Antineoplastic polypeptide nanometer drug, preparation method and application thereof

A nano-drug and anti-tumor technology, applied in anti-tumor drugs, drug combinations, pharmaceutical formulations, etc., can solve the problems of molecular structure damage, insufficient stability, etc., and achieve extended half-life, improved bioavailability, and good compatibility Effect
CN104940949AActive Publication Date: 2015-09-30THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
Publication Date
2015-09-30

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Abstract

The invention provides an antineoplastic polypeptide nanometer drug, and a preparation method and application thereof. The antineoplastic polypeptide nanometer drug comprises amphipathic antineoplastic polypeptides and acid responsiveness functional molecules link-coupled with the amphipathic antineoplastic polypeptides. Amino acid is taken as the raw material to synthesize amphipathic polypeptide molecules, and then acid responsiveness functional molecules are introduced into the amphipathic antineoplastic polypeptide molecules to be subjected to self-assembling to form the antineoplastic polypeptide nanometer drug. The antineoplastic polypeptide nanometer drug provided by the invention has good biocompatibility, smaller toxic and side effects, acid responsiveness, high bioavailability and high biosecurity. The preparation method provided by the invention is simple, covalent bonds are not produced in the self-assembling process, reverse reaction is avoided, and the prepared antineoplastic polypeptide nanometer drug has a broad application prospect.
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Description

technical field

[0001] The invention relates to the field of nano-medicine, and relates to an anti-tumor polypeptide nano-medicine and a preparation method and application thereof. Background technique

[0002] In recent years, the research and development of anti-tumor peptide drugs has attracted much attention. Compared with antibodies and small-molecule drugs, peptide drugs have low immunogenicity, high receptor binding rate, low preparation cost, and are easy to modify and combined application. Organ metabolism. Therefore, improving the pharmacokinetics of polypeptides without reducing their efficacy is an important direction for the development of polypeptide drugs.

[0003] Nano-drugs are emerging drug dosage forms. By designing and regulating the nano-characteristics of organic or inorganic materials, nano-carriers with stable structures, diverse functions and good biocompatibility can be prepared, which can significantly prolong the half-life of drugs, improve targ...

Claims

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