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Method for extracting hesperidin from pericarpium citri reticulatae

A technology of hesperidin and tangerine peel, which is applied in the field of extracting hesperidin from tangerine peel, can solve the problems of long time, easy to destroy active ingredients, and low extraction efficiency, and achieve the goals of accelerating dissolution speed, accelerating mass transfer, and improving extraction efficiency Effect

Active Publication Date: 2015-12-23
广东橘香斋大健康产业股份有限公司
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional methods of extracting hesperidin from tangerine peel mainly include water extraction, alcohol reflux method and alkali extraction and alcohol precipitation method. Although these methods are simple to operate, the extraction efficiency is low and it is easy to cause environmental pollution.
In recent years, it has been reported that microwave method and ultrasonic method are used to extract hesperidin in tangerine peel, the extraction efficiency is higher, and the extraction time is also shorter, but the noise of ultrasonic method is very large, microwave method has radiation, and the price of microwave equipment is relatively expensive. To a certain extent, it limits its application in large-scale production of enterprises
[0003] In the prior art, the literature (research on the extraction and purification process of hesperidin in tangerine peel, Qi Bing, food industry science and technology, the 24th phase of the 33rd volume, the 343-346 page, 2012) records a kind of extracting from tangerine peel The technical scheme of hesperidin is to crush and dry dried tangerine peel, put the tangerine peel into a flask, add a certain concentration of ethanol solution according to a certain ratio of material to liquid, place it in a constant temperature water bath, and cool the extract to room temperature after reflux extraction for a period of time, and filter , to obtain, the ratio of solid to liquid is orange peel: ethanol solution=1g: (25,30,35) mL; ethanol solution volume concentration is 75%, 80%, 85%; extraction time is 2.5h, 3h, 3.5h; extraction The temperature is 75°C, 80°C, and 85°C, and the extraction yield is 2.16-3.33%. This extraction method takes a long time, easily destroys the active ingredients, and the extraction yield is low

Method used

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  • Method for extracting hesperidin from pericarpium citri reticulatae
  • Method for extracting hesperidin from pericarpium citri reticulatae

Examples

Experimental program
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Effect test

Embodiment 1

[0025] The method that present embodiment extracts hesperidin from tangerine peel, comprises the following steps:

[0026] 1) Dried tangerine peel at 50° C. for 4 hours, and crushed to 100 mesh to obtain tangerine peel powder;

[0027] 2) Take tangerine peel powder, add ethanol solution with a volume concentration of 50%, add 40mL ethanol solution for every 1g of tangerine peel powder, to obtain a mixture;

[0028] 3) Put the mixture in step 2) into a polytetrafluoroethylene-lined stainless steel reaction kettle, then put it into an oven with a temperature of 120°C, extract for 45 minutes, cool to room temperature, and then centrifuge at a high speed of 10000r / min 5min to obtain hesperidin extract.

[0029] Take the hesperidin extract, dilute it 100 times with a methanol solution with a volume concentration of 50%, and measure the yield of hesperidin by high performance liquid chromatography. The chromatographic conditions are chromatographic column: KromasilC18, specificatio...

Embodiment 2

[0032] The method that present embodiment extracts hesperidin from tangerine peel, comprises the following steps:

[0033] 1) Dried tangerine peel at 60° C. for 3 hours, and crushed to 80 mesh to obtain tangerine peel powder;

[0034] 2) Take tangerine peel powder, add ethanol solution with a volume concentration of 60%, add 70mL ethanol solution for every 1g of tangerine peel powder, to obtain a mixture;

[0035] 3) Put the mixture in step 2) in a polytetrafluoroethylene-lined stainless steel reaction kettle, then put it into an oven with a temperature of 120°C, extract for 15 minutes, cool to room temperature, and centrifuge at a high speed of 10,000r / min 5min to obtain hesperidin extract.

[0036] The yield of hesperidin was determined by high performance liquid chromatography, and the assay method was the same as in Example 1, and the yield of hesperidin was 4.38%.

Embodiment 3

[0038] The method that present embodiment extracts hesperidin from tangerine peel, comprises the following steps:

[0039] 1) Dried tangerine peel at 60° C. for 3 hours, and crushed to 100 mesh to obtain tangerine peel powder;

[0040] 2) Take tangerine peel powder, add ethanol solution with a volume concentration of 50%, add 50mL ethanol solution for every 1g of tangerine peel powder, to obtain a mixture;

[0041] 3) Put the mixture in step 2) into a polytetrafluoroethylene-lined stainless steel reaction kettle, then put it into an oven with a temperature of 135°C, extract for 45min, cool to room temperature, and then centrifuge at a high speed of 10000r / min 5min to obtain hesperidin extract.

[0042] The yield of hesperidin was determined by high performance liquid chromatography, and the assay method was the same as in Example 1, and the yield of hesperidin was 4.62%.

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Abstract

The invention discloses a method for extracting hesperidin from pericarpium citri reticulatae, which belongs to the technical field of hesperidin extraction. The method comprises the following steps: taking pericarpium citri reticulatae powder, and adding an ethanol solution, so that a mixture is obtained, wherein 40-90 ml of ethanol solution is added into 1 g of pericarpium citri reticulatae powder; and putting the mixture into an airtight container, carrying out extraction for 15-75 min at a temperature of 90-135 DEG C, cooling to room temperature, taking out liquid supernatant, and carrying out centrifugal separation on the liquid supernatant, so that a hesperidin extracting solution is obtained. Hesperidin is extracted from pericarpium citri reticulatae by using an ethanol solution, so that the extraction yield is high, and up to 6.1%. The method for extracting hesperidin from pericarpium citri reticulatae has the advantages of cheap and easily-obtained equipment, simplicity in operation, rapidness, high extraction yield, and the like, and is conducive to mass production.

Description

technical field [0001] The invention belongs to the technical field of hesperidin extraction, in particular to a method for extracting hesperidin from tangerine peel. Background technique [0002] Tangerine peel is the dry and mature peel of Rutaceae plant orange and its cultivars. It is rich in pigments, essential oils and flavonoids and other active ingredients. Hesperidin is one of the main active ingredients of tangerine peel. The pure product is white needle-like crystals with the molecular formula C 28 h 34 o 15 . Studies have shown that hesperidin has physiological functions such as anti-oxidation, anti-allergy, antibacterial and anti-inflammatory, anti-virus and anti-cancer, prevention of cardiovascular diseases, lowering blood pressure, lowering low-density cholesterol, etc., and has high medicinal value. In addition, hesperidin is also used in the food and cosmetic industries as a natural oxidizing agent. The traditional methods for extracting hesperidin from ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08
Inventor 李杰逄显娟和素娜杨晖王学亭陈克莉陈道鸽
Owner 广东橘香斋大健康产业股份有限公司
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