A kind of preparation method of Juyuan cough microcapsule

Abstract

A preparation method of a Juyuan cough relieving micro-capsule comprises the following steps: putting gelatin in a preparing pot, adding water, heating to 70 DEG C to dissolve the gelatin, thus obtaining a gelatin solution, adding Juyuan cough relieving dried cream powder, cooling to 50-55 DEG C, then adding ephedrine hydrochloride, menthol and tangerine oil, and finally sufficiently and evenly mixing by using a homogenizer, thus preparing a mixed solution; adding an acetic acid solution into the mixed solution to adjust pH to 3.6-3.8, adding an Na2SO4 solution, and stirring evenly to obtain a mixture; then adding a proper amount of water, stirring evenly to obtain suspension, starting cold water circulation to quickly cool to be below 10 DEG C, adding isopropanol, stirring, then adding a sodium hydroxide solution to adjust pH to 8-9, continuously stirring, standing for 20-24 hours, and separating a solid phase from a liquid phase, wherein the solid phase is the micro-capsule. The preparation method can obviously reduce the hygroscopicity of a preparation, the moisture deterioration possibility in drug production and storage process is small, leakage of essential oil can be prevented, loss of volatile components in the storage process is reduced, and the drug stability is improved.

Description

technical field [0001] The invention relates to the preparation of intermediates of Chinese patent medicine preparations, in particular to a preparation method of Juyuan cough microcapsules. Background technique [0002] Juyuan cough tablet is composed of platycodon grandiflorum, polygala extract, baibuliuying ointment, ephedrine hydrochloride, menthol, orange oil, and licorice seven flavors of traditional Chinese medicine. Juyuan Zhicough Tablets are collected in the National Compilation of Chinese Patent Medicine Standards. Internal Medicine Pulmonary System (II) Volume 370, the standard code is WS-11153 (ZD-1153)-2002. It has the effect of eliminating phlegm and relieving cough. Phlegm is not good. The standard prescription for Juyuan Zhike Tablets is 225g of Platycodon grandiflora, 75mL of polygala extract, 50mL of Baibu Liuying ointment, 5g of ephedrine hydrochloride, 0.67g of menthol, 1.3g of orange oil and 113g of licorice. The preparation method is as follows: pulv...

AI Technical Summary

Problems solved by technology

[0003] Currently, the commercially available Juyuan cough medicines are basically plain tablets and film-coated tablets. According to market sales, patient feedback and inspection of finished product samples, because this product contains menthol and volatile components of orange oil, the volatile oil will slow down during storage. Slow oozing, resulting in changes in the appearance of the finished product, and even mildew spots, making many patients afraid to use it with confidence

At the same time, Platycodon grandiflorum and licorice are directly used as medicines with the raw powder of medicinal materials. Although they have been sterilized at high temperature, the processing process will inevitably affect the active ingredients of the medicinal materials, thereby affecting the final curative effect. Risk of microbial excess

In addition, Juyuan Zhike Tablets are very susceptible to moisture and deterioration during storage, which affects the efficacy of the medicine and directly affects the effect of treatment.