A polymer vesicle with imitation virus structure and its preparation method and application

A technology of polymer vesicles and polymer solutions, which can be applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulations, etc. High production efficiency, good repeatability, simple and feasible process
CN105694399BActive Publication Date: 2018-06-22SOUTH CHINA UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SOUTH CHINA UNIV OF TECH
Publication Date
2018-06-22

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Abstract

The invention belongs to the field of high polymer materials and discloses a virus structure-imitated high-polymer vesica as well as a preparation method and application thereof. The virus structure-imitated high-polymer vesica is prepared from different amphipathic block copolymers through self-assembling or is prepared from amphipathic block copolymers and water-soluble polymers through self-assembling. The virus structure-imitated high-polymer vesica comprises a capsid membrane structure and a spike structure on the surface of a membrane, wherein the inner layer and the outer layer of the capsid membrane structure consist of hydrophilic chain segments in the amphipathic block copolymers or the water-soluble polymers, and an intermediate layer between the inner layer and the outer layer consists of hydrophobic chain segments in the amphipathic block copolymers. The high-polymer vesica has a virus-imitated specific structure and is controllable in structure, high in repeatability, capable of carrying drugs, good in biocompatibility and easy to be phagocytized by cells; the operation of the method is simple, and the production efficiency is high; and meanwhile, the high-polymer vesica can be applied to the relevant fields of high-efficiency nano-carriers, controlled release of medicines and cell imaging.
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Description

technical field

[0001] The invention belongs to the field of polymer materials, and relates to a polymer vesicle with imitation virus structure, in particular to a polymer vesicle with imitation virus nucleocapsid and surface spike structure, a preparation method and application thereof. Background technique

[0002] As the simplest type of non-cellular microorganisms, viruses are mainly composed of nucleic acid molecules and protein capsids; their basic structure has a core (nucleic acid) and a capsid (protein or lipoprotein), both of which constitute the nucleocapsid. The unique capsid structure of the virus can shield potential damaging factors in the internal circulation environment, such as nucleases, pH, etc., and has the function of protecting genetic material. On the surface of some virus particles (especially on the surface of enveloped virus particles), there are radially arranged protrusions, which are called spikes (also called envelope protrusions). Some of the...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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