Compound long-acting injection containing enrofloxacin and meloxicam, and preparation method of compound long-acting injection

A technology of meloxicam and injection, which is applied in the field of compound long-acting injection and its preparation, can solve the problems of inconvenient clinical application, unfavorable drug efficacy, and excessive drinking water waste, so as to enhance animal compliance and reduce animal stress. Exciting and cost-saving effects
CN110327348AInactive Publication Date: 2019-10-15余祖功
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
余祖功
Publication Date
2019-10-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention discloses a compound long-acting injection containing enrofloxacin and meloxicam. The compound long-acting injection comprises the enrofloxacin and / or a salt thereof, the meloxicam in a dispersion form, a meloxicam solid dispersoid, a high molecular retardant, a wetting agent and a dispersion medium; each 1,000 mL of the injection contains 20-250 g of the enrofloxacin and / orthe salt thereof (calculated by the enrofloxacin), 5-50 g of the meloxicam in the dispersion form, 5-30 g of the high molecular retardant, 5-20 g of the wetting agent, and the balance of a dispersionmedium; and a mass ratio of the meloxicam in the dispersion form to the meloxicam solid dispersoid (calculated by the meloxicam) is (5:1)-(1:1). The injection preparation is stable in quality, slow indrug release, safe and effective, only 1-2 times of drug administration in one course of treatment can treat both symptoms and root causes, and effective blood drug concentration is maintained for 3-7 days; and only 1 needle is used for injection for 1 time, so that the compound long-acting injection enhances animal compliance, reduces animal stress and is more favorable for disease outcome and prognosis.
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Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations for animals, and relates to a compound long-acting injection containing enrofloxacin and meloxicam and a preparation method thereof. Background technique

[0002] Enrofloxacin is also known as ethyl ciprofloxacin and enrofloxacin. It has a wide antibacterial spectrum and strong bactericidal power. It has a strong effect on Gram-positive bacteria, negative bacteria, mycoplasma, and some anaerobic bacteria, especially on Gram-negative bacilli. Sensitive bacteria include Staphylococcus aureus Coccus, Streptococcus, Actinomyces pyogenes, Escherichia coli, Salmonella, Pasteurella, Klebsiella, Proteus, Pseudomonas aeruginosa, Haemophilus, Bordetella, Erysipelas; have special effects on mycoplasma, It is more effective than tylosin and colistin, and it is still effective against both drug-resistant mycoplasma, especially against mycoplasma gallisepticum; it also has a certain effect on mycobac...

Claims

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