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Theaflavin-containing pharmaceutical composition and application thereof in the aspect of lowering blood fat

A technology of theaflavin and composition, which is applied in the application field of treating hyperlipidemia and related diseases, can solve the problems of inconvenient quality control, drug efficacy, and inconvenient adverse reaction monitoring, so as to improve gastrointestinal microcirculation function, reduce Effect of drug oxidation failure and easy quality control

Inactive Publication Date: 2016-01-20
成都普瑞法科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are some blood lipid-lowering traditional Chinese medicines on the market, and most of them use effective parts of traditional Chinese medicines, compound extracts, and single medicinal material extracts as active ingredients, which is not convenient for quality control and drug efficacy, and it is not convenient for adverse reaction monitoring.

Method used

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  • Theaflavin-containing pharmaceutical composition and application thereof in the aspect of lowering blood fat
  • Theaflavin-containing pharmaceutical composition and application thereof in the aspect of lowering blood fat
  • Theaflavin-containing pharmaceutical composition and application thereof in the aspect of lowering blood fat

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Weigh 6 g of EPA, 9.75 g of theaflavin (TF) and 10 g of commercially available microcrystalline cellulose, and pass through a 60-mesh sieve after mixing. Spray 6ml of 95% ethanol into the resulting mixture, stir and mix evenly and pass through a 30-mesh sieve again to obtain small particles, dry at 55°C for 1.5 hours and pack into No. 1 capsules to make hard capsules.

Embodiment 2

[0030] Weigh 7.5g of DHA, 8.5g of theaflavin (TF) and 2.5g of theaflavin (TF-3-G) respectively, add 15g of corn starch, 10g of microcrystalline cellulose, povidone K 30 3g, 7g of sodium carboxymethyl starch were mixed and passed through an 80-mesh sieve. Add 10ml of 95% ethanol to the resulting mixture, stir and mix evenly, pass through a 30-mesh sieve to prepare wet granules, then dry in an oven at 45°C for 1.5 hours, and turn the granules once every 30 minutes. After the dried granules are passed through a 20-mesh sieve for granulation, an appropriate amount of magnesium stearate is added, mixed evenly, and compressed to prepare tablets.

Embodiment 3

[0032] Weigh 7.5g of DHA, 3.5g of theaflavin (TF-3-G) and 4.5g of theaflavin (TFDG) respectively, add 10g of corn starch, 15g of microcrystalline cellulose, povidone K 30 3g, 7g of sodium carboxymethyl starch were mixed and passed through an 80-mesh sieve. Add 10ml of 95% ethanol to the resulting mixture, stir and mix evenly, pass through a 30-mesh sieve to prepare wet granules, then dry in an oven at 45°C for 1.5 hours, and turn the granules once every 30 minutes. After the dried granules are passed through a 20-mesh sieve for granulation, an appropriate amount of magnesium stearate is added, mixed evenly, and compressed to prepare tablets.

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Abstract

The invention relates to the field of medicinal health, and particularly relates to a pharmaceutical composition which is prepared by combination of polyunsaturated fatty acids and theaflavin and has an effect of lowering blood fat. The polyunsaturated fatty acids and theaflavin used as main effective ingredients are combined with beneficial effects of the polyunsaturated fatty acids and the theaflavin in the aspect of lowering blood fat. Tests prove that the composition can be used for remarkably reducing the blood-fat level and ambulatory arterial stiffness index of an experimental animal and effectively controlling the blood-fat level. The composition is completely prepared from natural animal and plant ingredients which are used as effective ingredients, has the advantages of wide material source, low production cost, no dependence after long-time taking, no toxic or side effect and the like, is safe and effective, and is suitable for large-scale popularization and application.

Description

technical field [0001] The invention relates to the field of medicine and health, in particular to a medicine with theaflavins and polyunsaturated fatty acids as main active ingredients and the application of the medicine composition in treating hyperlipidemia and related diseases. Background technique [0002] Hyperlipidemia is a common cardiovascular disease caused by disorders of blood lipid metabolism. Often manifested as serum total cholesterol (TC) or triglyceride (TG) levels are too high and (or) high-density lipoprotein cholesterol (HDL-C) is too low. Hyperlipidemia is a common and frequently-occurring disease among middle-aged and elderly people. With the improvement of living standards and changes in living habits and dietary structure in recent years, the number of people with hyperlipidemia continues to increase and tends to become younger. Atherosclerosis caused by hyperlipidemia is the main cause of coronary heart disease, hypertension, and cardiovascular and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/353A61P3/06A61K31/202
Inventor 谢海峰罗明锋胡云岭谢期林
Owner 成都普瑞法科技开发有限公司
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