Unlock instant, AI-driven research and patent intelligence for your innovation.

A temperature-sensitive multi-block polymer and its preparation method and application

A block polymer, temperature-sensitive technology, used in medical science, surgery, etc., can solve the problems of low hydrophobicity, easy damage, loss of anti-adhesion of PPO segments, and achieve excellent biocompatibility, easy Degradation, molecular weight reduction effect

Active Publication Date: 2017-09-29
SICHUAN UNIV
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(3) Due to the small hydrophobicity of the PPO chain segment, the poloxamer usually has a higher critical micelle concentration, so that it is easily destroyed after being injected into the human body, and is quickly excreted from the body, losing The role of anti-adhesion

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A temperature-sensitive multi-block polymer and its preparation method and application
  • A temperature-sensitive multi-block polymer and its preparation method and application
  • A temperature-sensitive multi-block polymer and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Under nitrogen protection, mix L-lactide, 10R5 with a mass ratio of 1 and 0.3% stannous octoate catalyst based on the total mass of 10R5 and L-lactide, stir and heat up to 140°C for 10h, and cool to room temperature , then add dichloromethane to dissolve the reaction product, and then put it into petroleum ether at -20°C for precipitation, filter, and repeat the operation 2 to 3 times before drying; dissolve the dry product in deionized water, and then use dialysis The bag is dialyzed to remove small molecular monomers and excess catalysts, and the dialyzed multi-block polymer is freeze-dried and sealed for storage.

[0051] The infrared spectrogram of the PLA-10R5-PLA multi-component block polymer test obtained in this embodiment is shown in figure 1 b in the test; the NMR spectrum of the test is shown in image 3 ; Its theoretical molecular weight Mn a 4.0×10 3 ; b 4.02×10 3 ; c 5.26×10 3 ; c 4.33×10 3 . The collection of illustrative plates of this multi-co...

Embodiment 2

[0053] Under the protection of nitrogen, mix L-lactide, 10R5 with a mass ratio of 0.25 and 0.3% stannous octoate catalyst based on the total mass of 10R5 and L-lactide, stir and heat up to 130 ° C for 7 hours, and cool to room temperature , then add tetrahydrofuran to dissolve the reaction product, and then put it into petroleum ether at -20°C for precipitation, filter, repeat the operation 2 to 3 times, and then dry; dissolve the dry product in deionized water, and then use a dialysis bag for dialysis The small molecule monomer and excess catalyst are removed, and the multi-block polymer after dialysis is freeze-dried and stored in a sealed container.

[0054] Theoretical molecular weight Mn of PLA-10R5-PLA multi-component block polymer obtained in the present embodiment a 2.5×10 3 ; b 2.66×10 3 ; c is 3.76×10 3 ; c 2.59×10 3 .

Embodiment 3

[0056] Under nitrogen protection, mix L-lactide, 10R5 with a mass ratio of 0.75 and 0.3% stannous octoate catalyst based on the total mass of 10R5 and L-lactide, stir and heat up to 160°C for 5 hours, and cool to room temperature , then add dichloromethane and chloroform (1:1, v:v) to dissolve the reaction product, and then put it into petroleum ether at -20°C for precipitation, filter, and repeat the operation 2 to 3 times before drying; Dissolving the dried product in deionized water, and then using a dialysis bag to dialysis to remove small molecular monomers and excess catalyst, and the multi-component block polymer after dialysis is freeze-dried and sealed for storage.

[0057] Theoretical molecular weight Mn of PLA-10R5-PLA multi-component block polymer obtained in the present embodiment a 3.5×10 3 ; b is 3.68×10 3 ; c is 4.79×10 3 ; c is 3.61×10 3 .

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Theoretical molecular weightaaaaaaaaaa
Theoretical molecular weightaaaaaaaaaa
Login to View More

Abstract

The invention discloses temperature-sensitive type multielement block copolymer. According to the temperature-sensitive type multielement block copolymer, under the protection of inert gases, L-lactide and trans poloxamer are mixed with a catalyst according to the mass ratio of 0.185-1.4, a heating reaction is conducted for 5-12 hours at the temperature of 130-160 DEG C, cooling is conducted, then solvent is added to dissolve a product obtained through the reaction, then sediment, filtering, drying and purification are conducted, the structural formula PLA-10R5-PLA or PLA-17R4-PLA is obtained, the number-average molar mass Mn<c> of the PLA-10R5-PLA is 3.73-5.69*10<3>, the number-average molar mass Mn<c> of the PLA-17R4-PLA is 3.37-5.69*10<3>, the concentration of temperature-sensitive type hydrogel prepared by the multielement block copolymer is larger than or equal to 10wt%, and the temperature of critical gel is higher than or equal to 25 DEG C. By means of the multielement block copolymer, the hydrogel is formed under a low critical gel concentration, preparation cost is low, the temperature-sensitive type multielement block copolymer has gel sol transformation characteristics and is biodegradable, the antiblocking effect and biocompatibility are good, and a novel variety is provided for medical antiblocking materials.

Description

technical field [0001] The invention belongs to the technical field of multi-component block polymers and their preparation and application, and in particular relates to a polylactic acid-modified trans-poloxamer temperature-sensitive multi-block polymer and its preparation method and application. Background technique [0002] Postoperative adhesion is the main cause of postoperative complications such as intestinal obstruction, infertility, and pain. It is also a problem that has not been solved in the surgical field for a long time. Scientists have been working hard to find various methods to prevent postoperative adhesion . [0003] In recent years, it has become a new trend in the world to prevent postoperative adhesions by implanting isolation materials in the parts prone to postoperative adhesions, such as the reported use of anti-adhesion films, anti-adhesion hydrogels, anti-adhesion liquids, etc., these Materials have their own advantages, but also have their disadv...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C08G63/08C08G63/85A61L31/06A61L31/14
CPCA61L31/06A61L31/145C08G63/08C08G63/85C08L67/04
Inventor 郭刚危加丽
Owner SICHUAN UNIV