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Novel process for preparation of glycine by using chloroacetic acid aqueous phase ammoniation method

A technology of glycine and chloroacetic acid, which is applied in the preparation of cyanide reaction, the preparation of organic compounds, chemical instruments and methods, etc., can solve the problems of difficult methanol mother liquor treatment, large centrifuge processing capacity, high production cost, etc., and reduce dissolution loss , reduce the processing volume and processing difficulty, and improve the yield

Inactive Publication Date: 2016-01-27
HEBEI DONGHUA JIHENG CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the purification method of this production process still adopts the method of directly adding methanol to extract the reaction liquid, which fails to solve the large amount of centrifugal separation caused by the use of a large amount of methanol, difficulty in post-processing of methanol mother liquor recovery, high production cost, and environmental impact. pollution problem

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] A new process for preparing glycine by chloroacetic acid aqueous phase ammonification method comprises the following steps:

[0044] A. Amination reaction

[0045] 183g (0.35 parts by mass) of urotropine solution with a mass concentration of 25%, and 523g (1 part by mass) of chloroacetic acid solution with a mass concentration of 82% were successively put into a 2L reaction bottle, and the pH value of the reaction solution was 6.8; Ammonia reaction was carried out with ammonia gas; the reaction temperature was controlled at 70°C~90°C, and the ammonia reaction reached the end of the reaction for 100 minutes, and the ammonia flow was stopped to complete the reaction; then the ammoniation reaction liquid was cooled to 25°C and filtered to obtain 413.6g of crude glycine , ammoniated mother liquor 559g.

[0046] The content of the glycine crude product is 60%, enter step B for purification.

[0047] Add 1120g (2 parts by mass) of methanol with a mass concentration of 92% t...

Embodiment 2

[0060] A new process for preparing glycine by chloroacetic acid aqueous phase ammonification method comprises the following steps:

[0061] A. Amination reaction

[0062] 185g (0.35 parts by mass) of urotropine solution with a mass concentration of 25%, and 528g (1 part by mass) of chloroacetic acid solution with a mass concentration of 81.8% were successively put into a 2L reaction bottle, and the pH value of the reaction solution was 7.1; Ammonia reaction was carried out with ammonia gas; the reaction temperature was controlled at 70°C to 90°C, and the ammonia reaction was carried out for 100 minutes to reach the end of the reaction, the ammonia flow was stopped, and the reaction ended; then the ammoniation reaction solution was cooled to 26°C and filtered to obtain 412g of crude glycine, Ammonia mother liquor 569g.

[0063] The content of the glycine crude product is 61%, enter step B for purification.

[0064] Add 1140g (2 parts by mass) of methanol with a mass concentra...

Embodiment 3

[0077] A new process for preparing glycine by chloroacetic acid aqueous phase ammonification method comprises the following steps:

[0078] A. Amination reaction

[0079] 165g (0.35 parts by mass) of urotropine solution with a mass concentration of 25%, and 472.6g (1 part by mass) of chloroacetic acid solution with a mass concentration of 81.8% were dropped into a 2L reaction flask in turn, and the pH value of the reaction solution was 7.5; Enter ammonia gas for ammoniation reaction; the reaction temperature is controlled at 80°C to 90°C, and the ammonia reaction reaches the end point of the reaction for 100 minutes, the ammonia flow is stopped, and the reaction ends; then the ammoniation reaction solution is cooled to 25°C and filtered to obtain crude glycine 368.2 g, ammoniated mother liquor 505g.

[0080]The content of the glycine crude product is 62%, enter step B for purification.

[0081] Add 1010g (2 parts by mass) of methanol with a mass concentration of 92% to 505g ...

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Abstract

The invention discloses a novel process for preparation of glycine by using a chloroacetic acid aqueous phase ammoniation method. The novel process comprises the following three processing steps: ammoniation reaction, purification of crude glycine, after-treatment of mother liquor. The process optimizes feeding parameters for preparation of the glycine by using the chloroacetic acid aqueous phase ammoniation method, and improves the purification method of the glycine, so yield of the glycine is significantly improved to 91% to 92% from original 84% to 86%; meanwhile, usage amount of methanol used for extraction is greatly reduced, wherein the usage amount of the methanol for production of per ton of the glycine is reduced by more than 25%, so treatment amount and treatment difficulty of the methanol mother liquid is significantly reduced; moreover, the novel process provided by the invention greatly reduces production cost and is significantly suitable for large-scale industrial production.

Description

technical field [0001] The invention relates to a new process for preparing glycine by chloroacetic acid aqueous phase ammonification method, which belongs to the field of glycine preparation. Background technique [0002] Glycine is also known as glycine, and its molecular formula is NH 2 CH 2 COOH is an important basic organic raw material and fine chemical product, widely used in organic chemical industry, medicine, food, pesticide, feed and other industries. For example, glycine is used in the pharmaceutical industry as an amino acid preparation, as a buffer for aureomycin, and as a raw material for the synthesis of other amino acids, such as phenylalanine, threonine, and serine. In terms of food, it is often added to various foods as a food additive for seasoning, sterilization, anti-corrosion, anti-oxidation, nutritional enhancement, etc., to facilitate the body's absorption and synthesis of other essential and non-essential amino acids in the body; it can be used al...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C229/08C07C227/08
Inventor 闫文忠仇荣庆王立辉李继忠陈建东刘国保李前锋王秀茹王娜高金辉
Owner HEBEI DONGHUA JIHENG CHEM
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