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Method for preparing shenqu by purebred fermentation

A pure-bred fermentation, Liushenqu technology, applied in the field of bioengineering, can solve problems such as large product differences and affecting the safety of Liushenqu use

Inactive Publication Date: 2016-01-27
王秋红
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The traditional process of preparing Liushenqu is to use naturally occurring microbial strains for fermentation under natural conditions and in specific seasons. Due to the different fermentation environments across the country and the differences in fermentation seasons, products from different origins or different batches of the same origin There are large differences in the products, or the introduction of miscellaneous bacteria such as aflatoxin, which seriously affects the safety of Liushenqu

Method used

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  • Method for preparing shenqu by purebred fermentation
  • Method for preparing shenqu by purebred fermentation
  • Method for preparing shenqu by purebred fermentation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: Laboratory fermentation of Penicillium chrysogenum to prepare Liushenqu

[0033] Weigh 25g each of dried Artemisia annua, dried cocklebur, and dried Polygonum punctatus, add 10 times the amount, 8 times the amount, and 6 times the amount of distilled water to decoct three times, each time for 40 minutes, combine the water decoction, concentrate to 250mL, transfer to 500mL to extinguish Put bacteria in Erlenmeyer flasks, seal them, put them in a clean workbench and let them cool for later use.

[0034] Weigh 500g of wheat bran, 500g of flour, 40g of bitter almond powder and 40g of red bean powder, put them in a 1000mL beaker, arrange eight layers of yarn in the middle of kraft paper, seal the mouth of the beaker, and place in a high-pressure steam sterilizer at 103.4kPa and 121.3°C Sterilize for 20 minutes, take it out immediately after sterilization, transfer to a clean workbench to cool down, and set aside.

[0035] Stir the above-treated concoction and 20g...

Embodiment 2

[0036] Embodiment 2: Production and preparation of Liushenqu by Penicillium chrysogenum

[0037] Weigh each 5kg of fresh Artemisia annua, cocklebur, and Polygonum punctatus, squeeze fresh juice, and use it as a binder for later use.

[0038] Weigh 30kg of wheat bran, 20kg of flour, 2kg of bitter almond powder and 2kg of red bean powder, mix the above-treated fresh juice and 100g of Penicillium chrysogenum into the sterile medium, mix evenly, and make 20×12×8cm The koji pieces are piled up in the shape of "pin", covered with wet material, cultivated for 10 days at 30°C and 75% relative humidity, until the yellow coat appears, stop the fermentation, take it out, and cut into about 1cm 3 Large and small bent pieces, dried, that is, this method is suitable for production use.

experiment example 1

[0039] Experimental Example 1: Investigation of Minimum Inhibitory Concentration

[0040] Liushenqu exerts the medicinal effect of inhibiting intestinal flora disorder through the antibacterial mechanism, so this experiment will investigate the antibacterial activity of Liushenqu fermentation raw materials, commercially available Liushenqu and pure Penicillium chrysogenum fermentation:

[0041] Sample A: Take 10g each of dried Artemisia annua, Cocklebur, and Polygonum capericum, 2g each of bitter almonds and red beans, add 10 times the amount, 8 times the amount, and 6 times the amount of distilled water to extract three times, each time for 1 hour, and combine the extracts. After concentration, it was dried under reduced pressure for 72 hours to obtain a thick paste of sample A, that is, no flour and wheat bran Liushenqu raw material extract;

[0042] Sample B: Take 100g of commercially available Liushenqu, add 10 times the amount, 8 times the amount, and 6 times the amount of ...

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Abstract

The invention relates to a method for preparing shenqu by purebred fermentation. The method is characterized by using Penicillium chrysogenum as a single fermentation bacterial strain, and employing six materials such as flour (and or wheat bran), red bean, bitter apricot kernel, sweet wormwood, water pepper, and Xanthium sibiricum to prepare a culture medium; the six materials are fermented under proper conditions to prepare medicine shenqu.

Description

technical field [0001] The invention relates to the field of bioengineering and the field of production of traditional Chinese medicinal materials, in particular to a method for preparing the traditional Chinese medicine Liushenqu by fermenting a pure strain of Penicillium chrysogenum (Penicillium chrysogenum). Background technique [0002] Medicated Leaven Massa (Medicated Leaven Massa), also known as Divine Comedy and Liuqu, is one of the commonly used digestive medicines. It is made from the natural juice of Artemisia annua, Xanthium, and Polygonum saponin mixed with bitter almond powder, red bean powder, wheat bran and flour. Mixed and fermented under suitable conditions, it is the most widely used traditional fermented koji. Liushenqu is sweet, pungent, warm in nature, and returns to the spleen and stomach meridians; it has the effects of promoting digestion, invigorating the stomach, and stopping diarrhea. [0003] The traditional process of preparing Liushenqu is to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/00C12N1/14A61P1/14C12R1/82
CPCA61K36/062A61K36/28A61K36/282A61K36/48A61K36/704A61K36/73A61K2236/19A61P1/14C12N1/14A61K2300/00C12P1/02
Inventor 王秋红匡海学王长福付新王荔慧薛娟
Owner 王秋红
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