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A drug nano lipid carrier-intraocular lens system and its application

A nano-lipid carrier and intraocular lens technology, applied in the field of medicinal chemistry, can solve problems such as slow and controllable release, and achieve the effects of increasing the effective concentration and prolonging the residence time.

Inactive Publication Date: 2018-01-30
中国医科大学附属第四医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved by the present invention is to use chemical bonds to load the drug nano-lipid carrier with sustained release on the intraocular lens to form a drug nano-lipid carrier-intraocular lens system, and implant the drug-loaded intraocular lens in cataract surgery, which can play a role. The effect of slow and controlled release of drugs to prevent postoperative complications

Method used

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  • A drug nano lipid carrier-intraocular lens system and its application
  • A drug nano lipid carrier-intraocular lens system and its application
  • A drug nano lipid carrier-intraocular lens system and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Add 75 mg of soybean lecithin to 10 ml of deionized water, put it on a magnetic stirrer and stir evenly, then add 225 mg of Cremophor EL and 45 mg of sodium deoxycholate (SDC), and stir evenly to prepare an aqueous phase. Mix caprylic / capric triglyceride Migyol 81278 mg, genistein 10 mg, and glyceryl behenate ATO888 105 mg, and stir evenly to prepare an oil phase. Heat the oil phase to 87°C, slowly add the water phase dropwise after the lipid is melted, continue to stir for 7 minutes after the water phase is added, ultrasonicate for 3s, interval 3s, 400w, 50 times, quickly put into ice water, shake evenly. The new hydrophilic acrylate intraocular lens IOL (Rayner Company) was taken out, washed with PBS, dried, and placed in a pre-configured mixed solution of acidic buffer and 1-ethyl-carbodiimide hydrochloride (EDC) for 10 minutes Afterwards, the intraocular lens IOL (Rayer Company, 570C) was placed in the anionic genistein nano-lipid carrier solution at 37°C for 12 hou...

Embodiment 2

[0052] Add 80 mg of soybean lecithin to 10 ml of deionized water, put it on a magnetic stirrer and stir evenly, then add 200 mg of Cremophor EL and 20 mg of sodium deoxycholate (SDC), and stir evenly to prepare an aqueous phase. Mix caprylic / capric triglyceride Migyol812 80mg, genistein 12mg, glyceryl behenate ATO888 100mg, stir well to prepare oil phase. Heat the oil phase to 80°C, slowly add the water phase dropwise after the lipid is melted, continue to stir for 10 minutes after the water phase is added, ultrasonicate for 3s, interval 3s, 500w, 40 times, quickly put into ice water, shake evenly. The brand-new intraocular lens IOL (Bausch & Lomb B&L Company, Akreos Adapt) was taken out, washed with PBS, dried, and placed in a pre-configured mixed solution of acidic buffer and 1-ethyl-carbodiimide hydrochloride (EDC) for 15 minutes Then place the IOL in the anionic genistein nano lipid carrier solution at 37° C. for 24 hours to prepare the genistein nano lipid carrier-intraoc...

Embodiment 3

[0054] Add 90 mg of egg yolk lecithin to 10 ml of deionized water, put it on a magnetic stirrer and stir evenly, then add 220 mg of Cremophor EL, 30 mg of sodium deoxycholate (SDC), and stir evenly to prepare an aqueous phase. Mix caprylic / capric triglyceride Migyol812 90mg, genistein 10mg, and glyceryl behenate ATO888 120mg, and stir evenly to prepare an oil phase. Heat the oil phase to 85°C, slowly add the water phase dropwise after the lipid is melted, continue to stir for 10 minutes after the water phase is added, ultrasonicate for 3s, interval 3s, 400w, 50 times, quickly put into ice water, shake evenly. The new hydrophilic acrylate intraocular lens IOL was taken out, washed with PBS and dried, placed in the pre-configured mixed solution of acidic buffer and 1-ethyl-carbodiimide hydrochloride (EDC) for 15 minutes, and then the IOLs were separated The pranoprofen nano-lipid carrier-intraocular lens drug delivery system was prepared by placing it in the anionic pranoprofen ...

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Abstract

The invention relates to a new establishing method of an artificial lens medicine carrying system. By means of the method, through a chemical bonding method, an artificial lens area and a button loop are evenly loaded with the transparent nanometer lipid medicine carrying system with a slow releasing effect, and therefore the system is implanted in the cataract surgery process, and the effect of treating and preventing postoperative complications is achieved. Medicine is prepared into nanometer lipid carriers with negative ions, the medicine is fixed into a lens bag through bonding of chemical bonds with a hydrophilic acrylic artificial lens as the carrier, and postoperative additional operation and dosage are not needed; the medicine is released in the lens bag, has better target performance and is better than a postoperative eyewash medicine which needs to permeate through corneas to be spread in atria; the nanometer lipid carrier can be slowly released in a controllable mode, and therefore the medicine effect can be achieved for a long time, and finally the effect of preventing and treating after-cataract, postoperative endophthalmitis, inflammatory responses and other cataract postoperative complications is achieved. By means of the method, the medicine carrying capacity can be remarkably improved, operation is simple and economical, and mass reproduction can be achieved.

Description

Technical field: [0001] The invention belongs to the technical field of medicinal chemistry, relates to a drug nano lipid carrier-intraocular lens system and its application, and also relates to the effect of the drug nano lipid carrier-intraocular lens system in preventing and treating postoperative complications. Background technique: [0002] Cataract surgery is one of the most common surgical operations in ophthalmology worldwide. Postoperative complications include endophthalmitis, inflammatory reaction, and post-cataract. The current routine postoperative dosage forms and methods are eye drops and ointments for ocular surface application of antibiotics and corticosteroids. The advantage of ocular surface administration is that the drug can directly reach the target site. , nasolacrimal duct drainage, etc.) and other factors, ocular surface drug administration has problems such as poor corneal permeability and low bioavailability, and frequent application of eye drops ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/16A61M31/00A61K9/127A61K45/06A61K47/28A61K31/352A61K31/573A61K31/5383A61K31/702A61P27/12
CPCA61F2/1602A61K9/0002A61K9/0051A61K9/127A61K31/352A61K31/5383A61K31/573A61K31/702A61K45/06A61K47/28A61M31/002A61M2210/0612
Inventor 孔珺潘卫三刘金璐张文骥李雪冬杨娜于世慧陈建亭
Owner 中国医科大学附属第四医院
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