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Surface molecularly imprinted polymer used for selectively absorbing sulfamonomethoxine and preparation method thereof and application thereof

A sulfamethoxine, surface molecular imprinting technology, applied in chemical instruments and methods, other chemical processes, etc., can solve the problems of reduced target recognition ability, interference, etc., and achieves easy regeneration and recycling, fast mass transfer, The effect of uniform particle size

Active Publication Date: 2016-08-10
HENAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, most molecularly imprinted polymers are prepared in non-polar or weakly polar organic solvents (such as acetonitrile, chloroform, toluene, etc.), and the corresponding weakly polar organic solvents have higher Imprinting efficiency, while in strong polar media, the ability to recognize the target is significantly reduced due to the interference of polar solvent molecules

Method used

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  • Surface molecularly imprinted polymer used for selectively absorbing sulfamonomethoxine and preparation method thereof and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] With 50mL of methanol as the solvent, 0.4g of vinylated silica gel as the carrier, sulfamethoxine as the template molecule (0.14g), and 1-allyl-3-vinylimidazole chloride as the functional monomer, then add Cross-linking agent ethylene glycol dimethacrylate and initiator azobisisobutyronitrile, the molar ratio of template molecule, functional monomer, cross-linking agent and initiator is 1:2:20:0.06, heated at 60°C Initiate the polymerization for 24 hours, and perform Soxhlet extraction with a mixed solution of methanol / acetic acid (V / V=9 / 1) to obtain a molecularly imprinted polymer adsorbent for sulfamethoxine. This polymer has obvious specific adsorption for sulfamethoxine performance.

Embodiment 2

[0021] With 50mL of methanol as the solvent, 0.4g of vinylated silica gel as the carrier, sulfamethoxine as the template molecule (0.14g), and 1-allyl-3-vinylimidazole chloride as the functional monomer, then add Cross-linking agent ethylene glycol dimethacrylate and initiator azobisisobutyronitrile, the molar ratio of template molecule, functional monomer, cross-linking agent and initiator is 1:6:20:0.06, heated at 60°C Initiate the polymerization for 24 hours, and perform Soxhlet extraction with a mixed solution of methanol / acetic acid (V / V=9 / 1) to obtain a molecularly imprinted polymer adsorbent for sulfamethoxine. This polymer has obvious specific adsorption for sulfamethoxine performance.

Embodiment 3

[0023] With 50mL of methanol as the solvent, 0.4g of vinylated silica gel as the carrier, sulfamethoxine as the template molecule (0.14g), and 1-allyl-3-vinylimidazole chloride as the functional monomer, then add Cross-linking agent ethylene glycol dimethacrylate and initiator azobisisobutyronitrile, the molar ratio of template molecule, functional monomer, cross-linking agent and initiator is 1:8:15:0.03, heated at 60°C Initiate the polymerization for 24 hours, and perform Soxhlet extraction with a mixed solution of methanol / acetic acid (V / V=9 / 1) to obtain a molecularly imprinted polymer adsorbent for sulfamethoxine. This polymer has obvious specific adsorption for sulfamethoxine performance.

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Abstract

The invention discloses a surface molecularly imprinted polymer used for selectively absorbing sulfamonomethoxine and a preparation method thereof and application thereof. The surface molecularly imprinted polymer used for selectively absorbing sulfamonomethoxine uses methanol as a solvent, vinyl silicone as a carrier, sulfamonomethoxine as template molecule, chloride1-allyl-3-vinyl imidazole ionic liquid as functional monomer, ethylene glycol dimethacrylate as a cross-linking agent, and azodiisobutyronitrile as an initiator, and the sulfamonomethoxine molecularly imprinted polymer adsorbent is prepared by chain initiation polymerization. The invention also discloses the preparation method of the surface molecularly imprinted polymer, and the application thereof in the pretreatment of the selective separation and enrichment of trace sulfamonomethoxine in the environment. The surface molecularly imprinted polymer adsorbent prepared by the invention has uniform particle size, strong preferential adsorption property, high adsorption capacity, and good mechanical property, and is easy to recycle.

Description

technical field [0001] The invention belongs to the technical field of molecularly imprinted polymer adsorbents for trace amounts of sulfonamide antibiotics in environmental samples, and in particular relates to a surface molecularly imprinted polymer for selectively adsorbing sulfamethoxine, a preparation method and application thereof. Background technique [0002] Sulfa drugs are a class of antibiotics widely used in human and veterinary medicines. After ingested by humans and animals, only a small part of the drugs are absorbed, and most of them exist in the environment in the form of original drugs or intermediate metabolites. With continuous input, bacteria will develop drug resistance and may bind to non-target receptors, thereby producing various unpredictable physiological effects and seriously threatening human health. Therefore, rapid and accurate analysis and detection of sulfonamide antibiotic residues is of great significance to environmental protection and hum...

Claims

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Application Information

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IPC IPC(8): C08F222/14C08F226/06C08J9/26B01J20/26B01J20/30
CPCB01J20/268C08F222/1006C08J9/26C08J2201/0424C08J2335/02C08F222/102C08F226/06
Inventor 朱桂芬于文娜苏现伐王莉茹祥莉王培云程国浩赵轩樊静
Owner HENAN NORMAL UNIV
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