High-frequency ultrasonic atomization particle preparation system with dynamic monitoring

Abstract

A dynamically-monitoring high-frequency ultrasonic nanometer atomizing granule preparation system, mainly consisting of a high-frequency ultrasonic nanometer atomizing device, a real-time multipoint dynamic nanoparticle size and state monitoring device (49, 50), an efficient laminar flow static electricity collecting device, an inert gas circulating and organic solvent recycling device, and a software automation control and data integration processing module (51); the system realizes a nanometer-scale preparation of a micro-sample, introduces real-time dynamic monitoring device, and timely monitors the effect of each parameter on the quality of nanoparticle via a data integration module or a software.

Description

technical field [0001] The present invention relates to the field of nanoparticle preparation and collection devices, in particular to a dynamic monitoring high-frequency ultrasonic atomization particle preparation system, more particularly, the system can monitor the parameters such as particle size and particle shape of nanoparticles in real time, for Provide guidance for further process optimization. The system is suitable for nanoparticle preparation of micro-sample, and has the advantage of high yield. Background technique [0002] As an important new delivery system, nanotechnology has brought great changes and developments in the fields of biomedicine, biotechnology and biomaterials, and has become a hot research direction in recent years. [0003] However, there are still many problems in the actual application of the existing nanocarrier preparation technology and equipment: [0004] (1) Unable to meet the needs of micro-sample preparation: In the early stage of r...

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Problems solved by technology

[0004] (1) Unable to meet the needs of micro-sample preparation: In the early stage of research and development, candidate compounds, biomaterials or biotechnology products are obtained in small quantities (milligram level) and are very precious. Researchers hope to complete their research with as few samples as possible. Evaluation of druggability, in vivo and in vitro activity

However, the minimum preparation amount of existing nanocarrier preparation equipment such as jet mill, ball mill, colloid mill, high-pressure homogenizer often requires several grams or even tens of grams of raw materials, and the preparation process requires multi-step operations, including crushing, Emulsification, drying, etc., the preparation process is cumbersome and complicated, and the yield is extremely low (gram-level samples, the yield is often lower than 50%)

This greatly limits the development of innovative products

[0005] (2) It cannot meet the needs of rapid preparation and stable storage of nano samples: common nanocarriers such as liposomes, nanocrystals, nanoparticles, etc. are mostly dispersed and prepared in a solution environment by the principles of homogenization, pulverization, and polymerization.

At present, there are many problems in the commonly used drying technology (freeze drying): low efficiency, long cycle, improper ingredients (such as protective agents, solvents, buffers, etc.) Stable storage of nano samples

[0006] (3) Unable to meet the needs of the integration of nano-sample detection and preparation: the particle size and particle shape of nanoparticles are important factors affecting their distribution in the body, target organ enrichment rate, drug efficacy and safety

Existing nano-preparation equipment cannot monitor and control the size and shape of particles on-line, and often requires repeated trials to determine the parameters of the process before formal sample preparation

This not only cannot meet the needs of micro-sample preparation in the early stage of research, but also has the hidden danger of uneven quality due to environmental changes in the mass production process

[0007] (4) Unable to meet the needs of green and environmentally friendly preparation of nano samples: due to poor water solubility, a large number of candidate drugs or new compounds need to be dissolved in special organic solvents before subsequent processing. Existing equipment lacks an organic solvent recovery system, and it is difficult for organic solvents to be completely recycled. recycling, but is discharged into the air, causing pollution

[0010] However, these commonly used nanocarrier preparation techniques require multi-step operations on the one hand, the preparation process is cumbersome and complicated, and the parameters are difficult to control; there are many problems in the commonly used drying technology (freeze drying): long cycle, ingredients (such as protective agents, solvents, buffers, etc.) etc.) or improper process selection can easily lead to unstable aggregation of nanocarriers, drug hydrolysis, etc., which requires targeted repeated trials

In addition, some products are highly toxic. If an open drying system is used, the exhaust gas must be clean, but the highly toxic substances in the exhaust gas cannot be completely removed by cyclone dust removal, bag dust removal, etc.

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