Composition and aerosol containing the composition

An aerosol and composition technology, applied in the field of aerosol, can solve the problems of increased difficulty and difficulty in the development of mixed-selection aerosol, and achieve stable quality, good suspension effect and ejection rate, and broad market prospects Effect

Active Publication Date: 2018-11-27
SICHUAN ACAD OF CHINESE MEDICINE SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The limitation of the application of this auxiliary material has brought great difficulties for the development of the mixed aerosol of the HFC system.
Furthermore, from the perspective of liquid density, HFC-134a (1.29g / mL, 20°C) is also lower than CFC (1.33g / mL, 20°C). The difficulty of type aerosol is also greatly increased

Method used

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  • Composition and aerosol containing the composition
  • Composition and aerosol containing the composition
  • Composition and aerosol containing the composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation of embodiment 1 aerosol of the present invention

[0033] (1) Preparation of Huangshi powder superfine powder:

[0034] Weigh the raw materials according to the following recipes:

[0035] Rhubarb 10kg, Coptidis 10kg, Phellodendron 10kg, Dracaena 5kg, calamine 25kg, calcined gypsum 25kg, alum 2.5kg, pig gall powder 1kg.

[0036] Preparation:

[0037] a. Take rhubarb, coptis, Phellodendron cortex, pulverize, pass through a 10-mesh sieve, add 85% (v / v) ethanol for reflux extraction, filter, and concentrate the filtrate to an extract with a relative density of 1.10 (40° C.);

[0038] b. Mix and pulverize dragon's blood, calamine, calcined gypsum, alum, and pig gall powder through a 100-mesh sieve;

[0039] c. Add the extract from step a to the mixed and pulverized powder in step b, mix well, and vacuum-dry at 60°C to make the moisture content less than 9%. The obtained dry matter is subjected to ultrafine pulverization to obtain Huangshi powder ultrafin...

Embodiment 2

[0044] Embodiment 2 Preparation of aerosol of the present invention

[0045] Raw materials were weighed according to the following recipes: pearl 6kg, bezoar 3kg, elephant skin 9kg, amber 9kg, keel 9kg, light powder 9kg, borneol 1.8kg, calamine 18kg.

[0046] Preparation method: take the above-mentioned raw material medicine and carry out ultrafine pulverization, take 5kg portion of superfine powder of raw material medicine and add it to 12kg isopropyl myristate, then add 1kg fumed silicon dioxide, grind and mix evenly through a colloid mill to form a uniform paste mixture, Fill it into an aerosol can, fill it with propellant HFC-134a, shake it, and get 1000 cans of aerosol.

[0047] The beneficial effects of the present invention are demonstrated through specific experiments below.

experiment example 1

[0048] The screening test of experimental example 1 aerosol surfactant of the present invention

[0049] (1) Experimental method:

[0050] Because it is difficult to quantitatively measure the solubility of surfactants in a high-pressure closed system, this experiment uses the visual observation method to qualitatively investigate the solubility of each surfactant in HFC-134a. Surfactants and HFC-134a are divided into obvious Two phases are recorded as immiscible. Add a small amount of 1 g of the substance to be tested into the high-pressure test tube used for the test, then fill it with 10 g of HFC-134a, shake it, ultrasonicate for 30 s, let it stand still, and observe the solubility of the substance to be tested. Solubility studies were carried out in the following types of surfactants: Brijis (polyoxyethylene ethers), Tween (polyoxyethylene sorbitan fatty acid esters), Span (sorbitan fatty acid esters), fatty acid esters, vegetable oils kind.

[0051] (2) The experimental ...

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Abstract

The invention provides a composition and its application, which comprises the following components in weight ratio: 10-100 parts of HFC-134a, 5-50 parts of isopropyl myristate, 0.1-10 parts of fumed silicon dioxide . The present invention also provides an aerosol and its preparation method and use, which includes the following raw and auxiliary materials in the following weight ratio: 5-20 parts of bulk drug, 10-100 parts of HFC-134a, 5-100 parts of isopropyl myristate 50 parts, fumed silica 0.1-10 parts. The invention also provides the use of the aerosol in the preparation of medicines for treating burns, bedsores and skin ulcers caused by diabetes. The aerosol prepared by the invention has good suspending effect and ejection rate, stable quality, convenient and rapid administration, and has broad market prospect.

Description

technical field [0001] The invention relates to a composition and an aerosol containing the composition, belonging to the field of medicine. Background technique [0002] Aerosol is a small dosage form in pharmacy, but it has played a unique effect in real life and drug application practice, and is generally welcomed. However, in the current practical application, the development of aerosols is facing the most urgent and difficult problem, that is, the dilemma of replacing the propellant Freon. [0003] CFC (Chlorofluorocarbon), also known as chlorofluoroalkane or freon, has been widely used in the field of pharmaceutical aerosols for more than half a century due to its unique properties and good propulsion driving performance. However, the destruction of the atmospheric ozone layer by CFCs is one of the major environmental problems faced by human beings. The Montreal Protocol signed in 1987 proposed a ban schedule for five CFCs (11, 12, 113, 114, 115): developed countries...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/12A61K47/06A61K47/14A61K47/04A61K33/30A61K33/06A61K35/618A61K36/896A61P17/02A61P3/10A61K35/413A61K35/36A61K35/02A61K35/10A61K31/045
Inventor 朱宁周在富华桦文筱
Owner SICHUAN ACAD OF CHINESE MEDICINE SCI
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