Preparation method of phosphorylated epimedium polysaccharide

A technology of Epimedium polysaccharide and phosphorylation, which can be applied in the direction of antitoxic agent, antiviral agent, drug combination, etc., can solve problems such as the blank of activity research.
CN105601760AActive Publication Date: 2016-05-25NANJING AGRICULTURAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NANJING AGRICULTURAL UNIVERSITY
Publication Date
2016-05-25

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Abstract

The invention belongs to the technical field of preparation and structural transformation of traditional Chinese medicine polysaccharide and relates to a preparation method of phosphorylated epimedium polysaccharide. The preparation method of the phosphorylated epimedium polysaccharide comprises the following steps: carrying out heating reaction on a phosphorylating reagent (sodium tripolyphosphate-sodium trimetaphosphate), epimedium polysaccharide and sodium sulfate for a period of time under alkaline condition, carrying out phosphorylation molecular modification, and selecting out optimal conditions for phosphorylation modification on the epimedium polysaccharide by carrying out a response surface experiment with content of phosphate radicals of products and reagent ratio, reaction temperature, reaction pH value and reaction time as factors. After the phosphorylated epimedium polysaccharide is prepared, in vitro activity of a modified product is studied, and results show that the phosphorylated epimedium polysaccharide has a certain immunoregulation, antiviral and antioxidant effects.
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Description

technical background

[0001] The invention belongs to the technical field of preparation and structural transformation of traditional Chinese medicine polysaccharides, and relates to a preparation method of phosphorylated epimedium polysaccharide (Phosphorylated Epimedium Polysaccharide, PEP). Background technique

[0002] Polysaccharides are an important class of macromolecular substances in organisms. They have pharmacological activities such as immune regulation, anti-virus, anti-tumor, blood sugar regulation, anti-aging, anti-oxidation, anti-inflammatory, antibacterial, and liver protection. They are widely used in clinical practice. Studies have shown that chemical modification of polysaccharides such as methylation, acetylation, sulfation, phosphorylation, and selenization can not only change the physical and chemical properties of polysaccharides, but also enhance the pharmacological activity of polysaccharides. For example, sulfated astragalus polysaccharides can sig...

Claims

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