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Liquid disinfectant

A disinfectant and liquid technology, applied in the direction of disinfectant, antiviral agent, biocide, etc., can solve the problems of carcinogenicity, severe stimulation, teratogenicity and toxicity, and achieve the effect of ensuring safety

Inactive Publication Date: 2016-07-13
SHANDONG WEIGAO PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disinfectant contains aldehyde components such as glutaraldehyde, citral, jasmonaldehyde, and myristaldehyde. Some of these aldehydes have serious irritating effects on human eyes and skin, and have strong carcinogenic and teratogenic effects. Sexual toxicity, cannot be used for disinfection of personnel and environment in assisted reproductive centers

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0030] Table 1 is each component content of embodiment 1-11, and the unit in the table is parts by weight

[0031] Table 1

[0032]

experiment example 1

[0034] Sterilization effect experiment

[0035] Inspection basis: "Technical Specifications for Disinfection" issued by the Ministry of Health in 2002

[0036] Experimental strains: Escherichia coli (8099), Staphylococcus aureus (ATCC6538), Candida albicans (ATCC10231)

[0037] Test temperature: 20°C

[0038] Sterilization time: 1min

experiment example 2

[0047] Germ cytotoxicity test

[0048] Grouping and handling of experimental animals:

[0049] After 1 week of adaptive feeding, 36 KM mice were randomly divided into 2 groups: Group A Example 5, Group B with 75% ethanol, and Group C with normal saline, 12 males in each group. Group A was gavaged with 0.5 mL of the disinfectant solution of Example 5, group B was gavaged with 0.5 mL of 75% ethanol, and group C was gavaged with 0.5 mL of normal saline, once a day, for 9 consecutive weeks.

[0050] At the end of the 9th week, 6 male mice were randomly selected from groups A, B, and C, and the bilateral epididymis were taken out, placed in normal saline, the capsule was separated, the epididymis were cut into pieces, and the filtrate was centrifuged at 1000r / min for 2min after filtration. After discarding the supernatant, make a suspension smear, fix with methanol for 15 minutes, stain with 0.5% eosin for 1 minute, place it on a slide rack to dry, observe the sperm morphology und...

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Abstract

The invention provides a liquid disinfectant.The liquid disinfectant is characterized by comprising, by weight, 0.1-2.0 parts of polyhexamethylene biguanidine hydrochloride, 0.05-0.5 part of quaternary ammonium salt, 0.5-5 parts of glycerinum, 0.1-1 part of a non-ionic surface active agent and 90-99 parts of water.The liquid disinfectant has the advantages that volatile organic carbon compounds poisoning sperms, eggs and embryos are not contained; the broad spectrum fungicide PHMB is adopted for replacing aldehydes carcinogenicity compounds in the prior art and has no irritation or mutagenicity; no urea is contained; the glycerinum and the non-ionic surface active agent can improve permeability of bacterial cell walls, the penetrating power of polyhexamethylene biguanidine hydrochloride and quaternary ammonium salt on the bacterial cell walls is improved, and the sterilization effect is good; due to vitamin E, the sterilization effect can be improved, the embryo survival probability is increased, skin aging of medical workers is avoided, and injuries of the disinfectant to skin are avoided.

Description

technical field [0001] The invention belongs to the field of disinfectants, and in particular relates to a liquid disinfectant used for disinfecting the environment and personnel of assisted reproductive technology. Background technique [0002] Assisted reproductive technology is the abbreviation of assisted reproductive technology (Assisted Reproductive Technology, ART), which refers to the technology of using medical assistance to make infertile couples pregnant, including artificial insemination (Artificial Insemination, AI) and in vitro fertilization-embryo transfer (InVitroFertilizationandEmbryoTransfer, IVF-ET) and its derivative technologies. [0003] The environment and personnel disinfection of assisted reproductive technology is an important means to ensure the success of assisted reproductive technology. Therefore, assisted reproductive technology has strict disinfection and isolation measures: the staff entering the laboratory must change into slippers. After ch...

Claims

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Application Information

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IPC IPC(8): A01N47/44A01N33/12A01P1/00A61K31/155A61K31/14A61P31/04A61P15/08A61P31/12A61K31/353
CPCA01N33/12A01N47/44A61K31/14A61K31/155A61K31/353A01N2300/00A61K2300/00
Inventor 杜武华林栋青刁盈盈王江
Owner SHANDONG WEIGAO PHARM CO LTD
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