Compound capsule containing aspirin and proton pump inhibitor
A technology of proton pump inhibitors and aspirin, which is applied in the field of compound capsules containing aspirin and proton pump inhibitors, can solve the problems of instability of proton pump inhibitors, loss of protection of proton pump inhibitors in gastrointestinal mucosa, and short half-life, etc. Achieve the effect of being conducive to industrialized large-scale production, convenient for quality control, and simple process
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[0068] The preparation method of the compound capsule containing aspirin and proton pump inhibitor of the present invention includes the following steps:
[0069] The first part: Mix aspirin, stabilizer, porogen and framework material according to the prescription ratio, add appropriate amount of binder to prepare soft material, extrude it through extruder, and place the bar in the spheronizer to spheronize. The rounded pellets are heat-treated and dried, and then sieved for use. The HPMC solution is prepared and the anti-sticking agent and the sunscreen are added according to the prescription ratio to prepare the isolation layer coating liquid, and the prepared aspirin pill core is placed in a fluidized bed to coat the isolation coating. Prepare the enteric coating liquid according to the prescription ratio and wrap it outside the isolation coating.
[0070] The second part: Mix the prescribed amount of proton pump inhibitor, stabilizer and filler uniformly, prepare proton pump i...
Example Embodiment
[0074] Example 1
[0075] first part
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[0078] the second part
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[0080] the third part
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[0082] Preparation:
[0083] ① Mix aspirin, tartaric acid, lactose, stearic acid and ethyl cellulose according to the prescription ratio, add 10% starch slurry to prepare soft material, extrude it through an extruder, and place the strips in a spheronizer to round. The rounded pellets are dried in an oven and sieved for use. Prepare HPMC solution (100 mL) and add talc powder and titanium dioxide according to the prescription ratio to prepare isolation layer coating liquid, and place the prepared aspirin-containing pill core in a fluidized bed to coat the isolation coating. The enteric coating solution (50 mL) was prepared according to the prescription ratio and wrapped outside the isolation coating.
[0084] ②Mix the prescription amount of pantoprazole, sodium bicarbonate, and sucrose evenly, and prepare pantoprazole drug-loaded pellets with hydroxypropylmethyl c...
Example Embodiment
[0087] Example 2
[0088] first part
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[0090]
[0091] the second part
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[0093] the third part
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[0096] The preparation methods ①, ②, and ③ are the same as in Example 1.
[0097] Preparation method ④: Weigh about 700 mg of the first part, about 40 mg of the second part, and about 150 mg of the third part, and fill them in a gelatin capsule shell after uniformly mixing to prepare a compound capsule containing aspirin and esomeprazole.
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