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Halamine-pyridine salt double-function group polysiloxane bactericide, and preparation method and application thereof

A technology of halamine pyridine salt and bactericide, which is applied in the field of polymer synthesis, can solve the problems of limited bactericidal ability, and achieve the effect of perfect protection, low application risk and strong killing effect

Active Publication Date: 2015-10-07
SHANDONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since they are of the same type, there is limited improvement in bactericidal ability

Method used

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  • Halamine-pyridine salt double-function group polysiloxane bactericide, and preparation method and application thereof
  • Halamine-pyridine salt double-function group polysiloxane bactericide, and preparation method and application thereof
  • Halamine-pyridine salt double-function group polysiloxane bactericide, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Add 60 parts of R 1 =CH 3 , R 3 =H perhydrogen silicone oil, 0.005 parts of chloroplatinic acid, 300 parts of toluene, and 153 parts of tert-butyl acrylate. The system uses dry nitrogen to remove water and air, reacts at 110°C for 20 to 24 hours, then distills off toluene under reduced pressure, adds 140 parts of trifluoroacetic acid, and conducts hydrolysis reaction at 20°C for 1 to 1.2 hours to dissolve lipid bonds. Hydrolyzed to carboxyl. Then add 118 parts of 4-aminopyridine to the resulting carboxyl-containing silicone oil, use toluene as a solvent, and add 0.01 part of 2-chloro-4,6-dimethoxy-1,3,5-triazine as a catalyst. After 8-9 hours of reaction, the carboxyl group in the silicone oil reacts with the amino group in the 4-aminopyridine to form an amide bond. Then, 200 parts of 1-bromo-n-hexane was added dropwise at room temperature, and reacted for 20 to 24 hours, after which the solvent and unreacted 1-bromo-n-hexane were distilled off under reduced pressur...

Embodiment 2

[0065] Add 25 parts of R 1 =CH 2 CH 3 , R 3 =H hydrogen silicone oil, 0.003 parts of chloroplatinic acid, 100 parts of toluene, and 65 parts of tert-butyl acrylate. The system uses dry nitrogen to remove water and air, reacts at 110° C. for 24 hours, then distills off toluene under reduced pressure, adds 60 parts of trifluoroacetic acid and carries out hydrolysis reaction at room temperature for 1 hour, and hydrolyzes lipid bonds into carboxyl groups. Then add 50 parts of toluene, 50 parts of 4-aminopyridine and 0.02 parts of dicyclohexylcarbodiimide to the three-necked flask, and raise the temperature to 60°C to react the carboxyl group with the amino group to form an amide bond. Then, 180 parts of 1-chloro-n-decane were added with a dropping funnel at room temperature and reacted for 24 hours, after which the toluene solvent and unreacted 1-chloro-n-decane were distilled off under reduced pressure. Finally, 100 parts of n-propanol and 100 parts of tert-butyl hypochlorite...

Embodiment 3

[0067] Add 50 parts of R 1 =CH 2 CH 3 , R 3 =C(CH 3 ) 3 Hydrogen-containing silicone oil, 0.01 parts of methyl vinyl siloxane coordination platinum, 150 parts of toluene, and 120 parts of methyl acrylate. The system used dry nitrogen to remove water and air, reacted at 100°C for 24 hours, then distilled off toluene under reduced pressure, added 125 parts of trifluoroacetic acid and carried out hydrolysis reaction at room temperature for 6 hours, and hydrolyzed the lipid bonds into carboxyl groups. Then add 100 parts of 4-aminopyridine, 80 parts of toluene and 0.03 parts of 2-chloro-4,6-dimethoxy-1,3,5-triazine to the resulting carboxyl-containing silicone oil, and react at 30°C for 8 hours , the carboxyl group in silicone oil reacts with the amino group in 4-aminopyridine to form an amide bond. Then, 200 parts of 1-bromo-n-hexane was added dropwise at room temperature, and reacted for 24 hours, after which the solvent and unreacted 1-bromo-n-hexane were distilled off und...

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Abstract

The invention relates to a polysiloxane bactericide simultaneously carrying double halamine and pyridine salt function groups. The bactericide has a structure as shown in a general formula (I). The invention further relates to a preparation method for the bactericide. The preparation method comprises the following steps: with hydrogen-containing silicone oil as a reactant, bonding the hydrogen-containing silicone oil with an ester bond and hydrolyzing the ester bond into a carboxyl group; reacting the carboxyl group with a pyridine derivative containing an amino group so as to produce an amide bond; subjecting a pyridine ring to quaternary ammonium salinization with a halogenated compound so as to produce a pyridine salt; and halogenating the amide bond so as to produce a halamine bond. The polysiloxane bactericide provided by the invention has the advantages of high bactericidal efficiency, low toxicity, high selectivity, lasting bactericidal performance and capacity of firmly bonding with a substrate via a plurality of manners.

Description

technical field [0001] The invention belongs to the field of polymer synthesis, and in particular relates to a polysiloxane fungicide carrying a difunctional group of haloamine pyridinium salt, its preparation method and application. Background technique [0002] Pathogenic microorganisms represented by germs are very easy to survive and reproduce on various surfaces, seriously threatening human health and life. Concentrated deaths of newborns in hospitals, disease-ridden soldiers in the field, and outbreaks of epidemics in disaster-stricken areas are all disasters caused by germ infection. Maintaining daily cleanliness and sanitation is a daily problem faced by human beings. To fundamentally solve the harm of germs, the most effective and direct countermeasure is to synthesize high-efficiency broad-spectrum fungicides and use them to produce equipment and products with bactericidal capabilities. Research in this area not only has great social and economic benefits, but als...

Claims

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Application Information

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IPC IPC(8): A01N55/10A01P1/00D06M15/643C08G77/388
Inventor 陈勇李汝婷韩秋霞
Owner SHANDONG UNIV OF SCI & TECH
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