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Compound sulfamethoxazole dispersible tablet and preparation method thereof

A technology of sulfamethoxazole and compound sulfonamide, applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of rarely used alone, and achieve good dissolution rate and process Simplicity and the effect of reducing production costs

Inactive Publication Date: 2016-07-20
KAMP PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This product is a broad-spectrum antibacterial drug, and its antibacterial spectrum is similar to that of sulfonamides. It has the effect of inhibiting dihydrofolate reductase, but bacteria are prone to drug resistance, so it is rarely used alone

Method used

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  • Compound sulfamethoxazole dispersible tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0024] Prescription (1000 tablets):

[0025] Sulfamethoxazole 400 parts

[0026] Trimethoprim 80 parts

[0027] 200 parts powdered sugar

[0028] Starch 200 parts

[0029] Low-substituted hydroxypropyl cellulose 100 parts

[0030] Colloidal silicon dioxide 16 parts

[0031] 4 parts magnesium stearate

example 2

[0033] Prescription (1000 tablets):

[0034] Ampicillin 400 parts

[0035] Potassium clavulanate 80 parts

[0036] 250 parts powdered sugar

[0037] Microcrystalline cellulose 150 parts

[0038] Low-substituted hydroxypropyl cellulose 95 parts

[0039] 21 parts of colloidal silicon dioxide

[0040] 4 parts magnesium stearate

example 3

[0042] Prescription (4000 tablets):

[0043] Ampicillin 400 parts

[0044] Potassium clavulanate 80 parts

[0045] 150 parts powdered sugar

[0046] 250 parts of starch

[0047] Low-substituted hydroxypropyl cellulose 100 parts

[0048] Colloidal silicon dioxide 17 parts

[0049] 3 parts magnesium stearate

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Abstract

The invention discloses a compound sulfamethoxazole dispersible tablet and a preparation method thereof. The dispersible tablet is characterized in that the compound sulfamethoxazole dispersible tablet prescription comprises the following components in parts by weight: 360-500 parts of sulfamethoxazole, 50-100 parts of trimethoprim, 360-420 parts of a filler, 80-120 parts of a disintegrating agent, and 3-5 parts of a lubricant. The compound sulfamethoxazole dispersible tablet has the advantages of scientific formula, simple process, rapid disintegration of preparation, good dissolution rate, cheap and easily available auxiliary materials, and low cost; the tablet is suitable for large scale production, and can reduce drug usage burden of patients.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a compound sulfamethoxazole dispersible tablet and a preparation method thereof. Background technique [0002] Sulfamethoxazole, also known as Sinomine or SMZ, is a broad-spectrum antibiotic. It has inhibitory effect on most Gram-positive and Gram-negative bacteria. It is mainly used for the prevention of urinary tract infection, respiratory system infection, intestinal infection, biliary tract infection and local soft tissue or wound infection caused by sensitive bacteria, meningococcus-induced meningitis, otitis media caused by influenza bacillus, etc. [0003] Trimethoprim, English / Latin name: Trimethoprim, TMP for short. This product is white or off-white crystalline powder; odorless, bitter taste. This product is slightly soluble in chloroform, slightly soluble in ethanol or acetone, almost insoluble in water; easily soluble in glacial acetic acid. This product...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/635A61K9/20A61K47/38A61P31/04A61K31/505
Inventor 曾培安刘娟吴健民张静
Owner KAMP PHARMA
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