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Fullerene micro-nano material with effects of prevention and/or treatment on myelosuppression and use thereof

A fullerene micro-nano, bone marrow suppression technology, applied in the field of biomedicine, can solve problems such as easy to cause gastrointestinal reactions, not widely used, low absorption rate, etc., achieve excellent bone marrow suppression, efficiently scavenge free radicals, prevent and treat bone marrow inhibitory effect

Active Publication Date: 2016-08-31
BEIJING FUNAKANG BIOTECH CO LTD
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

In the prevention and treatment of bone marrow hematopoietic suppression, although many Chinese and Western medicines have certain curative effects, their application is limited due to their low absorption rate in the human gastrointestinal tract and easy to cause gastrointestinal reactions; An effective treatment method is the use of hematopoietic growth factors (HGFs), but due to the high price and its own defects, it is not widely used at present

Method used

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  • Fullerene micro-nano material with effects of prevention and/or treatment on myelosuppression and use thereof
  • Fullerene micro-nano material with effects of prevention and/or treatment on myelosuppression and use thereof
  • Fullerene micro-nano material with effects of prevention and/or treatment on myelosuppression and use thereof

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Experimental program
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Effect test

Embodiment 1

[0039] Embodiment 1, water-soluble gadolinium hydroxylated metal fullerene (GFNC) scavenging free radical effect in vitro

[0040] 1) Electron paramagnetic resonance (ESR) detection of free radical intensity experiment:

[0041] The method of producing hydroxyl radicals induced by ultraviolet rays was used. The control group was: 50 μL of hydrogen peroxide with a mass concentration of 37%, 50 μL of PBS buffer (pH=7.4) and a small amount (0.133 mM) of lutidine N-oxide (DMPO, Free radical scavenger) solutions were mixed, irradiated with 280nm ultraviolet light for 8min, and the signal of hydroxyl radicals could be produced at this time; the experimental group was: 50 μL of hydrogen peroxide with a mass concentration of 37%, 50 μL of PBS buffer (pH=7.4) and A small amount (0.133mM) of lutidine N-oxide (DMPO, free radical scavenger) solution was mixed, and 10μL of 20μM water-soluble gadolinium hydroxylated metal fullerene aqueous solution was immediately added, and 280nm ultraviol...

Embodiment 2

[0043] Embodiment 2, the free radical scavenging effect of water-soluble hydroxylated hollow fullerene in vitro

[0044] 1) Electron paramagnetic resonance (ESR) detection of free radical intensity experiment:

[0045] The method of producing hydroxyl radicals induced by ultraviolet rays was used. The control group was: 50 μL of hydrogen peroxide with a mass concentration of 37%, 50 μL of PBS buffer (pH=7.4) and a small amount (0.133 mM) of lutidine N-oxide (DMPO, Free radical scavenger) solutions were mixed, irradiated with 280nm ultraviolet light for 8min, and the signal of hydroxyl radicals could be produced at this time; the experimental group was: 50 μL of hydrogen peroxide with a mass concentration of 37%, 50 μL of PBS buffer (pH=7.4) and A small amount (0.133mM) of lutidine N-oxide (DMPO, free radical scavenger) solution was mixed, and 10 μL of 20 μM water-soluble hydroxylated hollow fullerene aqueous solution was immediately added, and 280nm ultraviolet light was irrad...

Embodiment 3

[0047] Example 3. Myelosuppressive Protection of Water-Soluble Gadolinium Hydroxylated Metallofullerenes in Vivo Levels

[0048] Animal model: 4-5 week old ICR mice were selected and randomly divided into 4 groups, 6 mice in each group, corresponding to blank control group, GFNC experimental group, X-ray irradiation experimental group and X-ray + GFNC experimental group respectively. Inoculate 10 on the right thigh of mice 6 A mouse hepatoma cell (H22 cell) was inoculated 5-7 days later, when the tumor diameter reached about 5 mm, the experiment was carried out.

[0049] Blank control group: the drugs injected in the experimental group were replaced by the same volume of normal saline, and the same volume of normal saline was injected intravenously.

[0050] GFNC experimental group: mice were injected with GFNC aqueous solution (1 mM) through the tail vein, and the drug dosage was 0.004 mmol GFNC / kg mouse body weight.

[0051] X-ray irradiation experiment group: the whole bo...

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Abstract

The invention discloses a fullerene micro-nano material with effects of prevention and / or treatment on myelosuppression and a use thereof. The novel use of the fullerene micro-nano material comprises use of the fullerene and / or metallofullerene micro-nano material in a drug or a drug carrier with at least one of properties such as 1, prevention and / or treatment on myelosuppression, 2, prevention and / or treatment on at least one of myelosuppression-caused leucopenia, platelet decreasing, hemoglobin decreasing and monocyte decreasing, and 3, protection of liver tissue, spleen tissue and kidney tissue. The myelosuppression is caused through tumor radiation therapy or rays producing myelosuppression side effects. The fullerene and / or metallofullerene micro-nano material can prevent and treat myelosuppression and prevent liver, spleen and kidney damage.

Description

technical field [0001] The invention relates to a fullerene micro-nano material for preventing and / or treating myelosuppression and an application thereof, belonging to the field of biomedicine. Background technique [0002] In recent years, the incidence of malignant tumors has been increasing, seriously endangering people's health. Although a variety of cancer treatment methods have emerged in recent years, radiotherapy is still one of the commonly used clinical treatments for malignant tumors. As we all know, while most radiotherapy methods kill cancer cells, they also damage normal cells in the human body, which has relatively large side effects, especially the killing effect on bone marrow cells may cause secondary damage to patients and even suffer from diseases such as leukemia. Seriously affect the quality of life of patients and its clinical application. At present, 60%-70% of cancer patients need radiotherapy and chemotherapy. Generally, reasonable radiotherapy a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/10A61K47/04A61P7/06A61P7/00A61P1/16A61P1/14A61P13/12
CPCA61K47/02A61K47/10
Inventor 王春儒甄明明张莹
Owner BEIJING FUNAKANG BIOTECH CO LTD
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