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General flavone with effect of treating diabetic mellitus, as well as preparation method and application thereof

A technology of total flavonoids and diabetes, which is applied in the field of total flavonoids of Sophora sophora, can solve the problems of high impurities, low extraction amount of total flavonoids, and affecting the comprehensive utilization of total flavonoids of sophora sophora, achieve high purity, good effect on treating diabetes, and less impurities Effect

Inactive Publication Date: 2016-08-10
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The total flavonoids extracted by these methods are low and there are many impurities, which affect the comprehensive utilization of the total flavonoids of Sophora sophora

Method used

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  • General flavone with effect of treating diabetic mellitus, as well as preparation method and application thereof
  • General flavone with effect of treating diabetic mellitus, as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0037] Experimental Example 1 Enrichment of Sophora Sophora Total Flavonoids from Rhizome of Sophora Sophora

[0038] 1. Experimental materials

[0039] The experimental material is Sophora alopecuroides.L, a plant of the leguminous family Sophora

[0040] 2. Experimental instruments and equipment

[0041] Pulverizer, electric heating mantle, rotary evaporator, low-speed large-capacity multi-tube centrifuge, ultrasonic instrument, vacuum drying oven, polyamide, DM-130 macroporous resin

[0042] 3. Extraction and enrichment

[0043] (1) further dry the collected medicinal materials of Sophora sophora, weigh them, and crush them through 20 meshes. The crushed medicinal materials are refluxed with 8 times the amount of 70% ethanol and extracted 3 times, each time for two hours, and the extracts are filtered and combined , concentrated under reduced pressure at 65°C to no alcohol smell;

[0044] (2) Put the concentrate of step (1) on a polyamide column for separation and purif...

experiment example 2

[0047] Experimental example 2 Therapeutic effect of the mixture of total flavonoids of Sophora japonica on type 2 diabetes and type 2 diabetic liver disease

[0048] 1. Animals: 40 pure-line clean Wistar rats, 180-220g.

[0049] 2. Grouping: After pre-feeding for 1 week, all rats were randomly divided into two groups: 8 rats in the normal group (K group) were given a normal diet; the remaining 32 rats were given a high-fat and high-sugar diet plus tail vein injection of streptozotocin (STZ ) for modeling, and after 8 weeks, the fasting blood glucose (FBG) was measured, and the model was established successfully if FBG≥16.8mmol / L. The 24 rats that successfully modeled were divided into four groups at random: model group (M group), metformin group (Y group, 150mg / kg, as positive drug control), the high-concentration Sophora Sophorae total flavonoids prepared in Example 1 Group (G1 group) and the low-concentration total flavonoids group of Sophora flavonoids prepared in Example ...

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Abstract

The invention discloses a general flavone with an effect of treating diabetic mellitus, as well as a preparation method and application thereof. According to the preparation method, sophora alopecuroide is used as a raw material, an optimal separation purification process is screened by massive experiments, combination of a polyamide column chromatography and a macroporous resin column are especially utilized, a preferable elution solution is adopted for eluting, the refined general flavone prepared by separation has high purity and small impurity content, and the general flavone of sophora alopecuroide prepared by separation has high activity. Experiment results indicate that the refined general flavone provided by the invention has a good effect for treating diabetic mellitus, has a good treatment effect on diabetic mellitus, diabetic hepatopathy and other related diseases, does not have side effects or other adverse response in the experiment process, and is expected to be developed into a safe and effective medicine for preventing and treating diabetic mellitus.

Description

technical field [0001] The invention relates to total flavonoids from Sophora sophora, in particular to the flavonoids enriched from Sophora sophora and its new pharmacological application in treating type 2 diabetes and type 2 diabetic liver disease. Background technique: [0002] Diabetes is one of the most common epidemic diseases in the world, and its mortality rate is second only to vascular diseases and malignant tumors in developed countries, becoming the third leading cause of death. It is a chronic systemic disease related to genetic factors and various environmental factors. It is a syndrome of carbohydrate and fat metabolism disorders in the body caused by insufficient insulin secretion or utilization. Diabetic liver disease has become a diabetic disease. In addition to kidney, heart, retina, and neuropathy, chronic complications are another chronic complication that has attracted people's attention. The number of diabetic patients in my country has shown a very ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/489A61P3/10A61P1/16
CPCA61K36/489A61K2236/33A61K2236/51A61K2236/53A61K2236/55
Inventor 王汉卿陶伟伟张立明陈丽高晓娟张霞赵建军余建强王英华
Owner NINGXIA MEDICAL UNIV