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Method for preparing taurine through solid isethionic acid sodium salt

A technology of sodium isethionate and taurine, which is applied in the fields of sulfonic acid preparation, sulfonate preparation, organic chemistry, etc., and can solve problems such as environmental pollution

Inactive Publication Date: 2015-09-30
QIANGJIANG YONGAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The main purpose of the present invention is to provide a method for preparing taurine with solid sodium isethionate, by concentrating and crystallizing the addition liquid, water-soluble impurities (comprising ethylene glycol and ethylene glycol) in the addition liquid are removed. Various polymers of diols) improve the overall quality of the addition liquid, thus effectively avoiding some side reactions in the synthesis reaction, the quality, crystal form and yield of the product have been significantly improved, and the extraction has been realized at the same time All the mother liquors are used mechanically, which solves the problem of environmental pollution caused by the discharge of the taurine extraction mother liquor that cannot be well utilized in the traditional process.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] will be 6.0m 3 , 42wt% of the addition liquid is transported to the first-effect evaporator and concentrated to 5m 3 , 47 wt%, into the second effect evaporator, concentrated to 4.2m 3 , 55 wt%, into the three-effect evaporator, concentrated to 3.0m 3 , 70%, and then enter the continuous crystallizer. After 1~3h, the solid sodium hydroxide 2.8T is separated by a fully automatic centrifuge at 50~60°C. Put 2.8T solid sodium hydroxide into 5 m 3 In the batching tank, add 3.5 m 3 Dilute ammonia water, the total volume of the material is 4.8 m 3 , will be 4.8 m 3 The material is transported to the ammonia reactor, replenished with water and ammonia until the ammonia content is 20 wt%, and the total volume of the material after the ammonia is 20 m 3 . The material after the ammonia pass through 5 m 3 The flow rate of / h enters the high temperature and high pressure synthesis tower, the tower temperature is controlled at 252°C, and the pressure is controlled at 20.0MP...

Embodiment 2

[0029] will be 3.2m 3 , 43wt% of the addition liquid is transported to the first-effect evaporator and concentrated to 2.6m 3 , 48 wt%, into the second effect evaporator, concentrated to 2.2m 3 , 56 wt%, into the three-effect evaporator, concentrated to 1.6m 3 , 72%, and then enter the continuous crystallizer, after 1~3h, at 50~60℃, the solid sodium hydroxide 1.5T is separated by a fully automatic centrifuge. Put 1.5T solid sodium hydroxide into 3m 3 In the batching tank, add 1.8m 3 Dilute ammonia water, the total volume of the material is 2.6m 3 , will be 2.6 m 3 The material is transported to the ammonia reactor, replenished with water and ammonia until the ammonia content is 21 wt%, and the total volume of the material after the ammonia is 10 m 3 . The material after the ammonia pass through 5m 3 The flow rate of / h enters the high temperature and high pressure synthesis tower, the tower temperature is controlled at 256°C, and the pressure is controlled at 21.0MPa....

Embodiment 3

[0033] will be 3.2m 3 , 40wt% of the addition liquid is transported to the first-effect evaporator and concentrated to 2.6m 3 , 47 wt%, into the second effect evaporator, concentrated to 2.2m 3 , 55 wt%, into the three-effect evaporator, concentrated to 1.6m 3 , 70%, and then enter the continuous crystallizer, after 1~3h, at 50~60℃, the solid sodium hydroxide 1.5T is separated by a fully automatic centrifuge. Put 1.5T solid sodium hydroxide into 3 m 3 In the batching tank, add 1.8 m 3 dilute ammonia, the total volume of the material is 2.6 m 3 , will be 2.6 m 3 The material is transported to the ammonia reactor, replenished with water and ammonia until the ammonia content is 20 wt%, and the total volume of the material after the ammonia is 10 m 3 . The material after the ammonia pass through 4.5 m 3 The flow rate of / h enters the high temperature and high pressure synthesis tower, the tower temperature is controlled at 258°C, and the pressure is controlled at 21.0MPa....

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Abstract

The invention provides a method for preparing taurine through solid isethionic acid sodium salt. The method includes the following steps that continuous concentration and crystallization are conducted on addition liquid prepared by enabling sodium hydrogen sulfite to react with ethylene oxide, dissolution is conducted through the solid isethionic acid sodium salt obtained in a centrifugal mode, ammonia is fed, sodium taurate is obtained through a high-temperature high-pressure synthetic reaction, finally, sulfuric acid neutralization and extraction are conducted on, solid taurine is obtained, sodium taurate is regenerated by applying mother liquor to the synthetic reaction indiscriminately, and zero emission of taurine mother liquid is achieved. According to the method, concentration and crystallization are conducted on the addition liquid, water-soluble impurities in the addition liquid are removed, and the overall quality of the addition liquid is improved, so that the impurities generated in the synthesis reaction are reduced effectively, the quality, the crystal form and the yield of products can be improved remarkably, meanwhile, indiscriminate application of all of the mother liquor is achieved, and the problem that in a traditional process, the environment is polluted due to the fact that extracted taurine mother liquor cannot be well utilized and is discharged is well solved.

Description

technical field [0001] The invention belongs to the technical field of organic chemical synthesis, and in particular relates to a method for preparing taurine with solid sodium isethionate. Background technique [0002] Taurine is a non-protein amino acid. As a drug, it has the effects of anti-inflammatory, antipyretic, analgesic, anti-convulsant and lowering blood pressure. It has a good effect on infant brain development, nerve conduction, visual function improvement and calcium absorption. , taurine has a series of unique functions on the cardiovascular system, can enhance physical fitness, relieve fatigue, so taurine is gradually widely used in medical, food and health care and other fields. [0003] Taurine can be prepared by biological extraction and chemical synthesis. The former is rarely used due to the influence of raw materials and cost; at present, ethanolamine esterification method and ethylene oxide method are mainly used in industrial production. Compared wit...

Claims

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Application Information

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IPC IPC(8): C07C309/14C07C303/02C07C303/32C07C303/22
Inventor 方锡权周巍李少波蒋小军
Owner QIANGJIANG YONGAN PHARMA
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