Buccal patch containing artificial bezoar and metronidazole and preparation method of buccal patch

Abstract

The invention provides a buccal patch containing artificial bezoar and metronidazole and a preparation method of the buccal patch and belongs to the field of pharmaceutics. The buccal patch comprises 5%-60% by weight of the metronidazole and 0.25%-32% by weight of the artificial bezoar, and a binding agent is used as a binding sustained-release material and has the sustained-release effect. The buccal patch is prepared from the artificial bezoar and metronidazole compound, the anti-anaerobe first-choice drug metronidazole and the artificial bezoar are combined for use and are synergized for improvement of oral diseases such as periodontitis, dental ulcer and the like, and toxic and side effects are reduced; by means of the local administration mode of the buccal patch in the oral cavity, the drug bioavailability is improved, a drug degradation effect of a gastrointestinal fluid is prevented, the first-pass effect of the liver is avoided, and besides, compared with other oral mucosa drug delivery dosage forms, the buccal patch acts on the focus position easily and is not likely to be washed by saliva to enter the gastrointestinal tract; one or two of the main drugs including metronidazole and artificial bezoar is / are included, the bitter taste is relieved, and the flavor correcting function is realized.

Description

technical field [0001] The invention belongs to the field of pharmacy, and specifically relates to an oral patch that is used in the oral cavity and has a local or systemic therapeutic effect after being absorbed by the mucous membrane, and more specifically relates to a sustained-release artificial bezoar and metronidazole compound slow-release double-layer or Single layer oral patch. Background technique [0002] Metronidazole, as the drug of choice for anti-anaerobic bacteria, can effectively inhibit and kill periodontal pathogenic anaerobic bacteria such as Bacteroides melaninus, Bacteroides gingivalis, and Bacillus intermedius. Its main therapeutic mechanism is that after nitration, it is reduced by anaerobic bacteria, producing cytotoxic substances, inhibiting the synthesis of deoxyribonucleic acid of sensitive bacteria, and finally leading to the death of bacteria. [0003] Use Chinese and Western medicine compound to improve its adverse reactions. Artificial bezoar ...

AI Technical Summary

Problems solved by technology

[0005] The invention provides an artificial bezoar metronidazole oral patch and a preparation method thereof, in order to solve the problem that the amount of raw materials and auxiliary materials for oral administration in capsule form is large, and the key problem is that it causes serious liver first-pass effect in patients, and metronidazole stimulates the gastric mucosa Causes stomachache and other toxic side effects, and the problem of slow onset

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