Polyethylene glycol/chitosan microsphere composite biological medical dressing

A chitosan microsphere, biomedical technology, applied in medical science, bandages, absorbent pads, etc., can solve problems such as wound infection and suppuration, wound adhesion, new tissue damage, etc., achieve fast healing time, relieve pain, and operate simple effect

Inactive Publication Date: 2015-11-11
JIANGSU JINYU ENVIRONMENTAL ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, traditional methods rely on chemical drugs or antibiotics to achieve antibacterial and bactericidal purposes, so it is difficult to avoid adverse irritation and drug-resistant strains to human skin. At the same time, the most commonly used clinical dressing is gauze. This inert dressing , although it has the advantages of good absorption, wound protection,

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0018] First in parts by weight, choosing 35 parts of chitosan powder, 20 parts of mass fraction as 36% acetic acid solution, 30 parts of liquid paraffin and 15 parts of sorbitan fatty acid esters mixed to form an emulsifier, Mix and stir at 30°C for 30min, and the mixing speed is 1200r / min, so that the chitosan solution is uniformly dispersed to form an emulsion for standby; then, according to the total mass of 100g, select 50g of the chitosan liquid forming the emulsion and 30g of ethylene glycol Alcohol and 20g of 0.8mol / L NaOH solution, carry out cross-linking reaction under alkaline conditions, and raise the temperature to 60°C for 3h; It was subjected to suction filtration, and the filter cake was extracted with petroleum ether and acetone in a Soxhlet extractor for 24 hours, and the filter cake was taken out and vacuum-dried at 50°C for 30 minutes to prepare a blank chitosan microsphere carrier Standby; weigh 10g of polyethylene glycol, dissolve it in 100mL of boiling w...

example 2

[0020] First in parts by weight, choosing 5 parts of chitosan powder, 40 parts of mass fraction is 36% acetic acid solution, 30 parts of liquid paraffin and 25 parts of sorbitan fatty acid esters mixed to form an emulsifier. Mix and stir for 30min at 30°C, and the mixing speed is 1000r / min, so that the chitosan solution is uniformly dispersed to form an emulsion for standby; then, according to the total mass of 200g, select 40g of the emulsion-formed chitosan liquid and 100g of ethylene glycol Alcohol and 60g of 0.8mol / L NaOH solution, carry out the cross-linking reaction under alkaline conditions, and raise the temperature to 60°C for 2h; It was subjected to suction filtration, and the filter cake was extracted with petroleum ether and acetone in a Soxhlet extractor for 20 hours, and then the filter cake was taken out and vacuum-dried at 50°C for 20 minutes to obtain a blank chitosan microsphere carrier Standby; weigh 10g of polyethylene glycol, dissolve it in 100mL of boilin...

example 3

[0022] First by weight parts, choose 30 parts of chitosan powders, 25 parts of mass fractions are 36% acetic acid solution, 30 parts of liquid paraffin and 15 parts of sorbitan fatty acid esters mixed to form emulsifier, in Mix and stir at 30°C for 30min, and the mixing and stirring speed is 1100r / min, so that the chitosan solution is uniformly dispersed and formed into an emulsion for subsequent use; then, according to a total mass of 300g, select 75% of the chitosan liquid that forms an emulsion, and 135% of the chitosan liquid that forms an emulsion. Ethylene glycol and 90g of 0.8mol / L NaOH solution were cross-linked under alkaline conditions, and the temperature was raised to 60°C for 2 hours; after the cross-linking was completed, it was washed with a large amount of deionized water until the pH was 7. And carry out suction filtration on it, extract its filter cake with petroleum ether and acetone respectively in Soxhlet extractor for 22 hours, take out the filter cake and...

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PUM

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Abstract

The invention relates to a polyethylene glycol/chitosan microsphere composite biological medical dressing and belongs to the field of medical dressings. The method includes the steps that firstly, chitosan powder and an acetic acid solution are selected, mixed and stirred to be in an emulsion state; the mixture in the emulsion state has a cross-linking reaction with ethylene glycol and a NaOH solution, reactants are washed to be neutral with deionized water, and blank chitosan microsphere carriers are obtained after suction filtration, suction extraction and drying; polyethylene glycol is dissolved in boiled water and stirred, dibenzyl isopropyl phenyl phenol emulgators and the like are added after the temperature is lowered, chitosan microspheres are added after the dibenzyl isopropyl phenyl phenol emulgators are evenly mixed and dissolved; then hydrochloric acid is added, and after being completely foamed, a mixed solution is injected into a polyethylene mold; an obtained product is taken out and repeatedly washed with distilled water, and the polyethylene glycol/chitosan microsphere composite biological medical dressing can be obtained through drying. The polyethylene glycol/chitosan microsphere composite biological medical dressing has the advantages that the healing time of a wound is short, the dressing does not adhere to the wound, and the pain of a patient is relieved; the dressing is easy to operate and low in needed cost.

Description

technical field [0001] The invention relates to a polyethylene glycol / chitosan microsphere composite biomedical dressing, which belongs to the field of medical dressings. Background technique [0002] There are a large number of patients with skin defects in our country and the whole country every year, mainly due to safety accidents, burn patients and patients with large-scale skin ulcers caused by diseases, the development of chemical industry and current industry, modern weapons and frequent wars, the number of burn patients is increasing every year. With the rapid increase of the aging population and the deterioration of the environment, the number of people with large areas of skin ulcers caused by diseases such as diabetes has increased. Therefore, the demand for biological dressings is increasing day by day. [0003] At present, traditional methods rely on chemical drugs or antibiotics to achieve antibacterial and bactericidal purposes, so it is difficult to avoid ad...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/26A61L15/42
Inventor 李锦宇薛红娟高力群
Owner JIANGSU JINYU ENVIRONMENTAL ENG
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