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Injectable self-healing hydrogel based on methyl vinyl ether-maleic acid copolymer/sodium alginate oxide and preparation method thereof

A technology of methyl vinyl ether and maleic acid copolymer, applied in medical science, prosthesis, etc., can solve the problems of difficult biocompatibility, complex synthesis steps, etc., and achieve high-efficiency intelligent function and mechanical strength Good, short cycle effect

Inactive Publication Date: 2016-06-08
SOUTHEAST UNIV
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Problems solved by technology

[0005] The object of the present invention is to provide a kind of injectable self-healing hydrogel based on methyl vinyl ether maleic acid copolymer (P(MVE-alt-MA)) / oxidized sodium alginate (OSA) and preparation method thereof, In order to solve the complex synthesis steps of traditional polymer hydrogels in the prior art, it is not easy to simultaneously satisfy the requirement that the hydrogel has good biocompatibility, and the precursor solution of the hydrogel can be rapidly molded and solidified at the target site and still have certain properties after solidification. Defects such as mechanical properties

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  • Injectable self-healing hydrogel based on methyl vinyl ether-maleic acid copolymer/sodium alginate oxide and preparation method thereof
  • Injectable self-healing hydrogel based on methyl vinyl ether-maleic acid copolymer/sodium alginate oxide and preparation method thereof

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preparation example Construction

[0030] The above-mentioned preparation method based on methyl vinyl ether maleic acid copolymer / oxidized sodium alginate injectable self-healing hydrogel comprises the following steps:

[0031]Step 1: Methyl vinyl ether maleic anhydride copolymer (P(MVE-alt-MAH)) was stirred in secondary water at 90°C for 2 hours and hydrolyzed to obtain a water-soluble methyl vinyl ether maleic acid copolymer; The cross-linking agent ADH is added to the P(MVE-alt-MA) aqueous solution, and the catalyst EDC / NHS is added to the above reaction solution. The pH of the reaction solution was adjusted to 4-6, and the reaction was carried out at room temperature for 24 h. After dialysis for 3 to 7 days, the product was freeze-dried to obtain ADH-g-P(MVE-alt-MA);

[0032] Among them, the molar ratio of P(MVE-alt-MA) to ADH is 1:30~1:5; the molar ratio of EDC and NHS is 0.5:1~1:1.5; the total amount of catalyst (ie EDC and NHS) and P The molar ratio of (MVE-alt-MA) is 1:50~2;

[0033] The number aver...

Embodiment 1

[0038] (1) Synthesis of ADH-g-P (MVE-alt-MA)

[0039] Take 0.1g of methyl vinyl ether maleic anhydride copolymer P (MVE-alt-MAH) in 30ml of secondary water at 90°C for 2 hours and hydrolyze to obtain water-soluble methyl vinyl ether maleic acid copolymer P (MVE-alt-MA), cooled and then added 7.5 mmol ADH. 1mmolEDC and 1mmolNHS were dissolved in 2ml of water, and then added to the reaction solution. The pH of the reaction solution was adjusted to 6, and the reaction was carried out at room temperature for 24h. The product was dialyzed in deionized water for 3 to 7 days with a dialysis bag with a molecular weight cut-off of 3500, and then freeze-dried to obtain ADH-g-P (MVE-alt-MA) with a grafting rate of 53%.

[0040] (2), the synthesis of OSA

[0041] Dissolve 1.0g of sodium alginate in 100mL of deionized water to make a 1% sodium alginate solution, then add 0.22g of sodium periodate to it, and stir for 5 hours at 25°C in the dark. After the reaction is complete, add 2mL E...

Embodiment 2

[0046] (1) Synthesis of ADH-g-P (MVE-alt-MA)

[0047] Take 0.1g of methyl vinyl ether maleic anhydride copolymer P (MVE-alt-MAH) in 30ml of secondary water at 90°C for 2 hours and hydrolyze to obtain water-soluble methyl vinyl ether maleic acid copolymer P (MVE-alt-MA), cooled and then added 3.5 mmol ADH. 1 mmol of EDC and 1 mmol of NHS were dissolved in 2 ml of water, respectively, and then added to the reaction solution. The pH of the reaction solution was adjusted to 6, and the reaction was carried out at room temperature for 24 h. The product was dialyzed in deionized water for 3 to 7 days with a dialysis bag with a molecular weight cut off of 3500, and then freeze-dried to obtain ADH-g-P (MVE-alt-MA) with a grafting rate of 16%.

[0048] (2), the synthesis of OSA

[0049] Dissolve 1.0g of sodium alginate in 100mL of deionized water to make a 1% sodium alginate solution, then add 1.0g of sodium periodate to it, and stir for 5 hours at 25°C in the dark. After the reactio...

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Abstract

The invention discloses an injectable self-healing hydrogel based on methyl vinyl ether-maleic acid copolymer / sodium alginate oxide and a preparation method thereof. This hydrogel is in mesh structure; the hydrogel that is injectable and self-healable is obtained by: subjecting ADH-g-P(MVE-alt-MA) and sodium alginate oxide to dehydration-condensation reaction in phosphate buffer solution at 37 DEG C to generate reversible acylhydrazone bonds, wherein ADH-g-P(MVE-alt-MA) is obtained by modifying methyl vinyl ether-maleic acid copolymer via adipic dihydrazide, and the sodium alginate oxide is obtained by oxidize-reacting sodium periodate with sodium alginate. The invention has the advantages that a synthetic process of the self-healing hydrogel is simple and green with mild reaction conditions, the hydrogel can gelatinize and self-heal at room temperature, and the hydrogel has a promising application prospect in the biomedical fields such as drug sustained release and cellular 3D culture carriers.

Description

technical field [0001] The invention relates to the field of hydrogel preparation, in particular to an injectable self-healing hydrogel based on methyl vinyl ether maleic acid copolymer P(MVE-alt-MA) / oxidized sodium alginate OSA and a preparation method thereof . Background technique [0002] Polymer hydrogel (Hydrogel) is a kind of polymer material cross-linked by covalent or non-covalent bonds, which can swell in water, maintain a certain shape and have a three-dimensional network. Polymer hydrogels have broad application prospects in biomedical fields such as drug sustained release, biosensors, and tissue engineering due to their unique properties such as high water content, viscoelasticity, and environmental responsiveness. Injectable hydrogels are a class of smart hydrogels that can inject a precursor solution (aqueous solution composed of hydrogel-forming components) to a target site through a syringe, and undergo a solution-gel transition in situ. Material. Because...

Claims

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Application Information

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IPC IPC(8): C08G81/02C08J3/075C08F8/30C08F216/18C08B37/04A61L27/50A61L27/18
CPCA61L27/18A61L27/50C08B37/0084C08F8/30C08G81/02C08J3/075C08J2387/00C08F216/18C08L87/00
Inventor 张天柱马晓娥周乃珍
Owner SOUTHEAST UNIV
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