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Gingko general flavone sublingual tablet and preparation method thereof

A technology of total ginkgo flavonoids and sublingual tablets, which is applied in the direction of medical formulas, medical preparations containing no active ingredients, medical preparations containing active ingredients, etc., can solve the problem of no sublingual tablet preparations, etc., and achieve good taste and easy to take And easy to carry, improve the effect of compliance

Active Publication Date: 2016-07-06
HUNAN UNIV OF SCI & ENG +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many ginkgolide preparations disclosed at present, but there are no sublingual tablet preparations. The drug avoids the damage to the drug by the digestive enzymes in the gastrointestinal tract and the first-pass metabolism of the liver, improves the bioavailability, enables the drug to be absorbed quickly, and rapidly exerts its efficacy

Method used

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  • Gingko general flavone sublingual tablet and preparation method thereof
  • Gingko general flavone sublingual tablet and preparation method thereof
  • Gingko general flavone sublingual tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A sublingual tablet of total ginkgo flavonoids, which is made from 50 g of total ginkgo flavonoids, 90 g of pregelatinized starch, 25 g of microcrystalline cellulose, and 3 g of magnesium stearate; Cortexin 40%, isorhamnetin 35%, kaempferol 25%.

[0026] The specific preparation method is as follows: dry, pulverize, and sieve the above-mentioned main drug total flavonoids of ginkgo biloba, pregelatinized starch, microcrystalline cellulose and magnesium stearate; Debonding agent, use pure water and ethanol as binder to make the mixed material into soft material, granulate with 40 mesh sieve; and dry at 60°C until the moisture content is ≤3%; then add the lubricant The dry granules obtained above are mixed together, and finally compressed into tablets to obtain sublingual tablets of ginkgo total flavonoids.

[0027] The total ginkgo flavonoids sublingual tablet prepared in this example has a disintegration time of 2min25s.

Embodiment 2

[0029] A kind of ginkgo total flavonoids sublingual tablet, it is made of ginkgo total flavonoids 50g, alginic acid 56g, microcrystalline cellulose-mannitol 55g, thaumatin 1.5g, pine mucilage 2.5g, stearic acid 1.5g, talcum powder 1g Made; the ginkgolide contains the following components in mass fraction: 45% isorhamnetin, 20% quercetin, 35% kaempferol.

[0030] The specific preparation method is as follows: the above-mentioned components are pretreated by drying, pulverizing and sieving; after mixing evenly, they are directly compressed into tablets to obtain sublingual tablets of ginkgo total flavonoids.

[0031] The total ginkgo flavonoids sublingual tablet prepared in this example has a disintegration time of 2min28s.

Embodiment 3

[0033] A sublingual tablet of ginkgo total flavonoids, which is made of 80 g of total ginkgo flavonoids, 35 g of gelatin, 55 g of microcrystalline cellulose, 2.5 g of xylitol, 11 g of cocklebur powder, 2.5 g of polyethylene glycol 4000, and 1.5 g of polyethylene glycol 6000 As a result, the ginkgolide contains the following components in mass fractions: 40% quercetin, 15% kaempferol, and 45% isorhamnetin.

[0034] The specific preparation method is as follows: the above-mentioned components are dried, pulverized, and sieved for pretreatment; then the components except polyethylene glycol 6000 and polyethylene glycol 4000 are mixed evenly, and the dry granulator is used to make 40-mesh The granules are added with polyethylene glycol 6000 and polyethylene glycol 4000, and compressed into tablets to obtain sublingual tablets of ginkgo total flavonoids.

[0035] The total ginkgo flavonoids sublingual tablet prepared in this example has a disintegration time of 2min17s.

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Abstract

The invention discloses a gingko general flavone sublingual tablet and a preparation method thereof.The sublingual tablet is prepared from, by weight, 1-260 parts of gingko general flavone, 2-25 parts of disintegrating agent and 35-245 parts of filler.Gingko general flavone is prepared from, by weight, 35-50% of quercetin, 6-16% of kaempferide and 15-25% of isorhamnetin.The gingko general flavone sublingual tablet is prepared by organically combining disintegrating agent with filler, and the tablet is put under a tongue when taken and can be rapidly disintegrated and absorbed by sublingual mucosal and directly enter blood circulation through jugular veins and superior vena cava to rapidly act so as to rapidly relieve migraine symptoms.Meanwhile, the tablet is particularly suitable for the aged and other patients having difficulty in swallowing and patients having difficulty in taking water in special environments such as battlefields, outdoor environments and tourist environments.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a sublingual tablet of ginkgo total flavonoids and a preparation method thereof. Background technique [0002] Ginkgo biloba preparations are currently one of the most important drugs used for the treatment and prevention of cardiovascular and cerebrovascular diseases in the world and at home, and are also the herbal medicines with the largest sales volume and widest acceptance. my country's ginkgo resources account for more than 70% of the world's total resources. The annual output of ginkgo leaves is as high as 20,000 tons, and the annual output of ginkgo leaf standard extracts is more than 100 tons. The raw materials are sufficient. The raw materials of foreign ginkgo products also mainly come from my country. Ginkgo leaves and The export value of Ginkgo biloba standard extract occupies the first place among Chinese herbal medicines in my country. But the research and utilizatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/352A61K47/36A61K47/26A61P9/10A61P7/02A61P25/00A61P11/06
CPCA61K9/006A61K9/2018A61K9/2059A61K31/352A61K2300/00
Inventor 何福林陈小明盘俊曾飞姜红宇李治章吕宏再
Owner HUNAN UNIV OF SCI & ENG
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