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Dental implant coated with mixture solution of ph buffer material and organic amphiphilic material having sulfonic group and method for preparing same

A technology of amphiphilic substances and buffer substances, applied in dentistry, prostheses, coatings, etc., can solve problems such as hindering comprehensive treatment or implantation process, water retention at the level of 3 months, and extended period of stable implants. Achieve the effect of improving implant biocompatibility and body fluid and blood affinity, improving body fluid and blood affinity, and excellent biocompatibility

Active Publication Date: 2015-12-09
(株)奥齿泰种植体
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, in the case of surface treatment methods such as RBM or SLA, which are widely used at present, when the product is exposed to the air after the surface treatment process, an oxide layer grows on the surface of the product, and hydrocarbons Adsorption of various pollution sources such as the
Since the surface thus hydrophobized has low wettability to body fluids and blood, there are disadvantages such as hindering the overall treatment or implantation process of fusion with the bone after the implant is placed, and prolonging the period of stabilizing the implant.
Using said known prior art can carry out superhydrophilization to titanium surface in a short period of time, but there are still problems in maintaining said superhydrophilicity for a long time, Suzuki (Suzuki) etc. propose to use 4- (2-Hydroxyethyl)-1-piperazineethanesulfonic acid (4-(2-Hydroxylethyl)-1-piperazineethanesulfonic acid) is an example of hydrophilization of titanium surfaces, but it can only maintain the hydrophilicity at 3 month level

Method used

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  • Dental implant coated with mixture solution of ph buffer material and organic amphiphilic material having sulfonic group and method for preparing same
  • Dental implant coated with mixture solution of ph buffer material and organic amphiphilic material having sulfonic group and method for preparing same
  • Dental implant coated with mixture solution of ph buffer material and organic amphiphilic material having sulfonic group and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] 【Example 1】 Coating of pH buffer substance and organic amphiphile (1M)

[0048] Use Al with a particle size of 1 mm or less 2 o 3After blasting the machined titanium implant with a blast pressure of 1 to 10 air pressure for 1 to 60 seconds, macroscopic and Micro-morphology (macro-µ-morphology). Dental titanium implants thus acid-treated were ultrasonically cleaned for 30 minutes using ethanol and distilled water respectively, followed by a drying step.

[0049] The surface of the implant after the drying step is treated with plasma (plasma) or ultraviolet light for 5 minutes to remove the pollution source adsorbed and stabilized on the surface, and the surface of the implant is uniformly coated with a pH buffer substance, and Excluded organic amphiphilic substances with sulfo groups (BES, HEPES, TES) 1M aqueous solution (refer to figure 1 ), the mixed solution of the organic amphiphilic substance and the pH buffer substance is range coated on the implant surfa...

Embodiment 2

[0052] [Example 2] Measuring the Bone Interface Bonding Force of Dental Implants Depending on the Presence or Absence of pH Buffering Substances

[0053] The bone interface bonding force of the coated dental implant was subjected to accelerated aging ( accelerationaqging, hereinafter referred to as 'AA') for measurement. The BES, HEPES, and TES-coated dental implants produced in [Example 1] were placed under accelerated aging conditions (about 55°C) for 18 weeks (equivalent to 3 years of normal storage, accelerated aging for 18 weeks) (accelerationaqging18weeks), marked as 'AA18W', defined in the same manner as this below), in order to confirm the implant-bone interface bonding force, the implant was implanted in the mandible of the miniature pig (micropig), and at 16 After the bone formation period, removal torque was measured. At this time, as a negative control group, implants without decontamination (SA) were used, and as a positive control group, implants (SA+ PT), t...

Embodiment 3

[0056] [Example 3] Coating a titanium disc surface with a mixed solution of a pH buffer substance and an organic amphiphilic substance with a sulfo group noodle

[0057] After the pollution source is removed on the surface of the titanium disk, a coating layer is formed by using a mixed solution of a pH buffer substance and an organic amphiphilic substance with a sulfo group.

[0058] Use Al with a particle size of 1 mm or less 2 o 3 After the powder is sprayed on the machined titanium disc with a blast pressure of 1-10 atmospheres for 1-60 seconds, macroscopic and microscopic morphology can be formed on the surface of the implant by acid treatment using a mixed acid aqueous solution. The acid-etched dental titanium disc was ultrasonically cleaned for 30 minutes with ethanol and distilled water, respectively, and then dried.

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Abstract

The present invention relates to a dental implant of titanium or a titanium alloy, and, more specifically, to a bioactive type hydrophilic dental implant characterized in that, for removal of contaminants, a pretreated surface is coated with a mixture solution containing: i) an organic pH buffer material and / or an inorganic pH buffer material; and ii) an organic amphiphilic material having a sulfonic group. The dental implant having a surface, from which organic contaminants have been removed, is surface-coated with the mixture solution containing the pH buffer material and the organic amphiphilic material having a sulfonic group (BES, HEPES, MOPS, PIPES, or TES), thereby preventing the surface of the dental implant from being changed into being hydrophobic, which is caused by the exposure of the dental implant to air and thus the recontamination of the dental implant by organic contaminants before the dental implant is implanted in the alveolar bone, and preventing a deterioration in bioactivity due to the hydrophobicity of the surface due to the surface hydrophobicity , so that the dental implant can improve biocompatibility, affinity to the body fluid and blood, and initial osseointegration thereof. Further, the organic pH buffer material and the organic amphiphilic material are coated on the surface of the implant, thereby effectively preventing the adsorption of contaminants in the air on the surface of the implant; the coating layer uniformly coated on the surface exhibits biocompatibility and affinity to the body fluid and blood, thereby enhancing the initial osseointegration after implantation and finally shortening the osseointegration period; and the mixture solution of the pH buffer material and the organic amphiphilic material having a sulfonic group is used as a surface coating solution, thereby maintaining the surface of the dental implant to be hydrophilic for at least three years.

Description

technical field [0001] The present invention provides a dental implant coated with a mixed solution comprising an organic or inorganic pH buffering agent (pH buffering substance) and an organic amphiphilic compound and a manufacturing method thereof, which is used for improving titanium or titanium with a rough surface. The existing RBM (ResorbableBlastedMediablasting) and SLA (SandblastLargegritAcidetch) surface treatment methods in which the alloy implant surface is polluted by organic pollution sources maintain the surface of the implant for a long time. Super hydrophilic. Thus, a dental metal implant can be provided, which can enhance the biological activity of the surface of RBM or SLA, improve the compatibility of body fluid and blood, and finally be used in implantation for a long time of more than 3 years. After body surgery, it has excellent biocompatibility, bone formation effect and short osseointegration period, and its biological activity is improved. Backgroun...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61C8/00A61L27/28A61L27/06
CPCA61C8/0013A61L27/06A61L27/14A61L27/28A61L2430/12A61C8/00A61C8/0015
Inventor 金秀曔张一锡宋住东严泰官崔圭钰
Owner (株)奥齿泰种植体