Tilmicosin granule and preparation method thereof

Abstract

The invention provides a tilmicosin particle, mainly composed of a main material and a phosphoric acid solution with a pH value of 1.0 to 2.0, wherein the main material is prepared from the following materials in terms of mass percent: 5 percent to 30 percent of tilmicosin, 5 percent to 10 percent of polyacrylic resin IV, 0.5 percent to 3 percent of saccharin, 0.5 percent to 2 percent of gourmet powder and 64 percent to 80 percent of starch. The invention further provides a preparation method of the tilmicosin particle. The preparation method comprises the following steps of preparing a mixture, coating the mixture and drying the mixture. The tilmicosin particle provided by the invention has the advantages of simple composition, easiness in storage, good stability, convenience in medication, good palatability, simplicity in preparation step and suitability for industrialized production.

Description

technical field [0001] The invention relates to a veterinary antibacterial drug, in particular to a tilmicosin granule and a preparation method thereof. Background technique [0002] Tilmicosin (C 46 H 80 N 2 O 13 ) is a white to pale yellow crystalline powder, dissolved in water or methanol. Tilmicosin is a semi-synthetic macrolide antibiotic for livestock and poultry, which has inhibitory effects on all Gram-positive bacteria and some Gram-negative bacteria, mycoplasma, spirochetes, etc., especially on pleuropneumoniae. Lineobacillus, Pasteurella hemolytica, Pasteurella multocida and Mycoplasma of livestock and poultry have stronger antibacterial activity than "Tylosin". It is mainly used to prevent and treat livestock pneumonia, avian mycoplasma disease and mastitis in lactating animals caused by Actinobacillus pleuropneumoniae, Pasteurella, Mycoplasma and other infections. It has definite curative effect, remarkable effect and safe use in treating livestock and pou...

AI Technical Summary

Problems solved by technology

[0003] Although tilmicosin has the above advantages, tilmicosin itself has certain irritation and can cause allergic reactions. In severe cases, it has great toxicity to the heart. Negative heart force, leading to animal death, so tilmicosin is mainly administered orally or subcutaneously

When administered orally, because tilmicosin tastes extremely bitter and has an odor, the palatability is poor; on the other hand, micosin is unstable in the stomach, easily degraded and irritating to the gastric mucosa It will cause adverse symptoms such as anorexia, nausea, and vomiting in livestock and poultry, and even some animals will refuse to eat when they smell the smell of tilmicosin, resulting in the failure of drug administration.