Gingko general flavone sublingual tablet and preparation method thereof
A technology of total ginkgo flavonoids and sublingual tablets, which is applied in the direction of medical formulas, medical preparations containing no active ingredients, medical preparations containing active ingredients, etc., can solve the problem of no sublingual tablet preparations, etc., and achieve good taste and easy to take And easy to carry, improve the effect of compliance
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Embodiment 1
[0025] A sublingual tablet of total ginkgo flavonoids, which is made from 50 g of total ginkgo flavonoids, 90 g of pregelatinized starch, 25 g of microcrystalline cellulose, and 3 g of magnesium stearate; Cortexin 40%, isorhamnetin 35%, kaempferol 25%.
[0026] The specific preparation method is as follows: dry, pulverize, and sieve the above-mentioned main drug total flavonoids of ginkgo biloba, pregelatinized starch, microcrystalline cellulose and magnesium stearate; Debonding agent, use pure water and ethanol as binder to make the mixed material into soft material, granulate with 40 mesh sieve; and dry at 60°C until the moisture content is ≤3%; then add the lubricant The dry granules obtained above are mixed together, and finally compressed into tablets to obtain sublingual tablets of ginkgo total flavonoids.
[0027] The total ginkgo flavonoids sublingual tablet prepared in this example has a disintegration time of 2min25s.
Embodiment 2
[0029] A kind of ginkgo total flavonoids sublingual tablet, it is made of ginkgo total flavonoids 50g, alginic acid 56g, microcrystalline cellulose-mannitol 55g, thaumatin 1.5g, pine mucilage 2.5g, stearic acid 1.5g, talcum powder 1g Made; the ginkgolide contains the following components in mass fraction: 45% isorhamnetin, 20% quercetin, 35% kaempferol.
[0030] The specific preparation method is as follows: the above-mentioned components are pretreated by drying, pulverizing and sieving; after mixing evenly, they are directly compressed into tablets to obtain sublingual tablets of ginkgo total flavonoids.
[0031] The total ginkgo flavonoids sublingual tablet prepared in this example has a disintegration time of 2min28s.
Embodiment 3
[0033] A sublingual tablet of ginkgo total flavonoids, which is made of 80 g of total ginkgo flavonoids, 35 g of gelatin, 55 g of microcrystalline cellulose, 2.5 g of xylitol, 11 g of cocklebur powder, 2.5 g of polyethylene glycol 4000, and 1.5 g of polyethylene glycol 6000 As a result, the ginkgolide contains the following components in mass fractions: 40% quercetin, 15% kaempferol, and 45% isorhamnetin.
[0034] The specific preparation method is as follows: the above-mentioned components are dried, pulverized, and sieved for pretreatment; then the components except polyethylene glycol 6000 and polyethylene glycol 4000 are mixed evenly, and the dry granulator is used to make 40-mesh The granules are added with polyethylene glycol 6000 and polyethylene glycol 4000, and compressed into tablets to obtain sublingual tablets of ginkgo total flavonoids.
[0035] The total ginkgo flavonoids sublingual tablet prepared in this example has a disintegration time of 2min17s.
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