Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Absorbable starch styptic powder, preparation method and applications thereof

A hemostatic powder, absorbable technology, applied in the field of absorbable starch hemostatic powder and its preparation, can solve the problems of limited application, high price, long degradation time, etc., and achieves the reduction of blood flow speed, simple and convenient use, and biocompatibility. good effect

Inactive Publication Date: 2016-07-20
CHONGQING LIANBAI BOCHAO MEDICAL EQUIP
View PDF4 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the clinically used hemostatic materials mainly include fibrin glue, collagen, gelatin sponge and cellulose hemostatic materials. These materials have achieved good results in animal experiments and clinical applications, but there are also some shortcomings: The raw material is derived from animal tissue, which is a foreign protein, which is prone to rejection and has potential sensitization; gelatin absorbs slowly, generally more than 4 weeks, which will increase the risk of wound infection; cellulose, the human body lacks enzymes to degrade it , the degradation time is long, which may bring side effects such as infection to the patient
At present, the representative starch hemostatic material is Arista hemostatic powder produced in the United States. Although its hemostatic effect is good, it is cross-linked with epichlorohydrin, which is potentially toxic and expensive, which limits its application.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 1) Dissolve 0.2g of potato starch and 10g of hydroxymethyl starch in 300ml of distilled water, stir well and adjust the pH to 9-10 with sodium hydroxide to prepare a mixed starch suspension;

[0021] 2) Dissolve 4.5g of Span 80 and Tween 80 in 800ml of vegetable oil and stir at 50±5°C for 20 minutes to prepare a mixed emulsified dispersant, then add it to the mixed starch suspension and stir for 20 minutes to prepare a mixed starch emulsified liquid;

[0022] 3) Weigh 0.2g of sodium trimetaphosphate and dissolve it in distilled water, then add it into the mixed starch emulsion, stir and cross-link for 3 hours to obtain a cross-linking liquid;

[0023] 4) Leave the cross-linking liquid to stand for stratification, discard the supernatant, add 5 times the volume of ethyl acetate to the milky white liquid in the lower layer, stir evenly, let stand for stratification, remove the milky white liquid in the lower layer, add 3 times the volume of absolute ethanol to wash , aft...

Embodiment 2

[0026] 1) Weigh 10g of potato starch, dissolve 10g of hydroxymethyl starch in 600ml of distilled water, stir well and adjust the pH to 9-10 with sodium hydroxide to prepare a mixed starch suspension;

[0027] 2) Dissolve 10g of Span 80 and Tween 80 in 1200ml of vegetable oil, stir at 50±5°C for 20min to prepare a mixed emulsified dispersant, then add it to the mixed starch suspension and stir for 20min to prepare a mixed starch emulsion ;

[0028] 3) Weigh 1.0 g of sodium trimetaphosphate and dissolve it in distilled water, then add it into the mixed starch emulsion, stir and cross-link for 5 hours to obtain a cross-linking liquid;

[0029] 4) Leave the cross-linking liquid to stand for stratification, discard the supernatant, add 5 times the volume of ethyl acetate to the milky white liquid in the lower layer, stir evenly, then let it stand for stratification, remove the milky white liquid in the lower layer, add 3 times the volume of absolute ethanol to wash , after stirrin...

Embodiment 3

[0032] 1) Weigh 5g of potato starch, dissolve 10g of hydroxymethyl starch in 450ml of distilled water, stir well and adjust the pH to 9-10 with sodium hydroxide to prepare a mixed starch suspension;

[0033] 2) Dissolve 6g of Span 80 and Tween 80 in 800ml of vegetable oil, stir at 50±5°C for 20 minutes to prepare a mixed emulsified dispersant, then add it to the mixed starch suspension and stir for 20 minutes to prepare a mixed starch emulsion ;

[0034] 3) Weigh 0.5g of sodium trimetaphosphate and dissolve it in distilled water, then add it into the mixed starch emulsion, stir and cross-link for 3 hours to obtain a cross-linking liquid;

[0035] 4) Leave the cross-linking liquid to stand for stratification, discard the supernatant, add 5 times the volume of ethyl acetate to the milky white liquid in the lower layer, stir evenly, let stand for stratification, remove the milky white liquid in the lower layer, add 3 times the volume of absolute ethanol to wash , after stirring ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an absorbable starch styptic powder, and a preparation method thereof. The absorbable starch styptic powder is prepared by the following steps: taking plant origin starch and hydroxyethyl starch as the raw materials, emulsifying and dispersing the starches in span 80, tween 80, and plant oil at a temperature of 45 to 70 DEG C under a pH value of 9 to 10, adding sodium trimetaphosphate to carry out crosslinking, using ethyl acetate to perform extraction and liquid separation, washing the solid by anhydrous ethanol, drying the solid in a baking oven, and performing sterilization to obtain the styptic powder. The styptic powder has a good biocompatibility, can be directly applied to the common bleeding parts, deep bleeding parts, and bleeding parts that are hard to reach through surgery operation, and is simple and convenient to use. Starches are the raw materials of the styptic powder, thus the styptic powder is nontoxic and nonirritant, moreover, the sources of raw materials are wide, the cost is low, the technology is simple and feasible, and thus the styptic powder has a wide clinical application prospect.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to an absorbable starch hemostatic powder and a preparation method and application thereof. Background technique [0002] War wounds, trauma first aid and surgical operations will all cause bleeding. This problem needs to be solved urgently. The normal human body has the function of hemostasis. Slow and small amount of bleeding can stop bleeding by relying on its own function. The body cannot stop the bleeding by itself, nor can it only rely on ordinary hemostatic bandages to stop the bleeding. If the patient loses too much blood, it may cause shock and even endanger life and health. Currently, the commonly used effective hemostasis method is to use biocompatible absorbable materials to stop bleeding. It is particularly important to provide a safe, effective, easy-to-use, and low-cost hemostatic material in hemostasis such as surgery and first aid. [0003] At presen...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/44C08B31/00
Inventor 张大刘琼
Owner CHONGQING LIANBAI BOCHAO MEDICAL EQUIP
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products