Preparation method of solution containing ambroxol hydrochloride and salbutamol sulfate
A technology of ambroxosalbutamol and salbutamol sulfate, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, and can solve problems such as easy production of by-products, unsustainable effects, and reduced effects , to achieve the effect of treating acute and chronic bronchitis, increasing the content of active ingredients and improving stability
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Embodiment 1
[0041] prescription:
[0042] Salbutamol sulfate: 10g;
[0043] Ambroxol hydrochloride: 20g;
[0044] Poloxamer 188: 8g;
[0045] Meglumine: 8g;
[0046] Mannitol: 4g;
[0047] Propylene glycol: 15g;
[0048] Methylparaben: 1g;
[0049] Stevioside: 8g;
[0050] Purified water: add to 5L.
[0051] Its preparation method is:
[0052] 1) Take by weighing 80% of the prescribed amount of purified water, add the prescribed amount of ambroxol hydrochloride, stir to make it dissolve completely, continue to add the prescribed amount of salbutamol sulfate, poloxamer 188, meglumine, mannitol and propylene glycol, 50 Stir at ℃ for 20min until completely dissolved;
[0053] 2) Add purified water to the full amount, add methyl p-hydroxybenzoate and stevioside, stir to dissolve, filter through a 0.45 μm microporous membrane, fill, seal, pass the inspection, pack, and get ready.
Embodiment 2
[0055] prescription:
[0056] Salbutamol sulfate: 10g;
[0057] Ambroxol hydrochloride: 20g;
[0058] Poloxamer 188: 10g;
[0059] Meglumine: 8g;
[0060] Mannitol: 4g;
[0061] Propylene glycol: 15g;
[0062] Methylparaben: 0.5g;
[0063] Sorbitol: 8g;
[0064] Purified water: add to 5L.
[0065] Its preparation method is:
[0066] 1) Take by weighing 70% of the prescribed amount of purified water, add the prescribed amount of ambroxol hydrochloride, stir to make it dissolve completely, continue to add the prescribed amount of salbutamol sulfate, poloxamer 188, meglumine, mannitol and propylene glycol, 50 Stir at ℃ for 20min until completely dissolved;
[0067] 2) Add purified water to the full amount, add methyl p-hydroxybenzoate and sorbitol, stir to dissolve, filter with a 0.45 μm microporous membrane, fill, seal, pass the inspection, pack, and get ready.
Embodiment 3
[0069] prescription:
[0070] Salbutamol sulfate: 8g;
[0071] Ambroxol hydrochloride: 15g;
[0072] Poloxamer 188: 8g;
[0073] Meglumine: 6g;
[0074] Mannitol: 2g;
[0075] Propylene glycol: 10g;
[0076] Methylparaben: 0.5g;
[0077] Sucrose: 6g;
[0078] Purified water: add to 5L.
[0079] Its preparation method is:
[0080] 1) Take by weighing 60% of the prescribed amount of purified water, add the prescribed amount of ambroxol hydrochloride, stir to make it dissolve completely, continue to add the prescribed amount of salbutamol sulfate, poloxamer 188, meglumine, mannitol and propylene glycol, 55 Stir at ℃ for 25min until completely dissolved;
[0081] 2) Add purified water to the full amount, add methyl p-hydroxybenzoate and sucrose, stir to dissolve, filter with a 0.45 μm microporous membrane, fill, seal, pass the inspection, pack, and get ready.
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