Antioxidant composition with synergistic effect

A composition and anti-oxidation technology, applied in the direction of medical preparations containing active ingredients, cosmetics, cosmetics, etc., can solve the problems of antioxidant inactivation, unstable antioxidant components, and weak antioxidant capacity Lipid peroxidation ability, enhanced oxidative stress defense, and reduced oxidative failure effects

Active Publication Date: 2022-06-24
ZHEJIANG YIGE ENTERPRISE MANAGEMENT GRP CO LTD
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  • Summary
  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Since the neutralized free radicals with antioxidant capacity in antioxidants cannot be regenerated once they are consumed, most of the current antioxidants in the market are high in monomers content, that is, by increasing the amount of antioxidant ingredients added to ensure its antioxidant effect and stability, resulting in this antioxidant product can only eliminate free radicals from a single dimension, and other free radicals will still cause different damage to the human body , the antioxidant effect is not ideal
On the other hand, for the expensive Ve-type antioxidants, the increase in the addition of this component will cause an increase in the overall cost of the product, which cannot meet the economic benefits of the manufacturer and the needs of users; and an excessively high addition concentration will also lead to Irritation problems or other side effects, such as high-purity Vc will show strong irritation, and Ve will turn into pro-oxidant after the concentration reaches a certain level
On the other hand, the antioxidant components of the monomer itself are not stable, such as VC antioxidants, which are very easy to be oxidized and change color and taste, which makes it difficult to apply directly to cosmetics
[0004]In addition, because cosmetic substances stay on the skin surface for a long time, it will also cause excessive oxidation of sebum, causing a series of problems, which makes how to add antioxidants to cosmetics Substances have also become a problem that manufacturers need to face
Most of the existing finished antioxidants are in liquid state, making it difficult to directly combine with cosmetic substances; and for some solid antioxidants, they need to be made into powder by grinding process and added with cosmetic substances
However, this treatment process not only easily causes the inactivation of antioxidants during the grinding process, but also causes the local antioxidant concentration of makeup substances to be too high due to the problem of mixing uniformity after the addition of antioxidants, and then after application Brings safety problems and increases the difficulty of combining antioxidants and cosmetic substances
[0005] Therefore, the existing antioxidants have the problems of high addition, weak antioxidant capacity and poor stability

Method used

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  • Antioxidant composition with synergistic effect
  • Antioxidant composition with synergistic effect
  • Antioxidant composition with synergistic effect

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0029] The preparation method of the antioxidant composition comprises the following steps:

[0030] ①Add 2.5g of caprylic / capric acid triglyceride per 0.001g of dimethylmethoxychromanol, then heat to 80-85°C at a speed of 1-2°C / min to dissolve it uniform, get A grade;

[0031] ② After heating 0.8g of polyglycerol-10 laurate to 80-85°C, slowly add it to product A and mix well to obtain oil phase B;

[0032] 3. Add 4g of PEG / PPG-14 / 7 dimethyl ether to 80g of deionized water, and heat it to 70 to 80°C at a rate of 0.5 to 1°C / min to obtain c1 water phase; then slowly add B oil phase In the aqueous phase of c1, and replenishing water to 99.78g to obtain C mixture;

[0033] 4. After the C mixture was cooled to 45°C, 0.02 g of thiotaurine was added to obtain the D mixture;

[0034] ⑤ After the D mixture was continuously cooled to 38° C., 0.2 g of decarboxylated carnosine was added to make the final mass of the mixture reach 100 g to obtain a finished antioxidant composition.

[...

experiment example 1

[0043] Experimental Example 1: The antioxidative ability of the sample was tested with the quenching ability to singlet oxygen as an index.

[0044] Wherein sample 1 is 2.00% (mass concentration) decarboxylated carnosine hydrochloride, sample 2 is 0.5% thiotaurine, sample 3 is 0.05% dimethylmethoxychromanol, sample 4 is an antioxidant composition consisting of 0.2% decarboxylated carnosine hydrochloride, 0.02% thiotaurine and 0.001% dimethylmethoxychromanol. Singlet oxygen quenching ability. The test results are shown in Table 1:

[0045] Table 1 The scavenging rate of each sample to singlet oxygen quenching

[0046]

[0047] The effective concentration of decarboxylated carnosine is 0.75%, the effective concentration of thiotaurine is 0.002%, and the effective concentration of dimethylmethoxychromanol is 0.00001%. A single antioxidant at a super-effective concentration was used as a sample for comparison. As can be seen from the test results, sample 4, by the combination...

experiment example 2

[0052] Experimental Example 2: Using the ability of the sample to reduce the oxidized fatty acid (LOOH) formed by lipid peroxidation to a non-toxic fatty alcohol (LOH) as an index, the ability of the sample to scavenge lipid peroxides was tested. Among them, sample 1 is 2% decarboxylated carnosine hydrochloride, sample 2 is 0.5% thiotaurine, sample 3 is 0.05% dimethylmethoxychromanol, and sample 4 is from 0.2 Antioxidant composition consisting of % decarboxylated carnosine hydrochloride, 0.02% thiotaurine and 0.001% dimethylmethoxychromanol. The LOOH and LOH content in each sample were tested by HPLC. The test results are shown in Table 3:

[0053] Table 3 Oxidized fatty acid scavenging rate of each sample

[0054]

[0055]

[0056] According to the test results, sample 4 can effectively improve the scavenging ability of lipid peroxides compared with the other three groups of samples. By compounding the two components of thiotaurine and dimethylmethoxychromanol, the e...

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Abstract

The invention discloses an antioxidant composition with a synergistic effect. The antioxidant composition is prepared from the following components in percentage by weight: 0.2 to 1 percent of decarboxylated carnosine hydrochloride, 0.002 to 0.02 percent of thiotaurine and 0.001 to 0.01 percent of dimethyl methoxy benzodihydropyranol. According to the present invention, the toxic peroxide fatty acid can be reduced into the non-toxic fatty alcohol, the sebum oxidation and the generation of the active oxygen causing the oxidation damage to the skin surface can be inhibited, the lipid peroxidation ability can be reduced, the oxidative stress defense can be enhanced, and the characteristics of low addition amount, strong oxidation resistance and high stability can be provided.

Description

technical field [0001] The present invention relates to an antioxidant composition, especially an antioxidant composition with synergistic effect. Background technique [0002] Excessive UV exposure, air pollution and other external problems in life will continuously generate free radicals, and affect the formation of lipofuscin, cause mitochondrial DNA mutation, induce apoptosis and protein synthesis, and then lead to cell damage, inflammation, and immunosuppression. , oxidative stress and disturbed hormone balance, leading to premature skin aging. Therefore, it is necessary to protect with antioxidant skin care products. [0003] Once the neutralizing free radicals with antioxidant capacity in antioxidants are consumed, they cannot be repeatedly generated, resulting in the current antioxidants in the market mostly in the form of high monomer content, that is, by increasing the amount of antioxidant components added. To ensure its antioxidant effect and stability, this an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61K8/46A61K8/02A61Q19/08A61Q1/02
CPCA61K8/498A61K8/4946A61K8/466A61K8/022A61Q19/08A61Q1/02A61K2800/592Y02A40/90
Inventor 张大勇毕永贤孔德承周浩淼陆雨清杜雨涵胡雪情唐萌
Owner ZHEJIANG YIGE ENTERPRISE MANAGEMENT GRP CO LTD
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