is asymmetric, and the all-trans isomers are the most stable. β-cryptoxanthin usually exists in the form of monomers or esters in the flower or fruit tissues of higher plants such as oranges, red peppers, and physalis. Studies have shown that β cryptoxanthin can enhance and improve protein synthesis in human animal tissues, such as liver, skin, muscle, etc., and can also be used for general strengthening of growth and development during exercise, training, and rehabilitation, as well as for Prevention and treat...

Claims

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Application Information

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IPC IPC(8): A61K31/575A61P3/02A61P21/00A61K31/07
Inventor 杨克西王炜颜丙春王芬
Owner 杨克西