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A kind of hydroxyapatite toothpaste and preparation method thereof

A hydroxyapatite and nano-hydroxyapatite technology, which is applied in the field of daily daily chemicals, can solve the problems of irreparable dentin and easy failure of nano-hydroxyapatite, and achieves the promotion of mineralization process, reduction of pore size, raw material low cost effect

Active Publication Date: 2018-04-24
HANGZHOU JIAOJIE ORAL HEALTH CARE PRODS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For this reason, the technical problem to be solved by the present invention is to overcome the problem that nano-hydroxyapatite in the existing hydroxyapatite toothpaste is prone to failure, thereby causing the problem that the dentin cannot be repaired, thereby providing a hydroxyapatite that can effectively repair the dentin Stone toothpaste and preparation method thereof

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  • A kind of hydroxyapatite toothpaste and preparation method thereof
  • A kind of hydroxyapatite toothpaste and preparation method thereof
  • A kind of hydroxyapatite toothpaste and preparation method thereof

Examples

Experimental program
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Embodiment 1

[0059] This embodiment provides a hydroxyapatite toothpaste, which is calculated by mass percentage and consists of the following raw materials:

[0060] Calcium hydrogen phosphate dihydrate 12wt%, hydrated silica 10wt%, carrageenan 2wt%, glycerin 28wt%, sucralose 0.1wt%, zinc citrate 0.05wt%, sodium lauryl sulfate 2wt%, monofluorophosphoric acid Sodium 0.76wt%, peppermint flavor 1.25wt%, lemon yellow pigment 0.005wt%, micron hydroxyapatite 4wt%, nano hydroxyapatite 1wt%, and the balance is deionized water.

[0061] The method for preparing hydroxyapatite toothpaste includes the following steps:

[0062] S1. Put the above components in a mixer and stir at 800rpm for 40min;

[0063] S2, vacuum degass into a paste.

[0064] Such as figure 1 As shown, the average particle size of micron hydroxyapatite is 2μm; figure 2 As shown, the average particle size of nano-hydroxyapatite is 60 nm.

Embodiment 2

[0066] This embodiment provides a hydroxyapatite toothpaste, which is calculated by mass percentage and consists of the following raw materials:

[0067] Calcium hydrogen phosphate dihydrate 12wt%, carrageenan 2wt%, glycerin 28wt%, sucralose 0.1wt%, zinc citrate 0.05wt%, sodium lauryl sulfate 2wt%, sodium monofluorophosphate 0.76wt%, peppermint flavor 1.25wt%, lemon yellow pigment 0.005wt%, hydrated silica 10wt%, micron hydroxyapatite 3wt%, nano-hydroxyapatite 2wt%, and the balance is deionized water.

[0068] The average particle size of micron hydroxyapatite is 2 μm, and the average particle size of nano-hydroxyapatite is 60 nm.

[0069] The preparation method of hydroxyapatite toothpaste includes the following steps:

[0070] S1. Put the above components in a mixer and stir at 800rpm for 40min;

[0071] S2, vacuum degass into a paste.

Embodiment 3

[0073] This embodiment provides a hydroxyapatite toothpaste, which is calculated by mass percentage and consists of the following raw materials:

[0074] Silica 40wt%, xanthan gum 0.02wt%, polyethylene glycol 40010wt%, methyl paraben 0.1wt%, sodium lauroyl sarcosinate 0.1wt%, sodium fluoride 8wt%, brilliant blue pigment 0.001wt %, micron hydroxyapatite 20wt%, nano hydroxyapatite 10wt%, and the balance is deionized water.

[0075] The average particle size of micron hydroxyapatite is 3 μm, and the average particle size of nano-hydroxyapatite is 80 nm.

[0076] The method for preparing hydroxyapatite toothpaste includes the following steps:

[0077] S1. Put the above components in a mixer and stir for 20 minutes at 100 rpm;

[0078] S2, vacuum degass into a paste.

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Abstract

The invention relates to hydroxyapatite toothpaste which comprises micron-order hydroxyapatite, nano-hydroxyapatite and fluoride. The grain size of the micron-order hydroxyapatite ranges from 0.1 micrometer to 10 micrometers, and the grain size of the nano-hydroxyapatite is smaller than 100 nm. The mass concentration of fluorine of fluoride in the hydroxyapatite toothpaste is not larger than 8.0 wt%, the mass content of the nano-hydroxyapatite is not larger than 20 wt%, and the mass ratio of the micron-order hydroxyapatite to the nano-hydroxyapatite is 1:10 to 18:1. When the hydroxyapatite toothpaste is used, demineralized dentine sheets are helped to be subjected to biomineralization, the dentin sheets are restored, the aperture of the dental canaliculi is reduced, and even the dentinal tubule is blocked or a hydroxyapatite layer is deposited on the surface of the dentin. At the same time, fluoride matched with the content of the micron-order hydroxyapatite and the content of the nano-hydroxyapatite is hydrolyzed to generate fluorinions, the mineralization process of the hydroxyapatite in the dentin is promoted, and the restoring function of the hydroxyapatite toothpaste on the dentin is remarkably improved.

Description

Technical field [0001] The invention belongs to the technical field of daily chemicals, and in particular relates to a hydroxyapatite toothpaste toothpaste with restoration of dentin and a preparation method thereof. Background technique [0002] Toothpaste has become a necessity in people's daily life. With the continuous improvement of people's living standards, toothpaste has developed from an ordinary tooth-cleaning type to a curative type. [0003] In terms of its curative effect, there are mainly anti-inflammatory and hemostatic, desensitizing and anti-tartar toothpastes, or mixed toothpastes with the above curative effects. Although these drug toothpastes have a certain effect on preventing and curing dental diseases, they have no function of restoring dentin. However, due to changes in the dietary structure, they are often eroded by acidic substances, and the surface of the teeth loses enamel, exposing fragile dentin materials and holes on the surface that can penetrate de...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/24A61K8/02A61K8/20A61Q11/00
CPCA61K8/0241A61K8/20A61K8/24A61K2800/412A61K2800/413A61Q11/00
Inventor 丁观军程吉平吴兴合
Owner HANGZHOU JIAOJIE ORAL HEALTH CARE PRODS