A method for surface modification of biodegradable iron and iron alloys by zinc ion implantation

A technology of biodegradation and ion implantation, applied in ion implantation plating, drug delivery, tissue regeneration, etc., can solve the problems of unreported, allergic and inflammatory reactions, insufficient binding force between the zinc film and the substrate, etc., to improve biological Compatibility, effect of increasing corrosion rate

Active Publication Date: 2019-02-15
BEIHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This will cause some problems in actual use: First, certain toxic ions (such as Cr ions in stainless steel, Ni ions in NiTi alloys, etc.) that are dissolved out of the metal surface after corrosion and wear may cause allergic and inflammatory reactions in the body; Secondly, long-term indwelling of vascular stents may cause endothelial tissue hyperplasia and restenosis; finally, temporary implanted devices (such as bone nails, bone plates, etc.) need to be removed after tissue repair, which increases the patient's pain and economic burden
However, it is difficult to prepare zinc and iron into alloys through conventional smelting processes. If a zinc film with good bonding force and moderate thickness can be prepared on the surface of iron and iron alloys, the problem of slow degradation rate of iron alloys can be solved, while ensuring that the materials have good biocompatibility and full degradability
The patent application with the application number 201610036887.9 discloses a "galvanized iron alloy", which uses electrolysis to prepare a layer of galvanized film on the surface of the iron alloy to improve the softness and color of the iron alloy, but the zinc prepared by electrolysis The bonding force between the film layer and the substrate is insufficient, and it is easy to peel off under the action of corrosion or external force
At present, there is no report on the use of zinc thin films to improve the corrosion rate of iron and iron alloys

Method used

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  • A method for surface modification of biodegradable iron and iron alloys by zinc ion implantation
  • A method for surface modification of biodegradable iron and iron alloys by zinc ion implantation
  • A method for surface modification of biodegradable iron and iron alloys by zinc ion implantation

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Embodiment 1

[0035] The first step: substrate pretreatment:

[0036] After the biomedical pure iron substrate is ground and polished, it is ultrasonically cleaned with acetone and absolute ethanol for 15 minutes to prepare the substrate sample;

[0037] The second step: ion implantation to prepare zinc surface modification layer:

[0038] (A) Put the substrate sample prepared in the first step into an ion implanter to remove surface impurities by argon ion sputtering; wherein, the vacuum degree is 0.2×10 -3 Pa, energy 8k V, time 5min;

[0039] (B) The substrate sample treated with argon ions is doped with zinc element to obtain a sample with a zinc surface modification layer; the ion implanter selects the target material as a zinc target, and the parameters required for doping zinc element: vacuum Degree 2.0×10 -3 Pa, zinc dose 1×10 17 ions / cm 2 , voltage energy 40k V, current 1.5mA;

[0040] The third step: heat treatment of the film:

[0041] Put the sample with the zinc surface m...

Embodiment 2

[0051] The first step: substrate pretreatment:

[0052] After the biomedical iron alloy Fe-X (X = any one of Mn, Co, W, Si) alloy matrix is ​​ground and polished, it is ultrasonically cleaned with acetone and absolute ethanol for 15 minutes to prepare the matrix sample;

[0053] The second step: ion implantation to prepare zinc surface modification layer:

[0054] (A) Put the substrate sample prepared in the first step into an ion implanter to remove surface impurities by argon ion sputtering; wherein, the degree of vacuum is 0.1×10 -3 Pa, energy 12k V, time 10min;

[0055] (B) The substrate sample treated with argon ions is doped with zinc element to obtain a sample with a zinc surface modification layer; the ion implanter selects the target material as a zinc target, and the parameters required for doping zinc element: vacuum Degree 2.0×10 -3 Pa, zinc dose 2×10 17 ions / cm 2 , voltage energy 40k V, current 2mA;

[0056] The third step: heat treatment of the film:

[00...

Embodiment 3

[0060] The first step: substrate pretreatment:

[0061] After the biomedical iron alloy Fe-Mn-Si alloy substrate was ground and polished, it was ultrasonically cleaned with acetone and absolute ethanol for 15 minutes to obtain a substrate sample;

[0062] The second step: ion implantation to prepare zinc surface modification layer:

[0063] (A) Put the substrate sample prepared in the first step into an ion implanter to remove surface impurities by argon ion sputtering; wherein, the degree of vacuum is 0.25×10 -3 Pa, energy 12k V, time 10min;

[0064] (B) The substrate sample treated with argon ions is doped with zinc element to obtain a sample with a zinc surface modification layer; the ion implanter selects the target material as a zinc target, and the parameters required for doping zinc element: vacuum Degree 2.0×10 -3 Pa, zinc dose 3×10 17 ions / cm 2 , voltage energy 60k V, current 1mA;

[0065] The third step: heat treatment of the film:

[0066] Put the sample with...

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Abstract

The invention discloses a method for surface modification of biodegradable iron and iron alloy by zinc ion implantation, which belongs to the technical field of surface treatment. In the present invention, a modified layer doped with zinc is formed on the surface of iron and iron alloy by zinc ion implantation. In the surface modified layer, a mixture phase of iron-zinc second phase, iron oxide and zinc oxide is formed, with a thickness of 50 ~100nm, the implanted element zinc shows a Gaussian distribution. The zinc surface modification layer prepared by the invention has good bonding strength with the substrate, improves the corrosion rate of iron and iron alloy, and has good biocompatibility at the same time.

Description

technical field [0001] The invention belongs to a surface treatment technology of biodegradable iron and iron alloy Fe-X (X = one or more than two kinds of biocompatible elements such as Mn, Co, W, Si, etc.). The zinc element is injected into the surface of the iron alloy to a certain depth, and then the surface modified sample is heat treated to finally prepare the iron and iron alloy with the zinc surface modified layer. Background technique [0002] Biomedical metal materials are widely used in the fields of orthopedics, cardiovascular and plastic surgery due to their excellent mechanical properties. Metal materials currently used clinically, including medical stainless steel, titanium and titanium alloys, NiTi shape memory alloys, cobalt-chromium alloys, etc., are biologically inert and can exist in the body for a long time. This will cause some problems in actual use: First, certain toxic ions (such as Cr ions in stainless steel, Ni ions in NiTi alloys, etc.) that are ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C23C14/48C23C14/16A61L27/04A61L27/50A61L31/02A61L31/14
CPCA61L27/042A61L27/50A61L31/022A61L31/14A61L2400/18A61L2430/02C23C14/16C23C14/48
Inventor 汪赫男郑洋李岩
Owner BEIHANG UNIV
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