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Application of obakunone to preparation of medicine for preventing and treating lung injury and pulmonary fibrosis

A technology of pulmonary fibrosis, cortex ketone, applied in the active field of anti-lung injury and anti-pulmonary fibrosis

Active Publication Date: 2016-07-20
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the function of phellodendron in the prevention and treatment of lung injury and pulmonary fibrosis has not been reported yet.

Method used

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  • Application of obakunone to preparation of medicine for preventing and treating lung injury and pulmonary fibrosis
  • Application of obakunone to preparation of medicine for preventing and treating lung injury and pulmonary fibrosis
  • Application of obakunone to preparation of medicine for preventing and treating lung injury and pulmonary fibrosis

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0060] Example 1 (injection)

[0061] 1. Prescription:

[0062]

[0063] 2. Preparation method

[0064] Soak phellodendron in soybean oil and oleic acid as the oil phase, stir continuously and heat to 70°C, disperse polyethylene glycol 15-hydroxystearate, soybean lecithin, glycerin, and hexasodium phytate in water as the water phase , continuously stirring and heating to 70°C, slowly adding the oil phase to the water phase, stirring at a high speed with a high-speed disperser for 8 minutes (rotating speed 2000 rpm) to obtain colostrum, and homogenizing the colostrum with a high-pressure homogenizer (pressure 65MPa , temperature 75°C) after 7 times, diluted with water for injection to 1000ml, filtered through a 0.45μm microporous membrane, filled with nitrogen, packed and melted, and autoclaved (121°C, 15min). 1ml per tube, intramuscular injection, once a day, 2 tubes each time, 10 to 20 days as a course of treatment, can be used continuously for 2 to 3 courses of treatmen...

example 2

[0065] Example 2 (tablet)

[0066] 1. Prescription:

[0067]

[0068] 2. Preparation method:

[0069] Dissolve phellodendron and hydroxypropyl cellulose SSL in 800mL of ethanol, add the above solution into liquid paraffin, dry under reduced pressure to remove ethanol, phellodendron and hydroxypropyl cellulose form fine particles to precipitate, and dry the precipitated particles at 50°C The dried microparticles are mixed evenly with croscarmellose sodium and magnesium stearate crossing 100 mesh sieves, and compressed into 10000 tablets each containing phellodendron 30mg, each with a net weight of 0.13g. Oral 2 tablets each time, once a day, 10-20 days as a course of treatment, can be used continuously for 2-3 courses.

example 3

[0070] Example 3 (capsules)

[0071] 1. Prescription:

[0072]

[0073] 2. Preparation method:

[0074] Take by weighing sodium lauryl sulfate and povidone K30 of recipe quantity, add water and dissolve, be mixed with the solution of 10% povidone K30, make adhesive; Add binders to make soft materials, and then use a granulator to granulate; dry the wet granules at 40°C to 45°C for 1 to 3 hours, and then granulate; put the above granules in a mixer, and add low-substituted Hydroxypropyl cellulose, crospovidone and magnesium stearate were mixed for 30 minutes, and samples were taken to determine content and loss on drying; the average loading was calculated according to the results of particle content measurement, and filled with 4# capsules to make 1000 capsules , each capsule is filled with 0.1g granules, containing 20mg of cortex ketone, orally 3 capsules each time, once a day, 10-20 days as a course of treatment, and can be used continuously.

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PUM

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Abstract

The invention relates to application of obakunone to preparation of a medicine for preventing and treating lung injury and pulmonary fibrosis. The medicine consists of obakunone and pharmaceutically acceptable auxiliaries and additives, wherein the obakunone accounts for 3-25% by mass of the medicine. The obakunone in the medicine can inhibit mouse lung injury and pulmonary fibrosis induced by Bleomycin and regulate lymphokine expression related to inflammation of mouse lung injury induced by Bleomycin, and not only is remarkable in effects of preventing and treating lung injury and pulmonary fibrosis, but also has the advantages of low toxicity and no liver or kidney injury.

Description

technical field [0001] The present invention relates to pharmaceutical preparations containing organic active ingredients, in particular to the anti-lung injury and anti-pulmonary fibrosis activities of compounds containing lactone rings. Background technique [0002] Lung injury is a common disease, and acute lung injury seriously affects human health. Acute lung injury (ALI) is the injury of alveolar epithelial cells and capillary endothelial cells caused by various direct and indirect injury factors, resulting in diffuse pulmonary interstitial and alveolar edema, leading to acute hypoxic respiratory insufficiency. Early stage of respiratory distress syndrome (acuterespiratorydistresssyndrome, ARDS). Pulmonary fibrosis (PF), also known as interstitial lung disease, is a type of pulmonary interstitial disease with extremely poor prognosis and seriously affects the quality of life of patients. It is also one of the most serious diseases of the respiratory system. Current r...

Claims

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Application Information

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IPC IPC(8): A61K31/585A61P11/00
CPCA61K9/2054A61K9/4866A61K31/585A61K47/44A61K9/0019A61K9/2013A61K9/4858A61K31/366A61K47/10A61K47/12A61K47/24A61P11/00
Inventor 徐洋徐胜梅陈为民
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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