Quick on-line atmospheric photo ionization mass spectrum device for effective constituent in complex substrate

Abstract

The invention relates to a quick on-line atmospheric photo ionization mass spectrum device for an effective constituent in a complex substrate. The device comprises a pre-processing device, an atmospheric photo ionization source and a mass spectrometer, wherein the pre-processing device comprises an ultrasonic atomization mechanism, a volatile solvent introducing mechanism and a heating transfer mechanism. The device can be used for realizing the sensitive, quick and reliable qualitative and quantitative analysis after a to-be-detected sample containing complex substrate (such as, soil remained on explosion site, inferior milk power, food containing illegal additives, rootstocks of medicinal plants and the like) is directly put into the ultrasonic atomization mechanism and is subjected to ultrasonic atomization extraction, and then is delivered to and ionized at the front end of the atmospheric photo ionization source after being subjected to ultrasonic atomization and heating vaporization treatment and being converged with the volatile solvent. The device has wide application prospect at the aspects of discovery and identification of natural products, environment monitoring, criminal investigation, food safety, drug monitoring, etc.

Description

technical field [0001] The invention belongs to the technical field of analysis, and in particular relates to a fast online atmospheric pressure photoionization mass spectrometry device used for effective components inside a complex matrix. Background technique [0002] Compared with existing analysis methods, especially spectroscopic techniques (such as infrared, ultraviolet, fluorescence, etc.), mass spectrometry has attracted more and more attention in the field of analytical chemistry due to its advantages of high sensitivity, high specificity and high throughput. . At present, mass spectrometry has been widely used in the discovery and identification of natural products, environmental monitoring, criminal investigation, food safety and drug monitoring. However, due to the complexity of common untreated sample matrices (such as soil left over from explosion sites, poor-quality milk powder, foods containing illegal additives, and roots, stems and leaves of medicinal plan...

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Problems solved by technology

However, since the above-mentioned analysis method mainly ionizes the compound through ions or plasma generated by electrospray ionization and ultrasonic spray ionization, the ionization efficiency of weakly polar and non-polar compounds is low; secondly, as mentioned above, the above-mentioned analysis method uses thermal The analyte is desorbed by purging the surface of the sample with air flow or plasma air flow, so the substance inside the matrix is ​​still not desorbed or the desorption efficiency is very low, so it is more difficult to realize the quantitative analysis of the compound inside the matrix; on the other hand, During the desorption process, sometimes a strong airflow (such as DESI) is required to rush to the surface of the sample, so the sample in the particle phase (such as soil, milk powder, etc.) cannot be directly analyzed, otherwise it will bring serious pollution to the instrument

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