A Folic Acid Modified Realgar-Mesoporous Silica Nanocomposite Drug

A technology of mesoporous silica and folic acid, applied in the directions of nano-drugs, drug combinations, nano-technology, etc., can solve the problems of normal cytotoxicity and side effects, and achieve the effects of easy modification, high yield and simple synthesis process
CN105079814BInactive Publication Date: 2018-07-24CHINA PHARM UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHINA PHARM UNIV
Publication Date
2018-07-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

Aiming at the defect that nano-realgar also has certain toxic and side effects on normal cells, the present invention modifies folic acid on the surface of mesoporous silica nanoparticles, and then loads realgar, aiming at improving its active targeting in vivo, and specifically relates to a folic acid-modified Realgar-mesoporous silicon oxide nanocomposite drug and preparation method thereof. In the present invention, by investigating the volume ratio of ethylenediamine to water, the concentration of realgar ethylenediamine solution, the carrier amount and the loading time, it is found that the folic acid-modified mesoporous silica nanoparticles have a certain loading capacity for realgar, forming a folic acid-modified Realgar-mesoporous silica nanocomposite drugs, and its morphology and structure have not changed significantly, but its targeting properties need to be further verified by in vitro cell experiments.
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Description

technical field

[0001] The patent of the present invention relates to the technical field of preparation of mesoporous materials and pharmaceutical preparations, in particular to a folic acid-modified realgar-mesoporous silica nanocomposite drug and a preparation method thereof. Background technique

[0002] Realgar, a mineral medicine, is a traditional Chinese medicine with a long history of application in traditional Chinese medicine. It was first recorded in "Shen Nong's Materia Medica". 4 S 4 ), and mixed with a small amount of arsenic (As 2 o 3 ) and other heavy metal salts, used for detoxification, insecticide, dampness, phlegm, malaria, etc. Since the 1950s, many domestic scholars have used realgar-containing compound preparations or single realgar for clinical treatment of tumors in the blood system and other parts of the human body, and achieved good curative effects. And because its toxicity is lower than arsenic injection, realgar is recommended as a second-li...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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