Bone tissue repair material based on shape memory composite material as well as preparation method and application method of bone tissue repair structure

A technology for repairing structures and composite materials, applied in tissue regeneration, additive manufacturing, pharmaceutical formulations, etc., can solve problems such as the satisfaction of doctors and patients that affect the use of hard tissue repair materials, the inability to fuse surrounding tissues, and the unsatisfactory degradation performance. To achieve the effect of strong controllability of repaired shape, tight growth of bone cells and easy shaping

Inactive Publication Date: 2016-09-21
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, with the continuous deepening of research and wide clinical application, it is found that the biomaterials currently used in clinical practice have insufficient biological activity, or unsatisfactory degradation performance, and the materials exis...

Method used

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  • Bone tissue repair material based on shape memory composite material as well as preparation method and application method of bone tissue repair structure

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A method for preparing a bone tissue repair structure based on a shape memory composite material, comprising the following steps,

[0019] (1) Diagnose the size and shape of the bone injury site and obtain a three-dimensional graphic;

[0020] (2) according to the three-dimensional figure, the predetermined shape of the shape memory composite material during three-dimensional printing is constructed by computer;

[0021] (3) the weight component is 90 parts of shape memory polycaprolactone, 1 part of reinforcing material and 1 part of Fe 3 o 4 The nanoparticles are uniformly mixed by ultrasonic dispersion method to obtain a viscous liquid, which is solidified and cut into block solids, wherein the reinforcing material is starch or cellulose;

[0022] (4) The block solid is made into a filament by pultrusion, and then integrated by three-dimensional printing technology, and then cross-linked by ultraviolet light to obtain a bone tissue repair structure based on a shape...

Embodiment 2

[0027] The preparation method of the bone tissue repair structure based on the shape memory composite material as described above comprises the following steps,

[0028] (1) Diagnose the size and shape of the bone injury site and obtain a three-dimensional graphic;

[0029] (2) according to the three-dimensional figure, the predetermined shape of the shape memory composite material during three-dimensional printing is constructed by computer;

[0030] (3) the weight component is 92 parts of shape-memory polylactic acid, 3 parts of reinforcing material and 3 parts of Fe 3 o 4 The nanoparticles are uniformly mixed by ultrasonic dispersion to obtain a viscous liquid, which is solidified and cut into massive solids, wherein the reinforcing material is chitin;

[0031] (4) The block solid is made into a filament by pultrusion, and then integrated by three-dimensional printing technology, and then cross-linked by ultraviolet light to obtain a bone tissue repair structure based on ...

Embodiment 3

[0033] The preparation method of the bone tissue repair structure based on the shape memory composite material as described above comprises the following steps,

[0034] (1) Diagnose the size and shape of the bone injury site and obtain a three-dimensional graphic;

[0035] (2) according to the three-dimensional figure, the predetermined shape of the shape memory composite material during three-dimensional printing is constructed by computer;

[0036] (3) the weight component is 94 parts of shape-memory polyurethane, 2 parts of reinforcing material and 5 parts of gamma-Fe 2 o 3 Nanoparticles are uniformly mixed by ultrasonic dispersion to obtain a viscous liquid, solidified, and cut into block solids, wherein the reinforcing material is lignin or hyaluronic acid or alginic acid;

[0037] (4) The block solid is made into a filament by pultrusion, and then integrated by three-dimensional printing technology, and then cross-linked by ultraviolet light to obtain a bone tissue re...

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Abstract

The invention provides a bone tissue repair structure based on a shape memory composite material as well as a preparation method and an application method of the bone tissue repair structure. The preparation method comprises the following steps: (1) diagnosing the size and the shape of a bone injury part, so that a three-dimensional figure is obtained; (2) in accordance with the three-dimensional figure, constructing a preset shape of the shape memory composite material during printing by virtue of a computer; (3) uniformly mixing the following components in parts by weight by virtue of an ultrasonic dispersion method: 90-99 parts of a shape memory polymer, 1-5 parts of a reinforcing material and 1-10 parts of magnetic nanoparticles, so as to obtain a thick liquid, curing and cutting the cured liquid so as to obtain a solid in the form of a block; and (4) sequentially conducting extrusion-molding, three-dimensional printing and ultraviolet irradiation cross-linking on the block-shaped solid, so that the bone tissue repair structure of the shape memory composite material in the preset shape is obtained. The bone tissue repair structure disclosed by the invention has the beneficial effects that bone tissue cells can be induced to grow along the recovery direction of the bone tissue repair structure when the bone tissue repair structure is driven by an external magnetic field, so that repair of bone defect is achieved and the bone cells can grow more tightly.

Description

technical field [0001] The invention relates to a bone tissue repair structure, in particular to a bone tissue repair structure based on a shape memory composite material and a preparation and application method thereof. Background technique [0002] At present, there are two types of cell scaffold materials used in bone tissue engineering, one is synthetic cell scaffold materials, and the other is natural cell scaffold materials. Iyodo et al. transplanted isolated and cultured rabbit iliac bone osteoblasts and hydroxyapatite to a 6 mm defect of autologous ulna. X-ray and histological examination confirmed that the defect had been completely repaired after 13 weeks. Good biocompatibility, but it is difficult to shape and brittle, and its application is greatly limited; Breitbart et al. made a polyglycolic acid non-woven fiber scaffold into a full-thickness bone defect with a diameter of 15 mm, and there were a large number of defects in the defect area after 12 weeks. Osteo...

Claims

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Application Information

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IPC IPC(8): A61L27/50A61L27/58A61L27/18A61L27/20A61L27/04A61F2/28
CPCA61L27/50A61F2/28A61F2002/2835A61F2002/30985A61F2310/00005A61L27/047A61L27/18A61L27/20A61L27/58A61L2400/16A61L2430/02A61L2430/40C08L67/04C08L75/04C08L3/02C08L1/02C08L5/08C08L97/005C08L5/04
Inventor 刘彦菊冷劲松赵伟周天阳刘立武兰鑫孙健
Owner HARBIN INST OF TECH
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